PIAS4 SUMOylates PARP1 with SUMO2,3

Stable Identifier
R-HSA-4551768
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO2,3 in response to heat shock (Martin et al. 2009, Lamoliatte et al. 2013, Hendriks et al. 2014, Tammsalu et al. 2014). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). SUMOylation of PARP1 is required for full activation of the HSP70.1 promoter (Martin et al. 2009).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
PIAS4 [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
PIAS4 SUMOylates PARP1 with SUMO2,3 (Arabidopsis thaliana)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Bos taurus)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Danio rerio)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Gallus gallus)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Oryza sativa)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Sus scrofa)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Taeniopygia guttata)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Xenopus tropicalis)