Reactome | TNIP2 [cytosol]

TNIP2 [cytosol]

Stable Identifier

R-HSA-451661

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ABIN2, TNFAIP3-interacting protein 2, TNIP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NFZ5 TNIP2

Gene Names

TNIP2, ABIN2, FLIP1

Chain

chain:1-429

Reference Genes

BioGPS Gene:79155 TNIP2

COSMIC (genes):TNIP2 TNIP2

CTD Gene:79155 TNIP2

dbSNP Gene:79155 TNIP2

ENSEMBL:ENSG00000168884 TNIP2

HGNC:19118 TNIP2

KEGG:hsa:79155 TNIP2

Monarch:79155 TNIP2

NCBI Gene:79155 TNIP2

OMIM:610669 TNIP2

UCSC:Q8NFZ5 TNIP2

Reference Transcript

Other Identifiers

11735290_a_at

16973758

218335_PM_x_at

218335_x_at

232160_PM_s_at

232160_s_at

2757945

2757946

2757947

2757949

2757950

2757951

2757952

2757955

2757956

2757957

2757958

2757959

2757962

2757963

2757964

2757965

4005732

48531_PM_at

48531_at

4865827C_3p_s_at

79155

8099029

A_23_P258418

GE56667

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006915

GO:0006954

GO:0012501

GO:0019901

GO:0023035

GO:0031593

GO:0034134

GO:0034138

GO:0034162

GO:0043032

GO:0043122

GO:0043123

GO:0043226

GO:0045944

GO:0046872

GO:0050821

GO:0050871

GO:0070498

GO:0070530

GO:0071222

GO:2000352

HMNXSV003030999

ILMN_2168933

PH_hs_0032668

TC04000977.hg

Participates

as a member of

TNIPs [cytosol] (Homo sapiens)

as a component of

as an input of

NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Homo sapiens)

as an output of

3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Homo sapiens)

Inferred To

TNIP2 [cytosol] (Bos taurus)

TNIP2 [cytosol] (Canis familiaris)

TNIP2 [cytosol] (Gallus gallus)

TNIP2 [cytosol] (Mus musculus)

TNIP2 [cytosol] (Sus scrofa)

Tnip2 [cytosol] (Rattus norvegicus)

HDA2 [cytosol] (Saccharomyces cerevisiae)

tnip2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001278945.1, NP_001154999.1, NP_077285.3

ENSEMBL

ENSP00000427613, ENST00000315423, ENST00000510267, ENSP00000321203

OpenTargets

ENSG00000168884

HPA

ENSG00000168884-TNIP2

PRO

Q8NFZ5

Pharos - Targets

Q8NFZ5

GlyGen

Q8NFZ5

PDB

5H07

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41279 MAP3K8	3	p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259) MAP3K8 [cytosol] (R-HSA-389388) p-S400-MAP3K8 [cytosol] (R-HSA-389738)	0.774	10
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.764	8
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.689	7
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.688	5
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.683	5
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.669	3
UniProt:P19838-1 NFKB1			0.653	8
UniProt:Q6GQQ9 OTUD7B	1	OTUD7B [cytosol] (R-HSA-5212662)	0.547	2
UniProt:Q9UBP4 DKK3			0.527	3
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.527	3
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.527	3
UniProt:Q86YS3 RFIP4			0.527	2
UniProt:Q8IYS4 DAAF8			0.527	2
UniProt:O60232 ZNRD2			0.527	2
UniProt:Q92844 TANK	2	K63polyUb-TANK [cytosol] (R-HSA-5362480) TANK [cytosol] (R-HSA-933407)	0.527	3