Phosphorylated SHC recruits GRB2:SOS1

Stable Identifier
R-HSA-453111
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Shc is tyrosine phosphorylated by an unidentified kinase, creating a docking site for the SH2 domain of Grb2 (Zhu et al. 1994). Grb2 is an adaptor protein believed to be constitutively associated with the guanine nucleotide exchange protein Sos1 (often abbreviated to Sos). Recruitment of the Grb2:Sos1 complex leads to activation of the Ras pathway (Ravichandran & Burakoff 1994) and consequently activation of the MAPK pathway.

Literature References
PubMed ID Title Journal Year
1465135 Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Rozakis-Adcock, M, McGlade, J, Mbamalu, G, Pelicci, G, Daly, R, Li, W, Batzer, A, Thomas, S, Brugge, J, Pelicci, PG

Nature 1992
8294403 The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation

Ravichandran, KS, Burakoff, SJ

J Biol Chem 1994
Participants
Participant Of
Orthologous Events
Authored
Reviewed