Phosphorylated STAT5A and STAT5B form homodimers and heterodimers in the cytosol (Gaffen et al. 1996, Rosenthal et al. 1997, also inferred from mouse homologs). Phosphorylation of a critical tyrosine residue in the SH domain (Y694 in STAT5A and Y699 in STAT5B) and intramolecular interactions between hydrophobic residues in the SH domain are required for dimerization (inferred from mouse homologs).
Gaffen, SL, Lai, SY, Ha, M, Liu, X, Hennighausen, L, Greene, WC, Goldsmith, MA
Rosenthal, LA, Winestock, KD, Finbloom, DS
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