SUMOylation of RPA1 (RPA70) with SUMO2,3

Stable Identifier
R-HSA-4551616
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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RPA1 (RPA70) is SUMOylated at lysine-449 and lysine-577 with SUMO2,3 (Dou et al. 2010, Tammsalu et al. 2014). SUMOylation of RPA1 recruits RAD51 to sites of DNA damage to initiate repair through homologous recombination.
Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
20705237 Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex

Dou, H, Yeh, ET, Singh, M, Carpenter, PB, Huang, C

Mol. Cell 2010
Participants
Participates
Catalyst Activity

SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]

Orthologous Events
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