Reactome: A Curated Pathway Database

PIAS1,2-1 SUMOylates XRCC4 with SUMO1

Stable Identifier
R-HSA-4568848
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PIAS1,2-1 SUMOylate XRCC4 at lysine-210 with SUMO1 (Yurchenko et al. 2006). SUMOylation causes localization of XRCC4 to the nucleus. (An unSUMOylatable mutant of XRCC4 is localized to the cytosol.)

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of PIAS1,2-1 [nucleoplasm] PIAS1,2-1 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events