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Ack6-HIST1H2AG [nucleoplasm]
Stable Identifier
R-HSA-4568595
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
AcK6-histone H2A [nucleoplasm] (Homo sapiens)
AcK6-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Ack6-HIST1H2AG [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0C0S8 H2AC11
Gene Names
H2AC11, H2AFP, HIST1H2AG, H2AC13, H2AFC, HIST1H2AI, H2AC15, H2AFD, HIST1H2AK, H2AC16, H2AFI, HIST1H2AL, H2AC17, H2AFN, HIST1H2AM
Chain
initiator methionine:, chain:2-130
Reference Genes
BioGPS Gene:8329 H2AC11
BioGPS Gene:8330 H2AC11
BioGPS Gene:8332 H2AC11
BioGPS Gene:8336 H2AC11
BioGPS Gene:8969 H2AC11
COSMIC (genes):HIST1H2AG H2AC11
COSMIC (genes):HIST1H2AI H2AC11
COSMIC (genes):HIST1H2AK H2AC11
COSMIC (genes):HIST1H2AL H2AC11
COSMIC (genes):HIST1H2AM H2AC11
CTD Gene:8329 H2AC11
CTD Gene:8330 H2AC11
CTD Gene:8332 H2AC11
CTD Gene:8336 H2AC11
CTD Gene:8969 H2AC11
dbSNP Gene:8329 H2AC11
dbSNP Gene:8330 H2AC11
dbSNP Gene:8332 H2AC11
dbSNP Gene:8336 H2AC11
dbSNP Gene:8969 H2AC11
ENSEMBL:ENSG00000196747 HIST1H2AI
ENSEMBL:ENSG00000196787 HIST1H2AG
ENSEMBL:ENSG00000275221 HIST1H2AK
ENSEMBL:ENSG00000276903 HIST1H2AL
ENSEMBL:ENSG00000278677 HIST1H2AM
HGNC:4725 H2AC11
HGNC:4726 H2AC11
HGNC:4730 H2AC11
HGNC:4735 H2AC11
HGNC:4737 H2AC11
KEGG:hsa:8329 H2AC11
KEGG:hsa:8330 H2AC11
KEGG:hsa:8332 H2AC11
KEGG:hsa:8336 H2AC11
KEGG:hsa:8969 H2AC11
Monarch:8329 H2AC11
Monarch:8330 H2AC11
Monarch:8332 H2AC11
Monarch:8336 H2AC11
Monarch:8969 H2AC11
NCBI Gene:8329 H2AC11
NCBI Gene:8330 H2AC11
NCBI Gene:8332 H2AC11
NCBI Gene:8336 H2AC11
NCBI Gene:8969 H2AC11
OMIM:602787 H2AC11
OMIM:602788 H2AC11
OMIM:602793 H2AC11
OMIM:602796 H2AC11
OMIM:615012 H2AC11
UCSC:P0C0S8 H2AC11
Reference Transcript
RefSeq:NM_003509.2 H2AC11
RefSeq:NM_021064.4 H2AC11
RefSeq:NM_003511.2 H2AC11
RefSeq:NM_003510.2 H2AC11
RefSeq:NM_003514.2 H2AC11
Other Identifiers
11715162_s_at
11715219_s_at
11734234_at
11737572_x_at
11740124_at
11740125_x_at
11759131_at
11759219_at
11759220_at
11759248_at
11759252_at
11759253_x_at
17005787
17005858
17005876
17016496
17016512
207156_PM_at
207156_at
208583_PM_x_at
208583_x_at
214542_PM_x_at
214542_x_at
214554_PM_at
214554_at
214644_PM_at
214644_at
239041_PM_at
239041_at
284_at
285_g_at
2899757
2899758
2899759
2899760
2899761
2899762
2899763
2899764
2899765
2899767
2900048
2900094
2900095
2900096
2947042
2947043
2947044
2947045
2947061
2947062
2947064
2947065
2947066
2947103
2947104
2947105
31749_f_at
31768_at
33023_at
34156_i_at
34157_f_at
8117535
8117580
8117608
8124524
8124540
8329
8330
8332
8336
83824_at
8969
ADDON002309.hg
ADDON002495.hg
ADDON002786.hg
ADDON002787.hg
ADDON002823.hg
A_14_P122277
A_14_P122573
A_14_P200168
A_14_P200169
A_21_P0000197
A_23_P168014
A_23_P363174
A_24_P217848
A_24_P303354
A_24_P394510
A_24_P414658
A_24_P86389
A_24_P940441
A_32_P221799
A_33_P3360216
GE535482
GE57662
GE81292
GE81293
GE81294
GO:0000786
GO:0003677
GO:0005198
GO:0005515
GO:0005634
GO:0005694
GO:0006325
GO:0008150
GO:0019899
GO:0030527
GO:0031492
GO:0031507
GO:0043226
GO:0043229
GO:0046982
GO:0070062
HMNXSV003003032
HMNXSV003009155
HMNXSV003020688
HMNXSV003021084
HMNXSV003039464
HMNXSV003050773
Hs.131954.0.S2_3p_at
Hs.137592.0.S1_3p_at
Hs.137592.0.S1_3p_x_at
Hs.158088.0.A1_3p_at
Hs.233568.0.S1_3p_at
ILMN_1663453
ILMN_1686478
ILMN_1694699
ILMN_1756022
ILMN_2184602
L19778_at
PH_hs_0007861
PH_hs_0028903
PH_hs_0031765
TC06000223.hg
TC06000269.hg
TC06001425.hg
TC06001430.hg
TC06004063.hg
Z83742_at
g10800131_3p_at
Participates
as a member of
AcK6-histone HIST1H2A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ack-HIST1H2AG [nucleoplasm]
HIST1H2AG [nucleoplasm]
MeR12-HIST1H2AG [nucleoplasm]
Me2aR12-HIST1H2AG [nucleoplasm]
MeR4-HIST1H2AG [nucleoplasm]
Me2aR4-HIST1H2AG [nucleoplasm]
MeR30-HIST1H2AG [nucleoplasm]
Me2aR30-HIST1H2AG [nucleoplasm]
Ub-HIST1H2AG [nucleoplasm]
K63polyUb-HIST1H2AG [nucleoplasm]
Inferred To
LOC100485548 [nucleoplasm]
(Xenopus tropicalis)
hta2 [nucleoplasm]
(Schizosaccharomyces pombe)
H2AC13 [nucleoplasm]
(Canis familiaris)
LOC100487632 [nucleoplasm]
(Xenopus tropicalis)
LOC116411633 [nucleoplasm]
(Xenopus tropicalis)
h2ac16 [nucleoplasm]
(Xenopus tropicalis)
LOC116407737 [nucleoplasm]
(Xenopus tropicalis)
LOC100487067 [nucleoplasm]
(Xenopus tropicalis)
h2ax1 [nucleoplasm]
(Danio rerio)
Ack6-HIST1H2AB [nucleoplasm]
(Gallus gallus)
Ack6-HIST1H2AB [nucleoplasm]
(Plasmodium falciparum)
HTA1 [nucleoplasm]
(Saccharomyces cerevisiae)
H2AC10 [nucleoplasm]
(Bos taurus)
HTA2 [nucleoplasm]
(Saccharomyces cerevisiae)
zgc:56685 [nucleoplasm]
(Danio rerio)
H2Av2 [nucleoplasm]
(Dictyostelium discoideum)
H2AX [nucleoplasm]
(Dictyostelium discoideum)
H2Av3 [nucleoplasm]
(Dictyostelium discoideum)
His2A:CG33862 [nucleoplasm]
(Drosophila melanogaster)
H2Av1 [nucleoplasm]
(Dictyostelium discoideum)
hta1 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of Ack6-HIST1H2AB [nucleoplasm]
(Danio rerio)
Homologues of Ack6-HIST1H2AB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ack6-HIST1H2AB [nucleoplasm]
(Drosophila melanogaster)
Homologues of Ack6-HIST1H2AB [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Ack6-HIST1H2AB [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of Ack6-HIST1H2AB [nucleoplasm]
(Xenopus tropicalis)
LOC101732059 [nucleoplasm]
(Xenopus tropicalis)
His2A:CG33859 [nucleoplasm]
(Drosophila melanogaster)
H2AC14 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
N6-acetyl-L-lysine at 6
Coordinate
6
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
NP_066408.1
,
NP_003505.1
,
NP_003502.1
,
NP_003500.1
,
NP_003501.1
OpenTargets
ENSG00000276903
,
ENSG00000196787
,
ENSG00000275221
,
ENSG00000196747
,
ENSG00000278677
ENSEMBL
ENST00000358739
,
ENST00000618958
,
ENSP00000482431
,
ENSP00000482538
,
ENSP00000352627
,
ENST00000613174
,
ENST00000359193
,
ENST00000359611
,
ENSP00000351589
,
ENSP00000352119
HPA
ENSG00000276903-H2AC16
,
ENSG00000278677-H2AC17
,
ENSG00000196747-H2AC13
,
ENSG00000196787-H2AC11
,
ENSG00000275221-H2AC15
PRO
P0C0S8
Pharos - Targets
P0C0S8
GlyGen
P0C0S8
HMDB Protein
HMDBP07725
PDB
5KGF
,
6XJD
,
7U53
,
8OFF
,
6R0C
,
7U50
,
7U52
,
6X5A
,
8ATF
,
7BG9
,
7JO9
,
7UV9
,
8GUI
,
6RNY
,
8GUK
,
6X59
,
7E8D
,
7JOA
,
7U51
,
4QYL
,
8GUJ
,
7TAN
,
8AV6
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12888 TP53BP1
3
TP53BP1 [nucleoplasm]
(R-HSA-61175)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
0.672
21
UniProt:P84233 Unknown
2
Histone H3.2 [nucleoplasm]
(R-XLA-4549227)
Ack15-histone H3.2 [nucleoplasm]
(R-XLA-4549248)
0.65
14
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.65
14
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.643
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.527
2
UniProt:P06746 POLB
2
POLB [nucleoplasm]
(R-HSA-53845)
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
0.527
2
UniProt:P34741 SDC2
20
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
HS(3)-SDC2 [plasma membrane]
(R-HSA-2076631)
HS(5)-SDC2 [plasma membrane]
(R-HSA-2076665)
SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956741)
p-SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956945)
XylS-SDC2 [Golgi lumen]
(R-HSA-2064109)
Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2064132)
SDC2 [Golgi lumen]
(R-HSA-2054101)
Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063988)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
0.527
2
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.527
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
2
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
3
UniProt:Q01831 XPC
5
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
XPC [nucleoplasm]
(R-HSA-67441)
0.527
4
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.527
2
UniProt:O95760 IL33
3
IL33 [extracellular region]
(R-HSA-448567)
PolyUb-IL33 [nucleoplasm]
(R-HSA-6783057)
IL33 [nucleoplasm]
(R-HSA-6783145)
0.499
3
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