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NFKB1(1-968) [cytosol]
Stable Identifier
R-HSA-451607
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NFKB1, NFkB p105, Nuclear factor NF-kappa-B p105 subunit
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9UKB1 FBXW11
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1(1-968) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19838 NFKB1
Gene Names
NFKB1
Chain
chain:1-968, chain:1-433
Reference Genes
BioGPS Gene:4790 NFKB1
COSMIC (genes):NFKB1 NFKB1
CTD Gene:4790 NFKB1
dbSNP Gene:4790 NFKB1
ENSEMBL:ENSG00000109320 NFKB1
HGNC:7794 NFKB1
KEGG Gene (Homo sapiens):4790 NFKB1
Monarch:4790 NFKB1
NCBI Gene:4790 NFKB1
OMIM:164011 NFKB1
UCSC:P19838 NFKB1
Reference Transcript
RefSeq:NM_001319226.1 NFKB1
RefSeq:NM_001165412.1 NFKB1
RefSeq:NM_003998.3 NFKB1
Other Identifiers
0003130142
11717542_a_at
1377_at
1378_g_at
16969300
209239_at
2737731
2737732
2737737
2737740
2737743
2737745
2737753
2737756
2737757
2737758
2737759
2737762
2737763
2737765
2737770
2737771
2737772
2737773
2737775
2737776
2737781
2737783
2737784
2737789
2737790
2737791
2737793
2737796
2737797
38438_at
4790
8096635
A_23_P30024
GE57992
GO:0000122
GO:0000228
GO:0000790
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001818
GO:0002223
GO:0002376
GO:0003674
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006355
GO:0006357
GO:0006366
GO:0006464
GO:0006629
GO:0006810
GO:0006915
GO:0006950
GO:0006954
GO:0007165
GO:0007267
GO:0008092
GO:0008134
GO:0008150
GO:0008219
GO:0009058
GO:0010629
GO:0010744
GO:0010884
GO:0010956
GO:0010957
GO:0016192
GO:0030154
GO:0031293
GO:0031410
GO:0032269
GO:0032375
GO:0032481
GO:0032695
GO:0032991
GO:0033256
GO:0034641
GO:0034774
GO:0035580
GO:0035994
GO:0038095
GO:0042025
GO:0042802
GO:0042805
GO:0043066
GO:0043226
GO:0043312
GO:0043565
GO:0044281
GO:0045892
GO:0045893
GO:0045944
GO:0050728
GO:0050852
GO:0051092
GO:0051403
GO:0070498
GO:0071222
GO:0071260
GO:0071316
GO:0071347
GO:0071354
GO:0071356
GO:0071359
GO:0090263
GO:1900127
GO:1904385
GO:2000630
ILMN_1714965
M58603_at
PH_hs_0022751
TC04000526.hg
g189179_3p_at
Participant Of
hasComponent
NFKB1:MAP3K8:TNIP2 [cytosol]
NFKB1:p-S400-MAP3K8:TNIP2 [cytosol]
NFKB1:p-T290-MAP3K8:TNIP2 [cytosol]
input
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
Other forms of this molecule
NFKB1(1-968) [specific granule lumen]
NFKB1(1-968) [extracellular region]
NFKB1(1-968) [secretory granule lumen]
NFKB1(1-433) [nucleoplasm]
NFKB1(1-433) [cytosol]
p-S927,S932-NFKB1(1-968) [cytosol]
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
Inferred To
NFKB1(1-968) [cytosol] (Sus scrofa)
Rel [cytosol] (Drosophila melanogaster)
NFKB1 [cytosol] (Gallus gallus)
Nfkb1 [cytosol] (Mus musculus)
Nfkb1 [cytosol] (Rattus norvegicus)
ccdc71l [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_003989.2
,
NP_001306155.1
,
NP_001158884.1
OpenTargets
ENSG00000109320
ZINC - Substances
NFKB1_HUMAN
ZINC - Biogenic
NFKB1_HUMAN
ZINC target
P19838
PRO
P19838
PDB
1MDK
,
1MDI
,
2O61
,
2DBF
,
3GUT
,
1MDJ
,
1NFI
,
1SVC
ZINC - Metabolites
NFKB1_HUMAN
GeneCards
P19838
HPA
ENSG00000109320-NFKB1
Ensembl
ENSP00000469340
,
ENST00000600343
,
ENST00000505458
,
ENSP00000424790
,
ENSG00000109320
,
ENST00000394820
,
ENSP00000378297
,
ENST00000226574
,
ENSP00000226574
Orphanet
23358
ZINC - Predictions - Purchasable
NFKB1_HUMAN
HMDB Protein
HMDBP02145
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41279 MAP3K8
4
p-S400-MAP3K8 [cytosol]
(R-HSA-5684308)
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
0.897
13
UniProt:P25963 NFKBIA
10
SUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
NFKBIA [cytosol]
(R-HSA-168151)
Ub-21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
0.88
7
UniProt:Q04206 RELA
6
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
SUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
0.875
12
UniProt:P19838 NFKB1
8
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.764
7
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.744
7
UniProt:O14920 IKBKB
3
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
0.722
3
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.713
3
UniProt:Q00653 NFKB2
8
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
SUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
p52 [nucleoplasm]
(R-HSA-5607655)
p52 [cytosol]
(R-HSA-5607634)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
0.678
6
UniProt:Q01201 RELB
2
RELB [cytosol]
(R-HSA-5607652)
RELB [nucleoplasm]
(R-HSA-5607656)
0.678
3
UniProt:Q13547 HDAC1
2
SUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
HDAC1 [nucleoplasm]
(R-HSA-205021)
0.667
5
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.667
3
IntAct:EBI-9870239 IKK
0.623
2
UniProt:P23396 RPS3
2
RPS3 [cytosol]
(R-HSA-72369)
RPS3 [nucleoplasm]
(R-HSA-6798714)
0.623
5
UniProt:Q04864 REL
2
REL [nucleoplasm]
(R-HSA-1168585)
REL [cytosol]
(R-HSA-1168579)
0.564
5
UniProt:P34931 HSPA1L
2
HSPA1L [nucleoplasm]
(R-HSA-5082367)
HSPA1L [cytosol]
(R-HSA-3371410)
0.564
3
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.564
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
3
UniProt:P35606 COPB2
4
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [cytosol]
(R-HSA-199972)
COPB2 [Golgi membrane]
(R-HSA-6808739)
0.547
3
UniProt:Q92905 COPS5
2
COPS5 [cytosol]
(R-HSA-416963)
COPS5 [nucleoplasm]
(R-HSA-5697019)
0.547
2
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.547
4
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.547
5
UniProt:P10226 PAP
0.524
4
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.524
2
UniProt:Q8IV08 PLD3
2
PLD3 [plasma membrane]
(R-HSA-2029042)
PLD3 [endoplasmic reticulum membrane]
(R-HSA-1498798)
0.524
2
UniProt:Q14690 PDCD11
1
PDCD11 [nucleoplasm]
(R-HSA-6790646)
0.508
2
UniProt:Q92887 ABCC2
5
ABCC2 R1066* [plasma membrane]
(R-HSA-5679021)
ABCC2 R768W [plasma membrane]
(R-HSA-5679033)
ABCC2 R1150H [plasma membrane]
(R-HSA-5679024)
ABCC2 I1173F [plasma membrane]
(R-HSA-5679030)
ABCC2 [plasma membrane]
(R-HSA-375571)
0.508
3
UniProt:P08563-PRO_0000041302
0.463
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.462
4
UniProt:Q9Y297 BTRC
2
BTRC [nucleoplasm]
(R-HSA-3361753)
BTRC [cytosol]
(R-HSA-174237)
0.462
4
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