Reactome | Interaction of IQGAP1 with nephrin

Interaction of IQGAP1 with nephrin

Stable Identifier

R-HSA-451377

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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IQGAP1, an effector protein of the small GTPases Rac1 and Cdc42 and a putative regulator of cell-cell adherens junctions, is expressed in podocytes at significant levels, and located in the immediate vicinity of the slit diaphragm. IQGAP1 is identified as one of the interacting partners of nephrin. This interaction takes place strictly and specifically between the C-terminal half of the nephrin intracellular domain and IQGAP1. IQGAP1 knock-out mouse does not have any obvious nephrotic phenotype, hence IQGAP1 function can either be substituted by other proteins or its role in vivo is much less important than that attributed to it from cell culture experiments.

Literature References

PubMed ID	Title	Journal	Year
15634346	Characterization of the interactions of the nephrin intracellular domain Liu, XL, Kilpelainen, P, Hellman, U, Sun, Y, Wartiovaara, J, Morgunova, E, Pikkarainen, T, Yan, K, Jonsson, AP, Tryggvason, K	FEBS J	2005
15331416	Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin Lehtonen, S, Lehtonen, E, Kudlicka, K, Holthofer, H, Farquhar, MG	Am J Pathol	2004
10611248	Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1 Li, S, Wang, Q, Chakladar, A, Bronson, RT, Bernards, A	Mol Cell Biol	2000
15994232	Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex Lehtonen, S, Ryan, JJ, Kudlicka, K, Iino, N, Zhou, H, Farquhar, MG	Proc Natl Acad Sci U S A	2005