Reactome | RANBP2 SUMOylates RANBP2 with SUMO1

RANBP2 SUMOylates RANBP2 with SUMO1

Stable Identifier

R-HSA-4551649

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope, nucleoplasm

ReviewStatus

5/5

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RANBP2 SUMOylates RANBP2 at lysine-2592, lysine-2650, and lysine-2723 with SUMO1 (Pichler et al. 2002, Pichler et al. 2004, Cooper et al. 2005). RANBP2 does not resemble HECT or RING type SUMO E3 ligases and instead uses hydrophobic interactions with UBE2I (UBC9) to catalyze SUMOylation.

Literature References

PubMed ID	Title	Journal	Year
16194093	Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction Lam, TT, Tatham, MH, Hay, RT, Heath, JK, Jaffray, E, Cooper, HJ, Marshall, AG	Anal. Chem.	2005
11792325	The nucleoporin RanBP2 has SUMO1 E3 ligase activity Dejean, A, Seeler, JS, Gast, A, Melchior, F, Pichler, A	Cell	2002
15378033	The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type Sixma, TK, Melchior, F, Pichler, A, Saitoh, H, Knipscheer, P	Nat. Struct. Mol. Biol.	2004