Reactome | SOX2 [nucleoplasm]

SOX2 [nucleoplasm]

Stable Identifier

R-HSA-452271

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor SOX-2, SOX2_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Deactivation of the beta-catenin transactivating complex (Homo sapiens)
      - Beta-catenin binds SOX proteins (Homo sapiens)
        
        CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SOX2 [nucleoplasm] (Homo sapiens)
        
        SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SOX2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48431 SOX2

Gene Names

SOX2

Chain

chain:1-317

Reference Genes

BioGPS Gene:6657 SOX2

COSMIC (genes):SOX2 SOX2

CTD Gene:6657 SOX2

dbSNP Gene:6657 SOX2

ENSEMBL:ENSG00000181449.4 SOX2

HGNC:11195 SOX2

KEGG Gene (Homo sapiens):6657 SOX2

Monarch:6657 SOX2

NCBI Gene:6657 SOX2

OMIM:184429 SOX2

UCSC:P48431 SOX2

Reference Transcript

RefSeq:NM_003106.3 SOX2

Other Identifiers

0005900402

11720991_s_at

11720992_a_at

11720993_at

16948461

213721_PM_at

213721_at

213722_PM_at

213722_at

228038_PM_at

228038_at

2654505

2654506

2654507

2654508

2654509

2654510

2654511

3114577

3114580

33108_i_at

33109_f_at

3502004

43431_at

57685_at

6657

8084165

89217_at

A_14_P103493

A_14_P132639

A_14_P202174

A_23_P401055

A_24_P379969

GE57573

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0001649

GO:0001654

GO:0001714

GO:0003674

GO:0003677

GO:0003700

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006351

GO:0006355

GO:0007155

GO:0008150

GO:0009611

GO:0009653

GO:0010468

GO:0021781

GO:0021983

GO:0021984

GO:0022409

GO:0023052

GO:0030154

GO:0030900

GO:0032991

GO:0035019

GO:0035198

GO:0042246

GO:0043226

GO:0043281

GO:0043410

GO:0043565

GO:0045165

GO:0045597

GO:0045665

GO:0045893

GO:0045944

GO:0048731

GO:0048839

GO:0048856

GO:0050680

GO:0070848

GO:0090090

GO:0097150

GO:1902807

HMNXSV003037365

Hs.129911.0.A1_3p_at

Hs.816.0.A1_3p_at

Hs.816.0.A2_3p_at

ILMN_1658440

ILMN_1770635

ILMN_2177156

PH_hs_0000096

TC03000969.hg

Z31560_s_at

Participates

as a component of

as an input of

as an output of

as a member of

Inferred To

sox-4 [nucleoplasm] (Caenorhabditis elegans)

Sox21b [nucleoplasm] (Drosophila melanogaster)

Sox14 [nucleoplasm] (Drosophila melanogaster)

sem-2 [nucleoplasm] (Caenorhabditis elegans)

Sox21a [nucleoplasm] (Drosophila melanogaster)

SoxN [nucleoplasm] (Drosophila melanogaster)

sox2 [nucleoplasm] (Danio rerio)

D [nucleoplasm] (Drosophila melanogaster)

sox-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SOX2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SOX2 [nucleoplasm] (Drosophila melanogaster)

Sox2 [nucleoplasm] (Mus musculus)

Sox2 [nucleoplasm] (Rattus norvegicus)

sox-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003097.1

OpenTargets

ENSG00000181449

HPA

ENSG00000181449-SOX2

GeneCards

P48431

Ensembl

ENSG00000181449, ENST00000325404, ENSP00000323588

PRO

P48431

Pharos - Targets

P48431

Orphanet

15540

PDB

6WX8, 6T7B, 6WX7, 6T90, 1O4X, 2LE4, 6YOV, 6WX9

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.666	4
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.61	14
UniProt:Q01860 POU5F1	1	POU5F1 [nucleoplasm] (R-HSA-452472)	0.564	2
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.536	2
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.527	2
UniProt:P13010 XRCC5	4	XRCC5 [cytosol] (R-HSA-3134849) XRCC5 [extracellular region] (R-HSA-6806530) XRCC5 [secretory granule lumen] (R-HSA-6801297) XRCC5 [nucleoplasm] (R-HSA-58274)	0.527	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.499	3
UniProt:Q9P2D1 CHD7			0.483	2
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.483	2
UniProt:Q99856 ARID3A	1	ARID3A [nucleoplasm] (R-HSA-3782552)	0.483	2
UniProt:O15090 ZN536			0.483	2
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.483	2
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.483	2
UniProt:O14497 ARID1A	1	ARID1A [nucleoplasm] (R-HSA-389259)	0.483	2
UniProt:Q12948 FOXC1			0.483	2
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.483	2
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.483	2
UniProt:Q9BYN8 MRPS26	1	MRPS26 [mitochondrial inner membrane] (R-HSA-5368265)	0.483	2
UniProt:Q13610 PWP1			0.483	2
UniProt:Q9Y221 NIP7	1	NIP7 [nucleoplasm] (R-HSA-6797236)	0.483	2
UniProt:Q9UQE7 SMC3	6	SMC3 [cytosol] (R-HSA-2545223) 2xAcK-SMC3 [cytosol] (R-HSA-2484792) 2xAcK-SMC3 [chromosome] (R-HSA-2468146) 2xAcK-SMC3 [chromosome, centromeric region] (R-HSA-2468148) 2xAcK-SMC3 [nucleoplasm] (R-HSA-2468050) SMC3 [nucleoplasm] (R-HSA-163009)	0.483	2
UniProt:O76094 SRP72	1	SRP72 [cytosol] (R-HSA-265069)	0.483	2
UniProt:Q9H582 ZN644			0.483	2
UniProt:Q8IVH2 FOXP4			0.483	2
UniProt:Q01167 FOXK2	1	FOXK2 [nucleoplasm] (R-HSA-5689655)	0.483	2
UniProt:Q96JM2 ZN462			0.483	2
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.483	2
UniProt:Q8IVW6 ARI3B			0.483	2
UniProt:Q8N108 MIER1			0.483	2
UniProt:P39880 CUX1	2	CUX1(1-339)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614371) CUX1(1-339)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838991)	0.483	2
UniProt:P51531 SMARCA2	1	SMARCA2 [nucleoplasm] (R-HSA-389256)	0.483	2
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.483	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.483	2
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.483	2
UniProt:Q86UP3 ZFHX4			0.483	2
UniProt:O15014 ZN609			0.483	2
UniProt:O00712 NFIB	1	NFIB [nucleoplasm] (R-HSA-60136)	0.471	2
UniProt:P08651 NFIC	1	NFIC [nucleoplasm] (R-HSA-60138)	0.471	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.462	3

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