PIAS4 SUMOylates HERC2 with SUMO1

Stable Identifier
R-HSA-4551724
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PIAS4 SUMOylates HERC2 at an unknown lysine residue with SUMO1 (Danielsen et al. 2012). HERC2 binds SUMO1 and is then SUMOylated. SUMOylation of HERC2 promotes binding to RNF8 at double-strand breaks in DNA.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events