Interaction of IQGAP1 with nephrin

Stable Identifier
R-HSA-451377
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

IQGAP1, an effector protein of the small GTPases Rac1 and Cdc42 and a putative regulator of cell-cell adherens junctions, is expressed in podocytes at significant levels, and located in the immediate vicinity of the slit diaphragm. IQGAP1 is identified as one of the interacting partners of nephrin. This interaction takes place strictly and specifically between the C-terminal half of the nephrin intracellular domain and IQGAP1. IQGAP1 knock-out mouse does not have any obvious nephrotic phenotype, hence IQGAP1 function can either be substituted by other proteins or its role in vivo is much less important than that attributed to it from cell culture experiments.

Participants
Participant Of
Orthologous Events