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POU5F1 [nucleoplasm]
Stable Identifier
R-HSA-452472
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
OCT4 (POU5F1), POU domain, class 5, transcription factor 1, PO5F1_HUMAN, OCT3, OCT4
Icon
Locations in the PathwayBrowser for interactor UniProt:O00308
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Germ layer formation at gastrulation (Homo sapiens)
Expression of TBXT (T, Brachyury) in the primitive streak (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
Specification of the neural plate border (Homo sapiens)
POU5F1 and SOX2 bind the ZIC1 gene (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
TFAP2A:TFAP2C, POU5F1, SOX2 and MYB bind the PAX7 gene (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (Homo sapiens)
POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
Translation of OCT4 mRNA (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Specification of primordial germ cells (Homo sapiens)
Expression of POU5F1 (OCT4) in primordial germ cells (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01860 POU5F1 (OCT4)
Gene Names
POU5F1 (OCT4), POU5F1, OCT3, OCT4, OTF3
Chain
chain:1-360
Reference Genes
BioGPS Gene:5460 POU5F1 (OCT4)
CTD Gene:5460 POU5F1 (OCT4)
dbSNP Gene:5460 POU5F1 (OCT4)
ENSEMBL:ENSG00000204531 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000204531.21 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000206454.12 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000229094.9 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000230336.9 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000233911.9 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000235068.9 POU5F1 (OCT4)
ENSEMBL_homo_sapiens_GENE:ENSG00000237582.10 POU5F1 (OCT4)
HGNC:9221 POU5F1 (OCT4)
KEGG Gene (Homo sapiens):5460 POU5F1 (OCT4)
Monarch:5460 POU5F1 (OCT4)
NCBI Gene:5460 POU5F1 (OCT4)
OMIM:164177 POU5F1 (OCT4)
UCSC:Q01860 POU5F1 (OCT4)
Reference Transcript
RefSeq:NM_002701.5 POU5F1 (OCT4)
RefSeq:NM_001285987.1 POU5F1 (OCT4)
Other Identifiers
11736314_x_at
11755599_x_at
17028984
17031762
17034217
17036467
17039262
17041763
208286_3p_x_at
208286_PM_x_at
208286_x_at
210265_3p_x_at
210265_x_at
210905_3p_x_at
210905_PM_x_at
210905_x_at
214532_3p_x_at
214532_PM_x_at
214532_x_at
2360940
2360944
2360945
2360947
2948864
2948865
2948866
2948868
2948869
2948870
2948871
2948872
2948873
2948874
2948875
2948876
3115423
3115424
3115428
3115430
3115431
3115432
3115433
3115434
3115435
3442969
3442970
3442971
3442973
3442974
3442976
39626_s_at
5460
8124889
8178470
8179719
A_23_P59138
A_24_P144601
A_24_P214841
GE60351
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001227
GO:0001714
GO:0001824
GO:0003129
GO:0003133
GO:0003677
GO:0003700
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0009611
GO:0009653
GO:0009786
GO:0010468
GO:0010628
GO:0010629
GO:0019955
GO:0023052
GO:0030154
GO:0030509
GO:0031625
GO:0035019
GO:0035198
GO:0043226
GO:0043565
GO:0045944
GO:0048856
GO:0060795
GO:0060913
GO:0061629
GO:0090263
GO:0090308
GO:0140110
GO:1902894
GO:1990837
HMNXSV003019153
HMNXSV003025630
Hs.2860.3.S1_3p_a_at
Hs.2860.3.S1_3p_x_at
ILMN_1665632
ILMN_1679060
ILMN_1705546
ILMN_2068499
PH_hs_0013213
PH_hs_0032318
TC06001521.hg
TC06003584.hg
TC6_cox_hap2000153.hg
TC6_dbb_hap3000142.hg
TC6_mann_hap4000130.hg
TC6_mcf_hap5000130.hg
TC6_qbl_hap6000143.hg
TC6_ssto_hap7000125.hg
Z11899_s_at
g12382245_3p_a_at
g12382245_3p_x_at
g12382251_3p_a_at
g12382251_3p_x_at
g4505966_3p_a_at
g4505966_3p_at
g4505966_3p_x_at
Participates
as a component of
POU5F1:SOX2:NANOG:DPPA4 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:FOXD3 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:SALL1 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:CDX2 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:DKK1 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:HHEX gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:TSC22D1 gene [nucleoplasm] (Homo sapiens)
POU5F1:NANOG:GATA6 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:TDGF1 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:CTNNB1:TBPL2:FOXH1:SMAD3:POU5F1:NANOG:EOMES gene [nucleoplasm] (Homo sapiens)
FOXH1:SMAD3:POU5F1:NANOG:SOX2:EOMES gene [nucleoplasm] (Homo sapiens)
TFAP2A:TFAP2C:POU5F1:SOX2:MYB:PAX7 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:ZIC1 gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:GSC gene [nucleoplasm] (Homo sapiens)
POU5F1:SOX2 gene [nucleoplasm] (Homo sapiens)
POU5F1:STAT3:SALL4 gene [nucleoplasm] (Homo sapiens)
as an input of
POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)
POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)
POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)
TFAP2A:TFAP2C, POU5F1, SOX2 and MYB bind the PAX7 gene (Homo sapiens)
POU5F1 and SOX2 bind the ZIC1 gene (Homo sapiens)
POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)
as an output of
Expression of POU5F1 (OCT4) in primordial germ cells (Homo sapiens)
Translation of OCT4 mRNA (Homo sapiens)
This entity regulates
Negatively
Expression of TBXT (T, Brachyury) in the primitive streak
(Homo sapiens)
Inferred To
vvl [nucleoplasm]
(Drosophila melanogaster)
Pou5f1 [nucleoplasm]
(Rattus norvegicus)
POU5F1 [nucleoplasm]
(Bos taurus)
POU5F1 [nucleoplasm]
(Gallus gallus)
POU5F1 [nucleoplasm]
(Mus musculus)
POU5F1 [nucleoplasm]
(Sus scrofa)
ceh-6 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of POU5F1 [nucleoplasm]
(Drosophila melanogaster)
pdm2 [nucleoplasm]
(Drosophila melanogaster)
LOC481709 [nucleoplasm]
(Canis familiaris)
pou3f4 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001272916.1
,
NP_002692.2
HPA
ENSG00000204531-POU5F1
GeneCards
Q01860
Ensembl
ENST00000434616
,
ENST00000433348
,
ENSP00000373016
,
ENSP00000412665
,
ENST00000437747
,
ENST00000383524
,
ENSP00000400047
,
ENST00000429603
,
ENST00000376243
,
ENSG00000229094
,
ENST00000412166
,
ENST00000433063
,
ENSP00000387646
,
ENSG00000235068
,
ENSP00000365419
,
ENST00000454714
,
ENSG00000230336
,
ENSP00000405041
,
ENST00000419095
,
ENSG00000237582
,
ENSG00000206454
,
ENST00000429314
,
ENSP00000388842
,
ENSP00000259915
,
ENSP00000391681
,
ENSP00000392877
,
ENSG00000204531
,
ENST00000451077
,
ENSG00000233911
,
ENST00000259915
,
ENSP00000387619
,
ENSP00000391507
,
ENSP00000413622
PRO
Q01860
Pharos - Targets
Q01860
PDB
8SPU
,
7U0G
,
8OTS
,
8G8B
,
7U0I
,
8G8G
,
8G8E
,
6T90
,
8G87
,
6YOV
,
8G88
,
8SPS
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.645
4
UniProt:P63158
5
HMGB1 [secretory granule lumen]
(R-MMU-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-MMU-6803291)
HMGB1 [extracellular region]
(R-MMU-879382)
HMGB1 [nucleoplasm]
(R-MMU-266221)
HC23,45-HMGB1 [extracellular region]
(R-MMU-6797422)
0.591
3
IntAct:EBI-6901205 SOX2
0.564
3
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.564
2
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P03259 E1A
0.524
2
UniProt:Q8JSK4 Q8JSK4
0.524
2
UniProt:NANOG ENSG00000111704
0.524
2
UniProt:Q9UJU5 FOXD3
1
FOXD3 [nucleoplasm]
(R-HSA-452918)
0.524
2
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.499
3
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.462
2
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