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Table of Contents
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JAK3 [cytosol]
Stable Identifier
R-HSA-451893
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase JAK3, JAK3_HUMAN, Janus kinase 3
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
PTK2B binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:PYK2 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
PTK2B is phosphorylated (Homo sapiens)
JAK3:PYK2 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:p-PYK2 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated STAT5 is released (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Recruited STAT5 is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
SYK binds IL2RB (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
SYK is a substrate for JAK1 (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-21 signaling (Homo sapiens)
IL21 receptor JAK phosphorylation (Homo sapiens)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-9 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)
IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Homo sapiens)
JAK2, JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK2, JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Homo sapiens)
JAK2, JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:IL4R:JAK2 binds IL2RG:JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK1 binds IL4R in IL4-bound IL4R1 (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Homo sapiens)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Homo sapiens)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52333 JAK3
Gene Names
JAK3
Chain
chain:1-1124
Reference Genes
BioGPS Gene:3718 JAK3
COSMIC (genes):JAK3 JAK3
CTD Gene:3718 JAK3
dbSNP Gene:3718 JAK3
ENSEMBL:ENSG00000105639 JAK3
HGNC:6193 JAK3
KEGG Gene (Homo sapiens):3718 JAK3
Monarch:3718 JAK3
NCBI Gene:3718 JAK3
OMIM:600173 JAK3
UCSC:P52333 JAK3
Reference Transcript
RefSeq:NM_000215.3 JAK3
Other Identifiers
0002760164
11727257_a_at
11750098_a_at
11750573_x_at
11752613_a_at
1547_at
16870274
2005_s_at
2006_at
2007_g_at
207187_3p_at
207187_at
211108_s_at
211109_at
227677_at
3718
3854628
3854629
3854630
3854631
3854632
3854633
3854634
3854635
3854636
3854638
3854639
3854640
3854641
3854642
3854643
3854644
3854645
3854646
3854649
3854650
3854651
3854653
3854655
3854656
3854658
3854659
3854661
3854662
3854663
3854664
3854665
3854667
46152_at
8035351
A_23_P329112
A_24_P308096
A_24_P59667
GE58907
GO:0000165
GO:0000166
GO:0002250
GO:0002376
GO:0002731
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0007155
GO:0007165
GO:0007167
GO:0007260
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0019899
GO:0019903
GO:0030154
GO:0030183
GO:0030218
GO:0031410
GO:0032693
GO:0032695
GO:0035556
GO:0035723
GO:0035771
GO:0038110
GO:0038111
GO:0038113
GO:0038114
GO:0042102
GO:0042592
GO:0042981
GO:0043029
GO:0043167
GO:0043226
GO:0045087
GO:0045221
GO:0045626
GO:0046425
GO:0048856
GO:0050868
GO:0060397
GO:0070232
GO:0070244
GO:0070669
GO:0070670
GO:0070672
GO:0071104
Hs.58643.0.A1_3p_at
ILMN_1739667
PH_hs_0023062
PH_hs_0032182
TC19001280.hg
U09607_at
g1039418_3p_at
g4557680_3p_at
Participant Of
hasCandidate
JAK2, JAK3 [cytosol]
input
IL2RG binds JAK3
JAK3 binds JAK3 inhibitors
PTK2B binds JAK3
hasComponent
IL2RG:JAK3 [plasma membrane]
JAK3:JAK3 inhibitors [cytosol]
JAK3:p-PYK2 [cytosol]
JAK3:PYK2 [cytosol]
p-Y-IL2RG:JAK3 [plasma membrane]
Other forms of this molecule
p-Y904,939-JAK3 [plasma membrane]
JAK3 [endosome]
p-JAK3 [cytosol]
p-Y-JAK3 [cytosol]
Inferred To
JAK3 [cytosol] (Bos taurus)
JAK3 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Sus scrofa)
JAK3 [cytosol] (Xenopus tropicalis)
jak2a [cytosol] (Danio rerio)
Jak3 [cytosol] (Mus musculus)
Jak3 [cytosol] (Rattus norvegicus)
hop [cytosol] (Drosophila melanogaster)
Homologues of JAK3 [cytosol] (Danio rerio)
Ghost homologue of JAK3 [cytosol] (Gallus gallus)
jak3 [cytosol] (Danio rerio)
jak2b [cytosol] (Danio rerio)
Cross References
RefSeq
NP_000206.2
ZINC - World Drugs
JAK3_HUMAN
OpenTargets
ENSG00000105639
ZINC - FDA approved
JAK3_HUMAN
ZINC - Substances
JAK3_HUMAN
ZINC - Biogenic
JAK3_HUMAN
ZINC target
P52333
PRO
P52333
PDB
3PJC
,
4HVI
,
6NY4
,
5WFJ
,
4Z16
,
4HVH
,
3ZC6
,
6DUD
,
3LXL
,
4HVG
,
5TOZ
,
5VO6
,
4I6Q
,
6AAK
,
5W86
,
1YVJ
,
6GLA
,
4HVD
,
4QPS
,
4RIO
,
7C3N
,
6DA4
,
4V0G
,
5TTV
,
6GL9
,
5TTU
,
4QT1
,
3LXK
,
6GLB
,
3ZEP
,
6DB4
,
5TTS
,
5LWN
,
6HZV
,
5LWM
,
6DB3
ZINC - Investigational
JAK3_HUMAN
IntEnz
2.7.10.2
HPA
ENSG00000105639-JAK3
GeneCards
P52333
Ensembl
ENSP00000436421
,
ENST00000527670
,
ENSP00000432511
,
ENST00000534444
,
ENST00000458235
,
ENSP00000391676
,
ENSG00000105639
ZINC - Predictions - Purchasable
JAK3_HUMAN
Orphanet
16280
HMDB Protein
HMDBP01358
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:P50990 CCT8
5
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.527
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:P55209 NP1L1
0.499
3
UniProt:Q9UNF1 MAGED2
2
MAGED2 [platelet alpha granule lumen]
(R-HSA-8862956)
MAGED2 [extracellular region]
(R-HSA-8862948)
0.499
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.488
2
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