Reactome | NFKB1(1-968) [cytosol]

NFKB1(1-968) [cytosol]

Stable Identifier

R-HSA-451607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NFKB1, NFkB p105, Nuclear factor NF-kappa-B p105 subunit

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Locations in the PathwayBrowser for interactor UniProt:Q9UKB1 FBXW11

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External Reference Information

External Reference

UniProt:P19838 NFKB1

Gene Names

NFKB1

Chain

chain:1-968, chain:1-433

Reference Genes

BioGPS Gene:4790 NFKB1

COSMIC (genes):NFKB1 NFKB1

CTD Gene:4790 NFKB1

dbSNP Gene:4790 NFKB1

ENSEMBL:ENSG00000109320 NFKB1

HGNC:7794 NFKB1

KEGG Gene (Homo sapiens):4790 NFKB1

Monarch:4790 NFKB1

NCBI Gene:4790 NFKB1

OMIM:164011 NFKB1

UCSC:P19838 NFKB1

Reference Transcript

Other Identifiers

0003130142

11717542_a_at

1377_at

1378_g_at

16969300

209239_at

2737731

2737732

2737737

2737740

2737743

2737745

2737753

2737756

2737757

2737758

2737759

2737762

2737763

2737765

2737770

2737771

2737772

2737773

2737775

2737776

2737781

2737783

2737784

2737789

2737790

2737791

2737793

2737796

2737797

38438_at

4790

8096635

A_23_P30024

GE57992

GO:0000122

GO:0000228

GO:0000790

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001818

GO:0002223

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006355

GO:0006357

GO:0006366

GO:0006464

GO:0006629

GO:0006810

GO:0006915

GO:0006950

GO:0006954

GO:0007165

GO:0007249

GO:0007267

GO:0008092

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0010629

GO:0010744

GO:0010884

GO:0010956

GO:0010957

GO:0016192

GO:0030154

GO:0031293

GO:0031410

GO:0032269

GO:0032375

GO:0032481

GO:0032991

GO:0033256

GO:0034097

GO:0034641

GO:0034774

GO:0035580

GO:0035994

GO:0038061

GO:0038095

GO:0042802

GO:0042805

GO:0043066

GO:0043226

GO:0043312

GO:0043565

GO:0044212

GO:0044281

GO:0045083

GO:0045087

GO:0045892

GO:0045893

GO:0045944

GO:0050728

GO:0050852

GO:0051092

GO:0051403

GO:0070498

GO:0071222

GO:0071260

GO:0071316

GO:0071347

GO:0071354

GO:0071356

GO:0071359

GO:0090263

GO:1900127

GO:1904385

GO:2000630

ILMN_1714965

M58603_at

PH_hs_0022751

TC04000526.hg

g189179_3p_at

Participant Of

input

NFKB p105, TPL2 (COT) and ABIN2 form a stable complex

hasComponent

Other forms of this molecule

NFKB1(1-968) [specific granule lumen]

NFKB1(1-968) [extracellular region]

NFKB1(1-968) [secretory granule lumen]

NFKB1(1-433) [nucleoplasm]

NFKB1(1-433) [cytosol]

p-S927,S932-NFKB1(1-968) [cytosol]

3xUb-p-S927,S932-NFKB1(1-968) [cytosol]

Inferred To

NFKB1(1-968) [cytosol] (Bos taurus)

NFKB1(1-968) [cytosol] (Sus scrofa)

Rel [cytosol] (Drosophila melanogaster)

nfkb1 [cytosol] (Xenopus tropicalis)

NFKB1 [cytosol] (Gallus gallus)

Nfkb1 [cytosol] (Mus musculus)

Nfkb1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001158884.1, NP_003989.2, NP_001306155.1

OpenTargets

ENSG00000109320

ZINC - Substances

NFKB1_HUMAN

ZINC - Biogenic

NFKB1_HUMAN

ZINC target

P19838

PRO

P19838

PDB

2O61, 1MDI, 1MDK, 1SVC, 2DBF, 1MDJ, 3GUT, 1NFI

ZINC - Metabolites

NFKB1_HUMAN

HPA

ENSG00000109320-NFKB1

GeneCards

P19838

Ensembl

ENST00000394820, ENST00000226574, ENSP00000469340, ENSP00000378297, ENSP00000226574, ENST00000600343, ENSG00000109320, ENST00000505458, ENSP00000424790

ZINC - Predictions - Purchasable

NFKB1_HUMAN

Orphanet

23358

HMDB Protein

HMDBP02145

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41279 MAP3K8	4	p-S400-MAP3K8 [cytosol] (R-HSA-5684308) p-S400-MAP3K8 [cytosol] (R-HSA-389738) MAP3K8 [cytosol] (R-HSA-389388) p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259)	0.897	13
UniProt:P25963 NFKBIA	10	p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) PolyUb-NFKBIA [cytosol] (R-HSA-6782960) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) NFKBIA [cytosol] (R-HSA-168151) Ub-21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929) SUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935)	0.88	7
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468)	0.875	12
UniProt:P19838 NFKB1	8	NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.764	7
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.744	7
UniProt:O14920 IKBKB	3	p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114)	0.722	3
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.713	3
UniProt:Q01201 RELB	2	RELB [cytosol] (R-HSA-5607652) RELB [nucleoplasm] (R-HSA-5607656)	0.678	3
UniProt:Q00653 NFKB2	8	NFKB2(1-900) [cytosol] (R-HSA-2677931) SUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol] (R-HSA-4755500) p52 [cytosol] (R-HSA-5607634) p52 [nucleoplasm] (R-HSA-5607655) NFKB2(1-454) [nucleoplasm] (R-HSA-177674) NFKB2(1-454) [cytosol] (R-HSA-168144) K48-polyUb-p-7S-p100 [cytosol] (R-HSA-5607636) p-7S-p100 [cytosol] (R-HSA-5607629)	0.678	6
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.667	3
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.667	5
IntAct:EBI-9870239 IKK			0.623	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.623	5
UniProt:Q04864 REL	2	REL [nucleoplasm] (R-HSA-1168585) REL [cytosol] (R-HSA-1168579)	0.564	5
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.564	3
UniProt:O60271 SPAG9	1	SPAG9 [cytosol] (R-HSA-375975)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:P35606 COPB2	4	COPB2 [Golgi membrane] (R-HSA-6808739) COPB2 [endoplasmic reticulum membrane] (R-HSA-6810957) COPB2 [cytosol] (R-HSA-199972) COPB2 [transport vesicle] (R-HSA-6808741)	0.547	3
UniProt:Q92905 COPS5	2	COPS5 [cytosol] (R-HSA-416963) COPS5 [nucleoplasm] (R-HSA-5697019)	0.547	2
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.547	4
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.547	5
UniProt:P10226 PAP			0.524	4
UniProt:Q8IV08 PLD3	2	PLD3 [plasma membrane] (R-HSA-2029042) PLD3 [endoplasmic reticulum membrane] (R-HSA-1498798)	0.524	2
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.524	2
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.508	2
UniProt:Q92887 ABCC2	5	ABCC2 R1066* [plasma membrane] (R-HSA-5679021) ABCC2 R768W [plasma membrane] (R-HSA-5679033) ABCC2 R1150H [plasma membrane] (R-HSA-5679024) ABCC2 I1173F [plasma membrane] (R-HSA-5679030) ABCC2 [plasma membrane] (R-HSA-375571)	0.508	3
UniProt:P08563-PRO_0000041302			0.463	2
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.462	4
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.462	4

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