CDKN2A (p14-ARF) SUMOylates WRN with SUMO1

Stable Identifier
R-HSA-4568846
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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CDKN2A (p14-ARF) SUMOylates WRN with SUMO1
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CDKN2A (p14-ARF) SUMOylates WRN at lysine-356, lysine-496, and lysine-898 with SUMO1 (Woods et al. 2004). SUMOylation of WRN causes it to be released from the nucleolus.

Literature References
PubMed ID Title Journal Year
15355988 p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, YL, Xirodimas, DP, Prescott, AR, Sparks, A, Lane, DP, Saville, MK

J. Biol. Chem. 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of p14ARF [nucleoplasm]
Physical Entity
p14ARF [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Authored
May, B  (2013-09-14)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-09-19)
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