Reactome: A Curated Pathway Database

PIAS4 SUMOylates PARP1 with SUMO2,3

Stable Identifier
R-HSA-4551768
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO2,3 in response to heat shock (Martin et al. 2009, Lamoliatte et al. 2013, Hendriks et al. 2014, Tammsalu et al. 2014). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). SUMOylation of PARP1 is required for full activation of the HSP70.1 promoter (Martin et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of PIAS4 [nucleoplasm] PIAS4 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events