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p85 associates with both p-Nephrin and CD2AP
Stable Identifier
R-HSA-451758
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The regulatory p85 subunit of PI3K recognizes and binds to both phosphorylated nephrin and its binding partner, CD2AP. By mutation analysis, nephrin Y1158 was shown to be necessary for the interaction. This interaction allows the catalytic subunit p110 to act on phospholipids of the inner leaflet of the cell membrane. This leads to downstream phosphorylation and inactivation of the apoptotic factor Bad via the serine-threonine kinase AKT.
Participants
Input
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane]
(Homo sapiens)
PI3K [cytosol]
(Homo sapiens)
Output
PI3K:CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane]
(Homo sapiens)
Entity On Other Cell
NPHS1-1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Nephrin family interactions (Homo sapiens)
Inferred From
p85 associates with both p-Nephrin and CD2AP (Rattus norvegicus)
Authored
Garapati, P V (2008-02-26)
de Bono, B (2008-02-26)
Reviewed
Grahammer, Florian (2010-05-20)
Huber, TB (2010-05-20)
Created
Garapati, P V (2010-01-11)
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