Reactome | PIAS4 SUMOylates PARP1 with SUMO2,3

PIAS4 SUMOylates PARP1 with SUMO2,3

Stable Identifier

R-HSA-4551768

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Summation

PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO2,3 in response to heat shock (Martin et al. 2009, Lamoliatte et al. 2013, Hendriks et al. 2014, Tammsalu et al. 2014). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). SUMOylation of PARP1 is required for full activation of the HSP70.1 promoter (Martin et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014
19779455	PARP-1 transcriptional activity is regulated by sumoylation upon heat shock Martin, N, Schwamborn, K, Schreiber, V, Werner, A, Guillier, C, Zhang, XD, Bischof, O, Seeler, JS, Dejean, A	EMBO J.	2009
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC	Nat. Struct. Mol. Biol.	2014
23750026	Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions Lamoliatte, F, Bonneil, E, Durette, C, Caron-Lizotte, O, Wildemann, D, Zerweck, J, Wenshuk, H, Thibault, P	Mol. Cell Proteomics	2013