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JAK3 [cytosol]
Stable Identifier
R-HSA-451893
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase JAK3, JAK3_HUMAN, Janus kinase 3
Icon
Locations in the PathwayBrowser for interactor UniProt:P17987
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
PTK2B binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-9 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
Active ALK binds JAK3 (Homo sapiens)
JAK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52333 JAK3
Gene Names
JAK3
Chain
chain:1-1124
Reference Genes
BioGPS Gene:3718 JAK3
COSMIC (genes):JAK3 JAK3
CTD Gene:3718 JAK3
dbSNP Gene:3718 JAK3
ENSEMBL:ENSG00000105639 JAK3
ENSEMBL_homo_sapiens_GENE:ENSG00000105639.21 JAK3
HGNC:6193 JAK3
KEGG Gene (Homo sapiens):3718 JAK3
Monarch:3718 JAK3
NCBI Gene:3718 JAK3
OMIM:600173 JAK3
UCSC:P52333 JAK3
Reference Transcript
RefSeq:NM_000215.3 JAK3
Other Identifiers
11727257_a_at
11750098_a_at
11750573_x_at
11752613_a_at
1547_at
16870274
2005_s_at
2006_at
2007_g_at
207187_3p_at
207187_PM_at
207187_at
211108_PM_s_at
211108_s_at
211109_PM_at
211109_at
227677_PM_at
227677_at
3718
3854628
3854629
3854630
3854631
3854632
3854633
3854634
3854635
3854636
3854638
3854639
3854640
3854641
3854642
3854643
3854644
3854645
3854646
3854649
3854650
3854651
3854653
3854655
3854656
3854658
3854659
3854661
3854662
3854663
3854664
3854665
3854667
46152_at
8035351
A_23_P329112
A_24_P308096
A_24_P59667
GE58907
GO:0000166
GO:0002250
GO:0002376
GO:0002731
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005515
GO:0005524
GO:0005737
GO:0005768
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0007155
GO:0007167
GO:0007259
GO:0007260
GO:0012501
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019221
GO:0019897
GO:0019903
GO:0023052
GO:0030154
GO:0030183
GO:0031234
GO:0031410
GO:0032693
GO:0032695
GO:0035556
GO:0035723
GO:0035771
GO:0036211
GO:0038110
GO:0038113
GO:0042981
GO:0043029
GO:0043226
GO:0045087
GO:0045221
GO:0045626
GO:0046425
GO:0048856
GO:0050868
GO:0060397
GO:0070232
GO:0070244
GO:0070669
GO:0070670
GO:0070672
GO:0071104
GO:0098542
GO:0140096
GO:1901135
HMNXSV003018899
Hs.58643.0.A1_3p_at
ILMN_1739667
PH_hs_0023062
PH_hs_0032182
TC19001280.hg
U09607_at
g1039418_3p_at
g4557680_3p_at
Participates
as a candidate of
JAK2, JAK3 [cytosol] (Homo sapiens)
as an input of
Active ALK binds JAK3 (Homo sapiens)
PTK2B binds JAK3 (Homo sapiens)
JAK3 binds JAK3 inhibitors (Homo sapiens)
IL2RG binds JAK3 (Homo sapiens)
as a component of
Active ALK:JAK3 [plasma membrane] (Homo sapiens)
JAK3:p-PYK2 [cytosol] (Homo sapiens)
JAK3:PYK2 [cytosol] (Homo sapiens)
p-Y-IL2RG:JAK3 [plasma membrane] (Homo sapiens)
JAK3:JAK3 inhibitors [cytosol] (Homo sapiens)
IL2RG:JAK3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y980 JAK3 [cytosol]
JAK3 [endosome]
p-JAK3 [cytosol]
p-Y-JAK3 [cytosol]
p-Y904,939-JAK3 [plasma membrane]
Inferred To
JAK3 [cytosol]
(Bos taurus)
JAK3 [cytosol]
(Canis familiaris)
JAK3 [cytosol]
(Drosophila melanogaster)
JAK3 [cytosol]
(Mus musculus)
JAK3 [cytosol]
(Rattus norvegicus)
JAK3 [cytosol]
(Sus scrofa)
JAK3 [cytosol]
(Xenopus tropicalis)
Ghost homologue of JAK3 [cytosol]
(Danio rerio)
Ghost homologue of JAK3 [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_000206.2
ZINC - World Drugs
JAK3_HUMAN
Guide to Pharmacology - Targets
2049
OpenTargets
ENSG00000105639
ZINC - FDA approved
JAK3_HUMAN
ZINC - Substances
JAK3_HUMAN
ZINC - Biogenic
JAK3_HUMAN
ZINC target
P52333
PRO
P52333
PDB
8EXM
,
7APF
,
7APG
,
7UYV
,
7C3N
,
3ZEP
,
4Z16
,
6GL9
,
6DB4
,
6DB3
,
5LWM
,
6GLA
,
4QT1
,
5TTS
,
4HVI
,
3PJC
,
4HVH
,
5LWN
,
6GLB
,
5TTU
,
6DA4
,
4HVG
,
5TTV
,
1YVJ
,
4HVD
,
4I6Q
,
3LXL
,
3ZC6
,
6DUD
,
4V0G
,
6HZV
,
5VO6
,
4QPS
,
3LXK
,
6AAK
,
5W86
,
6NY4
,
4RIO
,
5TOZ
,
7Q6H
,
5WFJ
ZINC - Investigational
JAK3_HUMAN
HPA
ENSG00000105639-JAK3
GeneCards
P52333
Ensembl
ENSG00000105639
,
ENST00000458235
,
ENST00000527670
,
ENSP00000432511
,
ENSP00000391676
,
ENST00000534444
,
ENSP00000436421
Pharos - Targets
P52333
Orphanet
16280
ZINC - Predictions - Purchasable
JAK3_HUMAN
HMDB Protein
HMDBP01358
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55209 NP1L1
0.623
4
UniProt:Q9UNF1 MAGED2
2
MAGED2 [extracellular region]
(R-HSA-8862948)
MAGED2 [platelet alpha granule lumen]
(R-HSA-8862956)
0.623
4
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:O95071 UBR5
0.527
2
UniProt:P50990 CCT8
5
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [cytosol]
(R-HSA-390449)
0.527
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
2
UniProt:Q99733 NP1L4
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:Q5JWF2 GNAS
1
GNAS1 [plasma membrane]
(R-HSA-8873940)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.488
2
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