Reactome | polySUMO2,3-K449,K577-RPA1 [nucleoplasm]

polySUMO2,3-K449,K577-RPA1 [nucleoplasm]

Stable Identifier

R-HSA-4551644

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA Replication factor A protein A1 (70kD), RPA70, Replication protein A 70 kDa DNA-binding subunit, RP-A, RF-A, Replication factor-A protein 1, Single-stranded DNA-binding protein

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Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014

External Reference Information

External Reference

UniProt:P27694 RPA1

Gene Names

RPA1, REPA1, RPA70

Chain

chain:1-616, initiator methionine:1, chain:2-616

Reference Genes

BioGPS Gene:6117 RPA1

COSMIC (genes):RPA1 RPA1

CTD Gene:6117 RPA1

dbSNP Gene:6117 RPA1

ENSEMBL:ENSG00000132383 RPA1

HGNC:10289 RPA1

KEGG:hsa:6117 RPA1

Monarch:6117 RPA1

NCBI Gene:6117 RPA1

OMIM:179835 RPA1

UCSC:P27694 RPA1

Reference Transcript

RefSeq:NM_002945.5 RPA1

Other Identifiers

11716571_at

11716572_s_at

1382_at

16829580

201528_PM_at

201528_at

201529_PM_s_at

201529_s_at

236675_PM_at

236675_at

3706001

3706002

3706003

3706006

3706007

3706008

3706010

3706011

3706012

3706016

3706017

3706018

3706019

3706020

3706021

3706022

3706023

3706024

3706026

3706028

3706029

3706032

3706033

3706034

3706035

38481_at

59166_at

6117

8003679

A_14_P107237

A_33_P3218951

GE58026

GO:0000228

GO:0000723

GO:0000724

GO:0000781

GO:0000793

GO:0000794

GO:0000800

GO:0001673

GO:0001701

GO:0003676

GO:0003677

GO:0003682

GO:0003684

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005662

GO:0005694

GO:0006260

GO:0006261

GO:0006281

GO:0006284

GO:0006289

GO:0006298

GO:0006310

GO:0006325

GO:0006974

GO:0007004

GO:0008270

GO:0008284

GO:0016605

GO:0022414

GO:0030097

GO:0032200

GO:0034502

GO:0035861

GO:0043047

GO:0046872

GO:0048856

GO:0048873

GO:0051276

GO:0051321

GO:0060090

GO:0090734

GO:0098505

GO:0140463

GO:1990166

HMNXSV003007431

Hs.135292.0.A1_3p_at

Hs.84318.0.S2_3p_at

ILMN_1795719

M63488_at

PH_hs_0004794

TC17000016.hg

TC17002004.hg

g4506582_3p_a_at

Participates

as an output of

SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)

Other forms of this molecule

RPA1 [nucleoplasm]

Inferred To

Homologues of polySUMO2,3-K449,K577-RPA1 [nucleoplasm] (Gallus gallus)

rpa1 [nucleoplasm] (Danio rerio)

Rpa1 [nucleoplasm] (Mus musculus)

Rpa1 [nucleoplasm] (Rattus norvegicus)

RPA1 [nucleoplasm] (Bos taurus)

RPA1 [nucleoplasm] (Gallus gallus)

RPA1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 449

Coordinate

449

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 577

Coordinate

577

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_002936.1

OpenTargets

ENSG00000132383

ENSEMBL

ENSG00000132383, ENST00000254719, ENSP00000254719

HPA

ENSG00000132383-RPA1

GeneCards

RPA1

ZINC - Substances

RFA1_HUMAN

ZINC target

P27694

PRO

P27694

Pharos - Targets

P27694

GlyGen

P27694

ZINC - Predictions - Purchasable

RFA1_HUMAN

PDB

9MJ5, 7XV4, 1L1O, 5N8A, 4R4T, 4IPD, 8K00, 2B29, 4LW1, 4IPG, 7XV0, 4IPH, 4IJH, 8JZV, 1JMC, 4IJL, 7XV1, 7XUW, 4NB3, 5EAY, 9J1S, 4LUO, 4O0A, 8RK2, 4LWC, 8JZY, 4LUV, 4R4I, 5E7N, 4R4O, 4R4C, 5N85, 4LUZ, 4R4Q, 1EWI, 4IPC, 2B3G, 7XUT, 7XUV, 1FGU

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15927 RPA2	2	RPA2 [nucleoplasm] (R-HSA-68457) p-S33-RPA2 [nucleoplasm] (R-HSA-5685148)	0.959	20
UniProt:P35244 RPA3	1	RPA3 [nucleoplasm] (R-HSA-68459)	0.924	11
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.818	9
UniProt:Q13156 RPA4	1	RPA4 [nucleoplasm] (R-HSA-68566)	0.744	8
UniProt:P03070 LT			0.672	4
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.669	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.65	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.643	4
UniProt:Q96LW4 PRIPO			0.623	7
UniProt:P03116 VE1			0.558	2
UniProt:P17066 HSPA6	5	HSPA6 [cytosol] (R-HSA-3371521) HSPA6 [nucleoplasm] (R-HSA-5252088) HSPA6 [ficolin-1-rich granule lumen] (R-HSA-6801512) HSPA6 [extracellular region] (R-HSA-6806500) HSPA6 [secretory granule lumen] (R-HSA-6801472)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q9NZC9 SMAL1			0.527	2
UniProt:Q9H9A7 RMI1	1	RMI1 [nucleoplasm] (R-HSA-5685949)	0.527	2
UniProt:Q9UGP5 POLL	1	POLL [nucleoplasm] (R-HSA-5687352)	0.508	2
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.462	3

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