Reactome: A Curated Pathway Database

SUMOylation of RPA1 (RPA70) with SUMO2,3

Stable Identifier
R-HSA-4551616
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RPA1 (RPA70) is SUMOylated at lysine-449 and lysine-577 with SUMO2,3 (Dou et al. 2010, Tammsalu et al. 2014). SUMOylation of RPA1 recruits RAD51 to sites of DNA damage to initiate repair through homologous recombination.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events