Recruited STAT5 is phosphorylated

Stable Identifier
R-HSA-452097
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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STAT5 alpha and beta are recruited to the receptor complex and phosphorylated. JAK3 is believed to be responsible for the tyrosine phosphorylation of STAT5 in response to IL-2; it is not clear whether JAK1 is also involved (Lin & Leonard, 2000). Tyr-694 of STAT5a and Tyr-699 of STAT5b are required for IL-2 induced STAT5 activation (Lin et al. 1996). STAT5a and STAT5b are also known to be serine phosphorylated in lymphocytes activated by IL-2 but the funtion of this is unclear (Xue et al. 2002).

Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Johnston, JA, Bacon, CM, Finbloom, DS, Rees, RC, Kaplan, D, Shibuya, K, Ortaldo, JR, Gupta, S, Chen, YQ, Giri, JD

Proc Natl Acad Sci U S A 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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