Reactome | MYCN [nucleoplasm]

MYCN [nucleoplasm]

Stable Identifier

R-HSA-452357

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

N-myc proto-oncogene protein, MYCN_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04198 MYCN

Gene Names

MYCN, BHLHE37, NMYC

Chain

chain:1-464

Reference Genes

BioGPS Gene:4613 MYCN

COSMIC (genes):MYCN MYCN

CTD Gene:4613 MYCN

dbSNP Gene:4613 MYCN

ENSEMBL:ENSG00000134323 MYCN

HGNC:7559 MYCN

KEGG:hsa:4613 MYCN

Monarch:4613 MYCN

NCBI Entrez Gene:4613 MYCN

OMIM:164840 MYCN

UCSC:P04198 MYCN

Reference Transcript

Other Identifiers

11719868_a_at

11719869_a_at

11719870_s_at

11750948_a_at

16877413

2078_s_at

209756_3p_s_at

209756_PM_s_at

209756_s_at

209757_PM_s_at

209757_s_at

211377_PM_x_at

211377_x_at

234376_PM_at

234376_at

2470822

2470823

2470824

2470825

2470826

2470839

2470840

2470841

2470842

2470844

2470845

2470846

2470847

2470848

2470849

2470850

2470852

2470854

35158_at

4613

8040419

A_14_P120510

A_14_P120703

A_14_P127309

A_14_P202293

A_23_P303390

A_24_P94402

GE81500

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001502

GO:0002053

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006325

GO:0006355

GO:0006357

GO:0008283

GO:0010628

GO:0010629

GO:0019900

GO:0030154

GO:0030324

GO:0042733

GO:0043068

GO:0045607

GO:0045893

GO:0045944

GO:0046983

GO:0048704

GO:0048708

GO:0048712

GO:0048754

GO:0048856

GO:0050673

GO:0050679

GO:0141068

GO:1902895

GO:1990837

GO:2000378

HMNXSV003034339

Hs.25960.1.S1_3p_a_at

Hs.25960.2.S1_3p_at

ILMN_1653761

ILMN_2219767

M13241_at

PH_hs_0002287

TC02000094.hg

g11692795_3p_a_at

g11692795_3p_x_at

g12803748_3p_a_at

Participates

as an output of

ALK-stimulated MYCN gene expression (Homo sapiens)

as a member of

MYC,MYCN [nucleoplasm] (Homo sapiens)

This entity regulates

Negatively

TGFBR3 transcription (Homo sapiens)

Inferred To

Myc [nucleoplasm] (Drosophila melanogaster)

MYCN [nucleoplasm] (Bos taurus)

MYCN [nucleoplasm] (Canis familiaris)

MYCN [nucleoplasm] (Gallus gallus)

MYCN [nucleoplasm] (Sus scrofa)

mycn [nucleoplasm] (Xenopus tropicalis)

Mycn [nucleoplasm] (Mus musculus)

Mycn [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001280160.1, XP_054198135.1, NP_001280157.1, XP_047300390.1, NP_005369.2, NP_001280162.1, XP_016859657.1

OpenTargets

ENSG00000134323

ENSEMBL

ENSP00000281043, ENSG00000134323, ENST00000281043

HPA

ENSG00000134323-MYCN

GeneCards

MYCN

PRO

P04198

Pharos - Targets

P04198

Orphanet

MYCN

GlyGen

P04198

PDB

5G1X, 7ZTL

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.844	10
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.834	12
UniProt:Q13105 ZBTB17	1	ZBTB17 [nucleoplasm] (R-HSA-535577)	0.602	3
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.564	2
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.553	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	3
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.536	3
UniProt:P97477 Aurka	7	monoSumo1-K249-Aurka [cytosol] (R-MMU-4655406) Aurka [nucleoplasm] (R-MMU-4655340) AURKA [nucleoplasm] (R-MMU-4655443) PolyUb-AURKA [cytosol] (R-MMU-8854040) phospho-p-T288-AURKA [nucleoplasm] (R-MMU-6805089) AURKA [cytosol] (R-MMU-174254) phospho-p-T288-AURKA [cytosol] (R-MMU-2574832)	0.536	2
UniProt:Q13287 NMI	1	NMI [cytosol] (R-HSA-9731022)	0.488	3
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.454	5