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WT1 [nucleoplasm]
Stable Identifier
R-HSA-452420
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Wilms tumor protein, WT1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q6A162
Expand all
Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Nephron development (Homo sapiens)
WT1 binds the PAX2 gene (Homo sapiens)
WT1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of testis differentiation (Homo sapiens)
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
WT1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19544 WT1
Gene Names
WT1
Chain
chain:1-449
Reference Genes
BioGPS Gene:7490 WT1
COSMIC (genes):WT1 WT1
CTD Gene:7490 WT1
dbSNP Gene:7490 WT1
ENSEMBL:ENSG00000184937 WT1
ENSEMBL_homo_sapiens_GENE:ENSG00000184937.16 WT1
HGNC:12796 WT1
KEGG Gene (Homo sapiens):7490 WT1
Monarch:7490 WT1
NCBI Gene:7490 WT1
OMIM:607102 WT1
UCSC:P19544 WT1
Reference Transcript
RefSeq:NM_024424.3 WT1
RefSeq:NM_001198552.1 WT1
RefSeq:NM_001198551.1 WT1
RefSeq:NM_024426.4 WT1
RefSeq:NM_000378.4 WT1
Other Identifiers
11730686_a_at
11730687_a_at
1500_at
16737105
1684_s_at
206067_PM_s_at
206067_s_at
216953_PM_s_at
216953_s_at
3368299
3368301
3368303
3368305
3368306
3368307
3368309
3368312
3368318
3368322
3368324
3368331
3368333
3368335
3368338
3368339
3368340
3368341
3368342
3368343
3368344
7490
7947363
GE59758
GE675489
GO:0000122
GO:0000976
GO:0000978
GO:0000981
GO:0001228
GO:0001570
GO:0001657
GO:0001658
GO:0001822
GO:0003156
GO:0003677
GO:0003700
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007281
GO:0007356
GO:0007507
GO:0007530
GO:0008270
GO:0008285
GO:0008380
GO:0008406
GO:0008584
GO:0009888
GO:0010385
GO:0010628
GO:0012501
GO:0016607
GO:0022414
GO:0030154
GO:0030198
GO:0030308
GO:0030325
GO:0030539
GO:0030855
GO:0032835
GO:0032836
GO:0035802
GO:0043010
GO:0043066
GO:0043226
GO:0043565
GO:0044729
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0060231
GO:0060421
GO:0060539
GO:0060923
GO:0061032
GO:0070742
GO:0071320
GO:0071371
GO:0072075
GO:0072112
GO:0072166
GO:0072207
GO:0072284
GO:0072302
GO:0140110
GO:1902895
GO:1905643
GO:2000020
GO:2000195
GO:2001076
HMNXSV003027459
Hs.1145.2.S1_3p_a_at
ILMN_1802174
ILMN_2366967
PH_hs_0000148
TC11001533.hg
TC11003109.hg
X51630_at
g13386509_3p_a_at
Participates
as an input of
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
WT1 binds the PAX2 gene (Homo sapiens)
as a component of
WT1:NR5A1:GATA4:ZFPM2:SRY gene [nucleoplasm] (Homo sapiens)
WT1:PAX2 gene [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_001185481.1
,
NP_000369.3
,
NP_077742.2
,
NP_077744.3
,
NP_001185480.1
OpenTargets
ENSG00000184937
GeneCards
P19544
HPA
ENSG00000184937-WT1
Ensembl
ENSP00000368370
,
ENSP00000435307
,
ENST00000639563
,
ENST00000379079
,
ENST00000530998
,
ENST00000452863
,
ENSP00000415516
,
ENSP00000492269
,
ENSG00000184937
PRO
P19544
Pharos - Targets
P19544
Orphanet
15731
PDB
4R2S
,
3MYJ
,
4R2E
,
5KL6
,
6WLH
,
2JP9
,
5KL2
,
6B0P
,
2PRT
,
6BLW
,
4R2P
,
4WUU
,
6RSY
,
5KL3
,
5KL7
,
6B0Q
,
3HPJ
,
5KL4
,
2JPA
,
4R2Q
,
6B0O
,
7BBG
,
6B0R
,
1XF7
,
4R2R
,
5KL5
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.668
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.666
4
UniProt:Q6N021 TET2
1
TET2 [nucleoplasm]
(R-HSA-5221011)
0.602
9
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
IntAct:EBI-10171679 386682
0.488
2
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