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PBX1 [nucleoplasm]
Stable Identifier
R-HSA-453045
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pre-B-cell leukemia transcription factor 1, PBX1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q96GN5 CDA7L
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
PBX1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)
PBX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40424 PBX1
Gene Names
PBX1, PRL
Chain
chain:1-430
Reference Genes
BioGPS Gene:5087 PBX1
COSMIC (genes):PBX1 PBX1
COSMIC (genes):PRL PBX1
CTD Gene:5087 PBX1
dbSNP Gene:5087 PBX1
ENSEMBL:ENSG00000185630 PBX1
HGNC:8632 PBX1
KEGG:hsa:5087 PBX1
Monarch:5087 PBX1
NCBI Gene:5087 PBX1
OMIM:176310 PBX1
UCSC:P40424 PBX1
Reference Transcript
RefSeq:NM_002585.3 PBX1
RefSeq:NM_001204963.1 PBX1
RefSeq:XM_005245229.3 PBX1
Other Identifiers
11719412_at
11719413_a_at
11719414_a_at
11749792_a_at
11752626_a_at
11757871_s_at
11758070_s_at
11761679_at
16673191
16673229
16673231
205253_PM_at
205253_at
212148_PM_at
212148_at
212151_PM_at
212151_at
2364673
2364674
2364679
2364680
2364681
2364682
2364683
2364684
2364685
2364686
2364687
2364688
2364691
2364692
2364704
2364712
2364713
2364722
2364725
2364726
2364755
2364756
2364757
2364758
2364759
2364760
2364761
2364762
2364766
2364770
2364771
2364772
2364773
2364774
2364777
2364796
2364797
2364798
2364799
2364800
2364801
2364802
2364803
2364804
2364805
2364815
2364816
2364817
2364818
2364844
2364845
2364874
32063_at
33355_at
46516_r_at
5087
69620_at
7906954
84235_at
A_14_P108826
A_14_P118233
A_14_P119839
A_14_P135647
A_23_P62953
A_24_P173823
A_24_P247849
A_33_P3255664
GE56167
GE58116
GE86181
GO:0000086
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001221
GO:0001222
GO:0001228
GO:0001654
GO:0001655
GO:0001658
GO:0001779
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0006355
GO:0006357
GO:0006629
GO:0006694
GO:0007420
GO:0007548
GO:0008283
GO:0009887
GO:0009952
GO:0009954
GO:0010971
GO:0022414
GO:0030154
GO:0030278
GO:0030325
GO:0030326
GO:0035162
GO:0042127
GO:0043226
GO:0043433
GO:0043565
GO:0045665
GO:0045944
GO:0048536
GO:0048538
GO:0048568
GO:0048666
GO:0048706
GO:0048856
GO:0072089
GO:0090575
GO:0140110
GO:0140297
GO:1990837
GO:2000648
HMNXSV003015884
HMNXSV003038644
Hs.21851.0.S1_3p_at
Hs.21851.0.S2_3p_at
ILMN_1784678
M86546_at
PH_hs_0001170
PH_hs_0024735
TC01001437.hg
TC01004809.hg
g4505622_3p_at
Participates
as a component of
PBX1:PKNOX1,MEIS1 [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:MEIS1,PKNOX1 [nucleoplasm] (Homo sapiens)
PBX1:PKNOX1 [nucleoplasm] (Homo sapiens)
HOXB1:PBX1:PKNOX1 [nucleoplasm] (Homo sapiens)
POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm] (Homo sapiens)
as an output of
PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)
as an input of
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter (Homo sapiens)
Inferred To
PBX1 [nucleoplasm]
(Bos taurus)
PBX1 [nucleoplasm]
(Canis familiaris)
PBX1 [nucleoplasm]
(Sus scrofa)
Pbx1 [nucleoplasm]
(Mus musculus)
Pbx1 [nucleoplasm]
(Rattus norvegicus)
PBX1A [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_002576.1
,
NP_001191892.1
,
XP_005245286.1
OpenTargets
ENSG00000185630
ENSEMBL
ENST00000420696
,
ENST00000699845
,
ENSP00000356872
,
ENST00000367897
,
ENST00000627490
,
ENSP00000485692
,
ENSP00000514643
,
ENSP00000405890
HPA
ENSG00000185630-PBX1
PRO
P40424
Pharos - Targets
P40424
Orphanet
PBX1
PDB
1B72
,
1PUF
HMDB Protein
HMDBP08155
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55347 PKNOX1
1
PKNOX1 [nucleoplasm]
(R-HSA-5617496)
0.814
12
UniProt:Q12948 FOXC1
1
FOXC1 [nucleoplasm]
(R-HSA-3927815)
0.702
5
UniProt:O14770-4 MEIS2
0.675
9
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.556
3
UniProt:P31273 HOXC8
1
HOXC8 [nucleoplasm]
(R-HSA-3222311)
0.556
3
UniProt:Q86YD7 F90A1
0.556
3
UniProt:Q96GN5 CDA7L
0.556
3
UniProt:Q00444 HXC5
0.556
3
UniProt:Q5PSV4 BRM1L
0.556
3
UniProt:Q5JVL4 EFHC1
0.556
3
UniProt:P09067 HXB5
0.556
3
UniProt:O00470 MEIS1
1
MEIS1 [nucleoplasm]
(R-HSA-5490327)
0.547
3
UniProt:O14770 MEIS2
0.547
3
UniProt:Q96KN3 PKNX2
0.547
3
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