Reactome: A Curated Pathway Database

Recruited STAT5 is phosphorylated

Stable Identifier
R-HSA-452097
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Summation

STAT5 alpha and beta are recruited to the receptor complex and phosphorylated. JAK3 is believed to be responsible for the tyrosine phosphorylation of STAT5 in response to IL-2; it is not clear whether JAK1 is also involved (Lin & Leonard, 2000). Tyr-694 of STAT5a and Tyr-699 of STAT5b are required for IL-2 induced STAT5 activation (Lin et al. 1996). STAT5a and STAT5b are also known to be serine phosphorylated in lymphocytes activated by IL-2 but the funtion of this is unclear (Xue et al. 2002).

Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15 Proc Natl Acad Sci U S A 1995
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events
 
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