Reactome: A Curated Pathway Database

CDKN2A (p14-ARF) SUMOylates WRN with SUMO1

Stable Identifier
R-HSA-4568846
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Summation

CDKN2A (p14-ARF) SUMOylates WRN at lysine-356, lysine-496, and lysine-898 with SUMO1 (Woods et al. 2004). SUMOylation of WRN causes it to be released from the nucleolus.

Literature References
PubMed ID Title Journal Year
15355988 p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase J. Biol. Chem. 2004
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of p14-ARF [nucleoplasm] p14-ARF [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events
 
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