Reactome | CBX4 SUMOylates CBX4 in PRC1 with SUMO1

CBX4 SUMOylates CBX4 in PRC1 with SUMO1

Stable Identifier

R-HSA-4551727

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CBX4 in Polycomb Repressive Complex 1 (PRC1) autoSUMOylates with SUMO1 (Kagey et al.2005, Roscic et al. 2006, Merrill et al. 2010). As inferred from mouse homologs, SUMOylation of CBX4 appears to be essential for recruitment of the PRC1 complex to histone H3 trimethylated at lysine-27 (H3K27me3) (Kang et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
17018294	Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2 Roscic, A, Möller, A, Calzado, MA, Renner, F, Wimmer, VC, Gresko, E, Lüdi, KS, Schmitz, ML	Mol. Cell	2006
15592428	Multiple activities contribute to Pc2 E3 function Kagey, MH, Melhuish, TA, Powers, SE, Wotton, D	EMBO J.	2005
20098713	A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity Merrill, JC, Melhuish, TA, Kagey, MH, Yang, SH, Sharrocks, AD, Wotton, D	PLoS ONE	2010
20417598	SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development Kang, X, Qi, Y, Zuo, Y, Wang, Q, Zou, Y, Schwartz, RJ, Cheng, J, Yeh, ET	Mol. Cell	2010