SUMOylation of RPA1 (RPA70) with SUMO2,3

Stable Identifier
R-HSA-4551616
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RPA1 (RPA70) is SUMOylated at lysine-449 and lysine-577 with SUMO2,3 (Dou et al. 2010, Tammsalu et al. 2014). SUMOylation of RPA1 recruits RAD51 to sites of DNA damage to initiate repair through homologous recombination.

Literature References
PubMed ID Title Journal Year
20705237 Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex

Dou, H, Huang, C, Singh, M, Carpenter, PB, Yeh, ET

Mol. Cell 2010
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed