Expression of STAT3

Stable Identifier
R-HSA-452515
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of STAT3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The STAT3 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. STAT3 is expressed in embryonic stem cells (Schuringa et al. 2002, Fong et al. 2008). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the STAT3 gene and enhance transcription (Boyer et al. 2005, Greber et al. 2007, Fong et al. 2008). The binding site of POU5F1 is adjacent to the binding site of SOX2 in the STAT3 promoter (Boyer et al. 2005). Signaling by LIF via STAT3 in murine but not human stem cells is sufficient to prevent differentiation (Schuringa et al. 2002, Humphrey et al. 2004, Daheron et al. 2004).
Literature References
PubMed ID Title Journal Year
15342941 LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells

Dahéron, L, Opitz, SL, Zaehres, H, Lensch, MW, Lensch, WM, Andrews, PW, Itskovitz-Eldor, J, Daley, GQ

Stem Cells 2004
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Greber, B, Lehrach, H, Adjaye, J

BMC Dev. Biol. 2007
18388306 Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

Fong, H, Hohenstein, KA, Donovan, PJ

Stem Cells 2008
15277698 Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

Humphrey, RK, Beattie, GM, Lopez, AD, Bucay, N, King, CC, Firpo, MT, Rose-John, S, Hayek, A

Stem Cells 2004
11855863 LIF-induced STAT3 signaling in murine versus human embryonal carcinoma (EC) cells

Schuringa, JJ, van der Schaaf, S, Vellenga, E, Eggen, BJ, Kruijer, W

Exp Cell Res 2002
7545930 Stat3 and Stat4: members of the family of signal transducers and activators of transcription

Zhong, Z, Wen, Z, Darnell JE, Jr

Proc Natl Acad Sci U S A 1994
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm] (Homo sapiens)
Active Unit
NANOG [nucleoplasm]
POU5F1 [nucleoplasm]
SOX2 [nucleoplasm]
Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-01-16)
Cite Us!