Interaction of IQGAP1 with nephrin

Stable Identifier
R-HSA-451377
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IQGAP1, an effector protein of the small GTPases Rac1 and Cdc42 and a putative regulator of cell-cell adherens junctions, is expressed in podocytes at significant levels, and located in the immediate vicinity of the slit diaphragm. IQGAP1 is identified as one of the interacting partners of nephrin. This interaction takes place strictly and specifically between the C-terminal half of the nephrin intracellular domain and IQGAP1. IQGAP1 knock-out mouse does not have any obvious nephrotic phenotype, hence IQGAP1 function can either be substituted by other proteins or its role in vivo is much less important than that attributed to it from cell culture experiments.

Literature References
PubMed ID Title Journal Year
15331416 Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin

Lehtonen, S, Lehtonen, E, Kudlicka, K, Holthofer, H, Farquhar, MG

Am J Pathol 2004
15634346 Characterization of the interactions of the nephrin intracellular domain

Liu, XL, Kilpelainen, P, Hellman, U, Sun, Y, Wartiovaara, J, Morgunova, E, Pikkarainen, T, Yan, K, Jonsson, AP, Tryggvason, K

FEBS J 2005
10611248 Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1

Li, S, Wang, Q, Chakladar, A, Bronson, RT, Bernards, A

Mol Cell Biol 2000
15994232 Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex

Lehtonen, S, Ryan, JJ, Kudlicka, K, Iino, N, Zhou, H, Farquhar, MG

Proc Natl Acad Sci U S A 2005
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