Reactome: A Curated Pathway Database

SUMOylation of TDG with SUMO2,3

Stable Identifier
R-HSA-4551738
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TDG is SUMOylated at lysine-330 with SUMO2,3 by UBE2I and perhaps another E3 ligase (Hardeland et al. 2002, Baba et al. 2006, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation increases turnover of TDG with G:U substrate and abolishes activity with G:T substrate (Hardeland et al. 2002).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events