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NFKB1:MAP3K8:TNIP2 [cytosol]
Stable Identifier
R-HSA-451638
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
NFKB p105:TPL2:ABIN2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
NFKB1:MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Participants
components
MAP3K8 [cytosol]
(Homo sapiens)
NFKB1(1-968) [cytosol]
(Homo sapiens)
TNIP2 [cytosol]
(Homo sapiens)
Participates
as an input of
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
MAP3K8 is phosphorylated (Homo sapiens)
as an output of
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)
Inferred To
NFKB1:MAP3K8:TNIP2 [cytosol]
(Bos taurus)
NFKB1:MAP3K8:TNIP2 [cytosol]
(Canis familiaris)
NFKB1:MAP3K8:TNIP2 [cytosol]
(Gallus gallus)
NFKB1:MAP3K8:TNIP2 [cytosol]
(Mus musculus)
NFKB1:MAP3K8:TNIP2 [cytosol]
(Sus scrofa)
NFKB1:MAP3K8:TNIP2 [cytosol]
(Xenopus tropicalis)
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