Reactome | TIFA [cytosol]

TIFA [cytosol]

Stable Identifier

R-HSA-451582

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TRAF-interacting protein with FHA domain-containing protein A, TIFA_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96CG3 TIFA

Gene Names

TIFA, T2BP

Chain

chain:1-184

Reference Genes

BioGPS Gene:92610 TIFA

COSMIC (genes):TIFA TIFA

CTD Gene:92610 TIFA

dbSNP Gene:92610 TIFA

ENSEMBL:ENSG00000145365 TIFA

HGNC:19075 TIFA

KEGG:hsa:92610 TIFA

Monarch:92610 TIFA

NCBI Gene:92610 TIFA

OMIM:609028 TIFA

UCSC:Q96CG3 TIFA

Reference Transcript

RefSeq:NM_052864.2 TIFA

Other Identifiers

11720681_at

11720682_at

16979050

226117_PM_at

226117_at

235971_PM_at

235971_at

238858_PM_at

238858_at

2782222

2782224

2782226

2782228

2782229

2782231

2782232

2782233

2782234

2782235

2782236

2782237

2782239

2782240

2782241

64119_at

70543_at

76951_at

8102362

92610

A_23_P352619

A_24_P350686

GE517341

GE767989

GO:0002376

GO:0002753

GO:0005515

GO:0005737

GO:0005829

GO:0033209

GO:0043123

GO:0045087

GO:0051260

GO:0065003

GO:0098542

HMNXSV003033964

Hs.126490.0.A1_3p_at

Hs.310640.0.A1_3p_at

Hs.3985.0.A1_3p_at

ILMN_1686454

PH_hs_0020480

PH_hs_0029723

TC04001476.hg

Participates

as a component of

TIFA:TIFA [cytosol] (Homo sapiens)

Other forms of this molecule

p-T9-TIFA [cytosol]

Inferred To

tifa [cytosol] (Xenopus tropicalis)

Tifa [cytosol] (Mus musculus)

Tifa [cytosol] (Rattus norvegicus)

TIFA [cytosol] (Bos taurus)

TIFA [cytosol] (Canis familiaris)

TIFA [cytosol] (Gallus gallus)

TIFA [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_443096.1

ENSEMBL

ENST00000361717, ENSP00000424231, ENSP00000516322, ENST00000500655, ENST00000610220, ENSP00000354911

OpenTargets

ENSG00000145365

HPA

ENSG00000145365-TIFA

PRO

Q96CG3

Pharos - Targets

Q96CG3

PDB

6A33, 5ZUJ, 4YM4, 4ZGI

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.844	13
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.795	8
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.718	6
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.702	6
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.621	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:O60443 GSDME	18	GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) G199E [cytosol] (R-HSA-9710427)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P70196 Traf6	1	Traf6 [cytosol] (R-MMU-933459)	0.499	4
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2

Cite Us!