Reactome | Ack-HIST1H2AG [nucleoplasm]

Ack-HIST1H2AG [nucleoplasm]

Stable Identifier

R-HSA-4551311

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - HCMV Infection (Homo sapiens)
    - HCMV Early Events (Homo sapiens)
      - Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
      - Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)
    - HCMV Late Events (Homo sapiens)
      - Late (L) Gene Expression (Human cytomegalovirus)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK-histone H2A [nucleoplasm] (Homo sapiens)
        
        AcK-histone HIST1H2A [nucleoplasm] (Homo sapiens)
        
        Ack-HIST1H2AG [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C0S8 H2AC11

Gene Names

H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM

Chain

initiator methionine:1, chain:2-130

Reference Genes

BioGPS Gene:8329 H2AC11

BioGPS Gene:8330 H2AC11

BioGPS Gene:8332 H2AC11

BioGPS Gene:8336 H2AC11

BioGPS Gene:8969 H2AC11

CTD Gene:8329 H2AC11

CTD Gene:8330 H2AC11

CTD Gene:8332 H2AC11

CTD Gene:8336 H2AC11

CTD Gene:8969 H2AC11

dbSNP Gene:8329 H2AC11

dbSNP Gene:8330 H2AC11

dbSNP Gene:8332 H2AC11

dbSNP Gene:8336 H2AC11

dbSNP Gene:8969 H2AC11

ENSEMBL:ENSG00000196747 HIST1H2AI

ENSEMBL:ENSG00000196787 HIST1H2AG

ENSEMBL:ENSG00000275221 HIST1H2AK

ENSEMBL:ENSG00000276903 HIST1H2AL

ENSEMBL:ENSG00000278677 HIST1H2AM

HGNC:4725 H2AC11

HGNC:4726 H2AC11

HGNC:4730 H2AC11

HGNC:4735 H2AC11

HGNC:4737 H2AC11

KEGG Gene (Homo sapiens):8329 H2AC11

KEGG Gene (Homo sapiens):8330 H2AC11

KEGG Gene (Homo sapiens):8332 H2AC11

KEGG Gene (Homo sapiens):8336 H2AC11

KEGG Gene (Homo sapiens):8969 H2AC11

Monarch:8329 H2AC11

Monarch:8330 H2AC11

Monarch:8332 H2AC11

Monarch:8336 H2AC11

Monarch:8969 H2AC11

NCBI Gene:8329 H2AC11

NCBI Gene:8330 H2AC11

NCBI Gene:8332 H2AC11

NCBI Gene:8336 H2AC11

NCBI Gene:8969 H2AC11

OMIM:602787 H2AC11

OMIM:602788 H2AC11

OMIM:602793 H2AC11

OMIM:602796 H2AC11

OMIM:615012 H2AC11

UCSC:P0C0S8 H2AC11

Reference Transcript

Other Identifiers

0001240113

0001940154

0003450239

0005080484

0005340519

11715162_s_at

11715219_s_at

11734234_at

11737572_x_at

11740124_at

11740125_x_at

11759131_at

11759220_at

11759248_at

17005787

17005858

17005876

17016496

17016512

207156_at

208583_x_at

214542_x_at

214554_at

284_at

285_g_at

2899757

2899758

2899759

2899760

2899761

2899762

2899763

2899764

2899765

2899767

2900048

2900094

2900095

2900096

2947042

2947043

2947044

2947045

2947065

2947066

2947103

2947104

2947105

31749_f_at

31768_at

33023_at

34156_i_at

34157_f_at

8117535

8117580

8117608

8124524

8124540

8329

8330

8332

8336

8969

ADDON002309.hg

ADDON002495.hg

ADDON002786.hg

ADDON002787.hg

ADDON002823.hg

A_14_P122277

A_14_P122573

A_14_P200168

A_14_P200169

A_21_P0000197

A_23_P168014

A_23_P363174

A_24_P217848

A_24_P303354

A_24_P394510

A_24_P414658

A_24_P86389

A_32_P221799

A_33_P3360216

GE535482

GE57662

GE81292

GE81293

GE81294

GO:0000228

GO:0000786

GO:0000790

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005694

GO:0006325

GO:0006342

GO:0008150

GO:0009058

GO:0019899

GO:0032991

GO:0034641

GO:0043226

GO:0046982

GO:0051276

GO:0070062

Hs.137592.0.S1_3p_at

Hs.137592.0.S1_3p_x_at

Hs.233568.0.S1_3p_at

ILMN_1663453

ILMN_1686478

ILMN_1694699

ILMN_1756022

ILMN_1789512

ILMN_2184602

ILMN_3246993

L19778_at

PH_hs_0007861

PH_hs_0028903

PH_hs_0031765

PH_hs_0037184

TC06000223.hg

TC06000269.hg

TC06001425.hg

TC06001430.hg

TC06004063.hg

Z83742_at

g10800131_3p_at

Participant Of

hasMember

AcK-histone HIST1H2A [nucleoplasm]

Other forms of this molecule

K63polyUb-HIST1H2AG [nucleoplasm]

Ub-HIST1H2AG [nucleoplasm]

Ack6-HIST1H2AG [nucleoplasm]

Me2aR30-HIST1H2AG [nucleoplasm]

MeR30-HIST1H2AG [nucleoplasm]

Me2aR4-HIST1H2AG [nucleoplasm]

MeR4-HIST1H2AG [nucleoplasm]

Me2aR12-HIST1H2AG [nucleoplasm]

MeR12-HIST1H2AG [nucleoplasm]

HIST1H2AG [nucleoplasm]

Inferred To

hta2 [nucleoplasm] (Schizosaccharomyces pombe)

mpped1 [nucleoplasm] (Xenopus tropicalis)

hist1h2ah [nucleoplasm] (Xenopus tropicalis)

hist1h2ad [nucleoplasm] (Xenopus tropicalis)

Ack-HIST1H2AB [nucleoplasm] (Plasmodium falciparum)

Ack-HIST1H2AB [nucleoplasm] (Xenopus tropicalis)

HTA1 [nucleoplasm] (Saccharomyces cerevisiae)

HTA2 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of Ack-HIST1H2AG [nucleoplasm] (Xenopus tropicalis)

LOC100492813 [nucleoplasm] (Xenopus tropicalis)

H2Av2 [nucleoplasm] (Dictyostelium discoideum)

h2ax [nucleoplasm] (Danio rerio)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of Ack-HIST1H2AB [nucleoplasm] (Schizosaccharomyces pombe)

hist2h2ab [nucleoplasm] (Xenopus tropicalis)

slc25a43 [nucleoplasm] (Xenopus tropicalis)

H2AX [nucleoplasm] (Dictyostelium discoideum)

H2Av3 [nucleoplasm] (Dictyostelium discoideum)

htas-1 [nucleoplasm] (Caenorhabditis elegans)

H2Av1 [nucleoplasm] (Dictyostelium discoideum)

hta1 [nucleoplasm] (Schizosaccharomyces pombe)

h2afx [nucleoplasm] (Xenopus tropicalis)

ppard [nucleoplasm] (Xenopus tropicalis)

HIST1H2AH [nucleoplasm] (Sus scrofa)

H2AC14 [nucleoplasm] (Canis familiaris)

Modified Residues

Name

N6-acetyl-L-lysine at unknown position

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_003501.1, NP_066408.1, NP_003500.1, NP_003502.1, NP_003505.1

OpenTargets

ENSG00000196787

GeneCards

P0C0S8

HPA

ENSG00000278677-HIST1H2AM, ENSG00000196787-HIST1H2AG, ENSG00000275221-HIST1H2AK, ENSG00000196747-HIST1H2AI, ENSG00000276903-HIST1H2AL

Ensembl

ENSG00000196787, ENSG00000196747, ENSP00000352627, ENSP00000352119, ENSP00000351589, ENST00000359611, ENSP00000482431, ENSP00000482538, ENST00000358739, ENST00000613174, ENST00000618958, ENSG00000276903, ENST00000359193, ENSG00000278677, ENSG00000275221

PRO

P0C0S8

HMDB Protein

HMDBP07725

PDB

4QYL, 6R0C, 6RNY, 5KGF

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.672	21
UniProt:P84233 Histone H3.2	2	Histone H3.2 [nucleoplasm] (R-XLA-4549227) Ack15-histone H3.2 [nucleoplasm] (R-XLA-4549248)	0.65	14
UniProt:P0CG47 UBB	109	UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-110-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-186-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-182-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-106-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-180-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114) Ub-104-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783149) N6-glycyl-L-lysine-UBB(1-76) [cytosol] (R-HSA-8869049) N6-glycyl-L-lysine-UBB(153-228) [cytosol] (R-HSA-8869046) N6-glycyl-L-lysine-UBB(77-152) [cytosol] (R-HSA-8869047) adenylatedG152-UBB(77-152) [nucleoplasm] (R-HSA-8852094) adenylatedG228-UBB(153-228) [nucleoplasm] (R-HSA-8852104) adenylatedG76-UBB(1-76) [nucleoplasm] (R-HSA-8852101) UBB [cytosol] (R-HSA-8853516) adenylatedG76-UBB(1-76) [cytosol] (R-HSA-8852121) adenylatedG228-UBB(153-228) [cytosol] (R-HSA-8852049) adenylatedG152-UBB(77-152) [cytosol] (R-HSA-8852113) Ub-124-UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943100) Ub-48-UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943138) Ub-200-UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943117) UBB(153-228) [plasma membrane] (R-HSA-3149455) UBB(1-76) [plasma membrane] (R-HSA-3149453) UBB(77-152) [plasma membrane] (R-HSA-3149463) UBB(77-152) [endosome membrane] (R-HSA-939251) UBB(1-76) [endosome membrane] (R-HSA-939240) UBB(153-228) [endosome membrane] (R-HSA-939247) UBB(153-228) [endoplasmic reticulum membrane] (R-HSA-8943098) UBB(77-152) [endoplasmic reticulum membrane] (R-HSA-8943111) UBB(1-76) [endoplasmic reticulum membrane] (R-HSA-8943078) Ub-106-UBB(77-152) [cytosol] (R-HSA-5689191) Ub-182-UBB(153-228) [cytosol] (R-HSA-5689214) Ub-29-UBB(1-76) [cytosol] (R-HSA-5689207) Ub-158-UBB(153-228) [cytosol] (R-HSA-5689099) Ub-82-UBB(77-152) [cytosol] (R-HSA-5689080) Ub-6-UBB(1-76) [cytosol] (R-HSA-5689075) Ub-33-UBB(1-76) [cytosol] (R-HSA-5689198) Ub-186-UBB(153-228) [cytosol] (R-HSA-5689146) Ub-110-UBB(77-152) [cytosol] (R-HSA-5689203) Ub-27-UBB(1-76) [cytosol] (R-HSA-5689161) Ub-104-UBB(77-152) [cytosol] (R-HSA-5689139) Ub-180-UBB(153-228) [cytosol] (R-HSA-5689138) Ub-11-UBB(1-76) [cytosol] (R-HSA-3095929) Ub-163-UBB(153-228) [cytosol] (R-HSA-3095932) Ub-87-UBB(77-152) [cytosol] (R-HSA-3095917) Ub-139-UBB(77-152) [endosome membrane] (R-HSA-939217) Ub-215-UBB(153-228) [endosome membrane] (R-HSA-939193) Ub-63-UBB(1-76) [endosome membrane] (R-HSA-939167) Ub-139-UBB(77-152) [plasma membrane] (R-HSA-939867) Ub-63-UBB(1-76) [plasma membrane] (R-HSA-939872) Ub-215-UBB(153-228) [plasma membrane] (R-HSA-939852) Ub-27-UBB(1-76) [nucleoplasm] (R-HSA-6782673) Ub-180-UBB(153-228) [nucleoplasm] (R-HSA-6782604) Ub-104-UBB(77-152) [nucleoplasm] (R-HSA-6782627) Ub-106-UBB(77-152) [nucleoplasm] (R-HSA-6782652) Ub-182-UBB(153-228) [nucleoplasm] (R-HSA-6782665) Ub-29-UBB(1-76) [nucleoplasm] (R-HSA-6782595) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-6782527) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-6782505) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-6782478) Ub-11-UBB(1-76) [nucleoplasm] (R-HSA-6782649) Ub-87-UBB(77-152) [nucleoplasm] (R-HSA-6782607) Ub-163-UBB(153-228) [nucleoplasm] (R-HSA-6782598) Ub-186-UBB(153-228) [nucleoplasm] (R-HSA-6782655) Ub-110-UBB(77-152) [nucleoplasm] (R-HSA-6782591) Ub-33-UBB(1-76) [nucleoplasm] (R-HSA-6782601) Ub-82-UBB(77-152) [nucleoplasm] (R-HSA-6782683) Ub-6-UBB(1-76) [nucleoplasm] (R-HSA-6782600) Ub-158-UBB(153-228) [nucleoplasm] (R-HSA-6782639) UBB(77-152) [nucleoplasm] (R-HSA-939870) UBB(1-76) [nucleoplasm] (R-HSA-939847) UBB(153-228) [nucleoplasm] (R-HSA-939854) Ub-48-UBB(1-76) [nucleoplasm] (R-HSA-5683040) Ub-124-UBB(77-152) [nucleoplasm] (R-HSA-5683036) Ub-200-UBB(153-228) [nucleoplasm] (R-HSA-5683038) Ub-139-UBB(77-152) [nucleoplasm] (R-HSA-6782488) Ub-63-UBB(1-76) [nucleoplasm] (R-HSA-6782489) Ub-215-UBB(153-228) [nucleoplasm] (R-HSA-6782475) UBB(153-228) [late endosome lumen] (R-HSA-9660014) UBB(77-152) [late endosome lumen] (R-HSA-9660021) UBB(1-76) [late endosome lumen] (R-HSA-9660017) Ub-48-UBB(1-76) [cytosol] (R-HSA-939249) Ub-124-UBB(77-152) [cytosol] (R-HSA-939225) Ub-200-UBB(153-228) [cytosol] (R-HSA-939197) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213) UBB(1-76) [cytosol] (R-HSA-939214) UBB(77-152) [lysosomal lumen] (R-HSA-9660011) UBB(1-76) [lysosomal lumen] (R-HSA-9660024) UBB(153-228) [lysosomal lumen] (R-HSA-9660025) Ub-63-UBB(1-76) [cytosol] (R-HSA-939224) Ub-215-UBB(153-228) [cytosol] (R-HSA-939168) Ub-139-UBB(77-152) [cytosol] (R-HSA-939235)	0.65	14
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.527	2
UniProt:O95760 IL33	3	PolyUb-IL33 [nucleoplasm] (R-HSA-6783057) IL33 [extracellular region] (R-HSA-448567) IL33 [nucleoplasm] (R-HSA-6783145)	0.499	3

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