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POU5F1 [nucleoplasm]
Stable Identifier
R-HSA-452472
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
OCT4 (POU5F1), POU domain, class 5, transcription factor 1, PO5F1_HUMAN, OCT3, OCT4
Icon
Locations in the PathwayBrowser for interactor UniProt:P48431 SOX2
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation (Homo sapiens)
POU5F1 (OCT4), NANOG bind the CDX2 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), NANOG bind the GATA6 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
Translation of OCT4 mRNA (Homo sapiens)
POU5F1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01860 POU5F1
Gene Names
POU5F1, OCT3, OCT4, OTF3
Chain
chain:1-360
Reference Genes
BioGPS Gene:5460 POU5F1
COSMIC (genes):POU5F1 POU5F1
CTD Gene:5460 POU5F1
dbSNP Gene:5460 POU5F1
ENSEMBL:ENSG00000204531 POU5F1 (OCT4)
ENSEMBL:ENSG00000206454 POU5F1
ENSEMBL:ENSG00000229094 POU5F1
ENSEMBL:ENSG00000230336 POU5F1
ENSEMBL:ENSG00000233911 POU5F1
ENSEMBL:ENSG00000235068 POU5F1
ENSEMBL:ENSG00000237582 POU5F1
HGNC:9221 POU5F1
KEGG Gene (Homo sapiens):5460 POU5F1
Monarch:5460 POU5F1
NCBI Gene:5460 POU5F1
OMIM:164177 POU5F1
UCSC:Q01860 POU5F1
Reference Transcript
RefSeq:NM_001285987.1 POU5F1
RefSeq:NM_002701.5 POU5F1
Other Identifiers
0003290711
0007000458
0106760440
11736314_x_at
11755599_x_at
17028984
17031762
17034217
17036467
17039262
17041763
208286_3p_x_at
208286_x_at
210265_3p_x_at
210265_x_at
210905_3p_x_at
210905_x_at
214532_3p_x_at
214532_x_at
2360940
2360944
2360945
2360947
2948864
2948865
2948866
2948868
2948869
2948870
2948871
2948872
2948873
2948874
2948875
2948876
3115423
3115424
3115428
3115430
3115431
3115432
3115433
3115434
3115435
3442969
3442970
3442971
3442973
3442974
3442976
39626_s_at
5460
8124889
8178470
8179719
A_23_P59138
A_24_P144601
A_24_P214841
GE60351
GO:0000122
GO:0000228
GO:0000790
GO:0000976
GO:0000981
GO:0000987
GO:0001227
GO:0001228
GO:0001714
GO:0001824
GO:0003674
GO:0003677
GO:0003700
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006355
GO:0006357
GO:0006950
GO:0007275
GO:0008150
GO:0009058
GO:0009611
GO:0009653
GO:0009786
GO:0009790
GO:0010468
GO:0010628
GO:0010629
GO:0019899
GO:0019955
GO:0030154
GO:0031625
GO:0034641
GO:0035019
GO:0035198
GO:0043226
GO:0043565
GO:0045944
GO:0048646
GO:0048856
GO:0051301
GO:0060965
GO:1902894
GO:1990837
Hs.2860.3.S1_3p_a_at
Hs.2860.3.S1_3p_x_at
ILMN_1665632
ILMN_1679060
ILMN_1705546
ILMN_2068499
PH_hs_0013213
PH_hs_0032318
TC06001521.hg
TC06003584.hg
TC6_cox_hap2000153.hg
TC6_dbb_hap3000142.hg
TC6_mann_hap4000130.hg
TC6_mcf_hap5000130.hg
TC6_qbl_hap6000143.hg
TC6_ssto_hap7000125.hg
Z11899_s_at
g12382245_3p_a_at
g12382245_3p_x_at
g12382251_3p_a_at
g12382251_3p_x_at
g4505966_3p_a_at
g4505966_3p_at
g4505966_3p_x_at
Participant Of
hasComponent
POU5F1:NANOG:GATA6 gene [nucleoplasm]
POU5F1:SOX2:NANOG:CDX2 gene [nucleoplasm]
POU5F1:SOX2:NANOG:DKK1 gene [nucleoplasm]
POU5F1:SOX2:NANOG:DPPA4 gene [nucleoplasm]
POU5F1:SOX2:NANOG:EOMES gene [nucleoplasm]
POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm]
POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm]
POU5F1:SOX2:NANOG:FOXD3 gene [nucleoplasm]
POU5F1:SOX2:NANOG:GSC gene [nucleoplasm]
POU5F1:SOX2:NANOG:HHEX gene [nucleoplasm]
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]
POU5F1:SOX2:NANOG:SALL1 gene [nucleoplasm]
POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm]
POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm]
POU5F1:SOX2:NANOG:TDGF1 gene [nucleoplasm]
POU5F1:SOX2:NANOG:TSC22D1 gene [nucleoplasm]
POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]
POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]
POU5F1:STAT3:SALL4 gene [nucleoplasm]
input
POU5F1 (OCT4), NANOG bind the CDX2 promoter
POU5F1 (OCT4), NANOG bind the GATA6 promoter
POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene
POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter
POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter
POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter
POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter
POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter
POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter
POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter
POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter
POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter
POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter
POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter
POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter
POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter
POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter
POU5F1 (OCT4), STAT3 bind the SALL4 promoter
output
Translation of OCT4 mRNA
Inferred To
NPDC1 [nucleoplasm] (Gallus gallus)
Pou5f1 [nucleoplasm] (Mus musculus)
Pou5f1 [nucleoplasm] (Rattus norvegicus)
pou3f3b [nucleoplasm] (Danio rerio)
POU5F1 [nucleoplasm] (Bos taurus)
POU5F1 [nucleoplasm] (Canis familiaris)
POU5F1 [nucleoplasm] (Gallus gallus)
POU5F1 [nucleoplasm] (Sus scrofa)
POU5F1 [nucleoplasm] (Xenopus tropicalis)
ceh-6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of POU5F1 [nucleoplasm] (Bos taurus)
Homologues of POU5F1 [nucleoplasm] (Danio rerio)
Homologues of POU5F1 [nucleoplasm] (Gallus gallus)
pou5f1 [nucleoplasm] (Danio rerio)
pou3f3a [nucleoplasm] (Danio rerio)
Cross References
RefSeq
NP_001272916.1
,
NP_002692.2
OpenTargets
ENSG00000204531
GeneCards
Q01860
HPA
ENSG00000204531-POU5F1
Ensembl
ENST00000376243
,
ENST00000259915
,
ENSG00000229094
,
ENSP00000365419
,
ENSG00000235068
,
ENST00000419095
,
ENSG00000230336
,
ENSP00000405041
,
ENST00000454714
,
ENST00000433063
,
ENSP00000388842
,
ENSG00000206454
,
ENSP00000387646
,
ENST00000383524
,
ENSP00000400047
,
ENST00000437747
,
ENST00000412166
,
ENSP00000373016
,
ENST00000429603
,
ENST00000433348
,
ENST00000451077
,
ENST00000434616
,
ENSP00000392877
,
ENSP00000412665
,
ENST00000429314
,
ENSG00000237582
,
ENSP00000387619
,
ENSP00000391507
,
ENSP00000413622
,
ENSP00000391681
,
ENSG00000233911
,
ENSG00000204531
,
ENSP00000259915
PRO
Q01860
PDB
6T90
,
6YOV
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.645
4
UniProt:P63158
5
Hmgb1 [ficolin-1-rich granule lumen]
(R-MMU-6803291)
Hmgb1 [extracellular region]
(R-MMU-6797422)
Hmgb1 [secretory granule lumen]
(R-MMU-6803337)
Hmgb1 [nucleoplasm]
(R-MMU-266221)
Hmgb1 [extracellular region]
(R-MMU-879382)
0.591
3
IntAct:EBI-6901205 SOX2
0.564
3
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.564
2
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P03259 E1A
0.524
2
UniProt:Q8JSK4 Q8JSK4
0.524
2
UniProt:NANOG ENSG00000111704
0.524
2
UniProt:Q9UJU5 FOXD3
1
FOXD3 [nucleoplasm]
(R-HSA-452918)
0.524
2
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.499
3
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.462
2
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