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SUMO2-K119,K194-NR5A1 [nucleoplasm]
Stable Identifier
R-HSA-4546383
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Steroidogenic factor 1, STF1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q53TS8 C2CD6
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)
SUMO2-K119,K194-NR5A1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13285 NR5A1
Gene Names
NR5A1, AD4BP, FTZF1, SF1
Chain
chain:1-461
Reference Genes
BioGPS Gene:2516 NR5A1
COSMIC (genes):NR5A1 NR5A1
CTD Gene:2516 NR5A1
dbSNP Gene:2516 NR5A1
ENSEMBL:ENSG00000136931 NR5A1
HGNC:7983 NR5A1
KEGG Gene (Homo sapiens):2516 NR5A1
Monarch:2516 NR5A1
NCBI Gene:2516 NR5A1
OMIM:184757 NR5A1
UCSC:Q13285 NR5A1
Reference Transcript
RefSeq:NM_004959.4 NR5A1
RefSeq:XM_011518455.2 NR5A1
RefSeq:XM_005251871.3 NR5A1
Other Identifiers
0005050685
11731105_at
11731106_at
17098293
210333_at
2516
3225059
3225060
3225061
3225070
3225075
3225076
3225077
3225078
3225089
3225090
32447_at
8164077
83680_at
83682_g_at
A_23_P216915
D88155_s_at
GE546293
GO:0000003
GO:0000228
GO:0000790
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001553
GO:0003674
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005543
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006355
GO:0006357
GO:0006366
GO:0006367
GO:0006629
GO:0007165
GO:0007530
GO:0007538
GO:0007568
GO:0008150
GO:0008270
GO:0008289
GO:0008584
GO:0008585
GO:0009058
GO:0009755
GO:0009888
GO:0010259
GO:0010628
GO:0019899
GO:0022414
GO:0030154
GO:0030238
GO:0030325
GO:0030522
GO:0032991
GO:0034641
GO:0042025
GO:0042445
GO:0043167
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0050810
GO:0051457
GO:0090575
GO:0097210
GO:0097720
GO:1990837
GO:2000020
GO:2000195
ILMN_1799675
ILMN_1815320
PH_hs_0009492
TC09001579.hg
U76388_at
g2052387_3p_at
g2052387_3p_x_at
Participant Of
output
PIAS1,3 SUMOylates NR5A1 with SUMO2
Other forms of this molecule
SUMO1-K119,K194-NR5A1 [nucleoplasm]
NR5A1 [nucleoplasm]
Inferred To
Nr5a1 [nucleoplasm] (Mus musculus)
Nr5a1 [nucleoplasm] (Rattus norvegicus)
nr5a1 [nucleoplasm] (Xenopus tropicalis)
Homologues of SUMO2-K119,K194-NR5A1 [nucleoplasm] (Danio rerio)
Homologues of SUMO2-K119,K194-NR5A1 [nucleoplasm] (Drosophila melanogaster)
nr5a5 [nucleoplasm] (Danio rerio)
nr5a2 [nucleoplasm] (Danio rerio)
NR5A1 [nucleoplasm] (Bos taurus)
NR5A1 [nucleoplasm] (Canis familiaris)
NR5A1 [nucleoplasm] (Gallus gallus)
ftz-f1 [nucleoplasm] (Drosophila melanogaster)
nr5a1a [nucleoplasm] (Danio rerio)
nr5a1b [nucleoplasm] (Danio rerio)
Hr39 [nucleoplasm] (Drosophila melanogaster)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 119
Coordinate
119
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 194
Coordinate
194
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
XP_005251928.1
,
XP_011516757.1
,
NP_004950.2
OpenTargets
ENSG00000136931
GeneCards
Q13285
ZINC - Substances
STF1_HUMAN
HPA
ENSG00000136931-NR5A1
ZINC target
Q13285
Ensembl
ENSG00000136931
,
ENSP00000362690
,
ENST00000373588
PRO
Q13285
Orphanet
17744
ZINC - Predictions - Purchasable
STF1_HUMAN
HMDB Protein
HMDBP02951
PDB
1YOW
,
4QJR
,
1ZDT
,
4QK4
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51843 NR0B1
0.805
9
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:Q53TS8 C2CD6
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.556
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.556
3
UniProt:Q9NPJ4 PNRC2
1
PNRC2 [cytosol]
(R-HSA-8879146)
0.488
2
IntAct:EBI-9981598 3BHS2
0.462
2
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