NLK mRNA translation controlled by miR-92b

Stable Identifier
R-HSA-4518585
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Translation of NLK mRNA is controlled by miR-92b. miR-92b binds the 3' UTR of NLK mRNA and promotes its degradation, resulting in decreased NLK protein levels. In this way, miR-92b positively regulates canonical TCF/LEF- and beta-catenin-dependent WNT signaling (Wang et al, 2013).

Literature References
PubMed ID Title Journal Year
23416699 miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase

Wang, K, Wang, X, Zou, J, Zhang, A, Wan, Y, Pu, P, Song, Z, Qian, C, Chen, Y, Yang, S, Wang, Y

Neuro-oncology 2013
Participants
Participant Of
hasEvent
This event is regulated
Authored
Reviewed
Created