Mitotic G2-G2/M phases

Stable Identifier
R-HSA-453274
Type
Pathway
Species
Homo sapiens
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Summation

Mitotic G2 (gap 2) phase is the second growth phase during eukaryotic mitotic cell cycle. G2 encompasses the interval between the completion of DNA synthesis and the beginning of mitosis. During G2, the cytoplasmic content of the cell increases. At G2/M transition, duplicated centrosomes mature and separate and CDK1:cyclin B complexes become active, setting the stage for spindle assembly and chromosome condensation that occur in the prophase of mitosis (O'Farrell 2001, Bruinsma et al. 2012, Jiang et al. 2014).

Literature References
PubMed ID Title Journal Year
25128564 The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle

Wang, G, Jiang, Q, Zhang, C

J. Cell. Sci. 2014
11719058 Triggering the all-or-nothing switch into mitosis

O'Farrell, PH

Trends Cell Biol. 2001
23141205 Switching Polo-like kinase-1 on and off in time and space

Bruinsma, W, Raaijmakers, JA, Medema, RH

Trends Biochem. Sci. 2012
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