SUMOylation of BLM with SUMO2,3

Stable Identifier
R-HSA-4568914
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

BLM is SUMOylated at lysine-317, lysine-331, lysine-344, and lysine-347 with SUMO2,3 (Eladad et al. 2005, Zhu et al. 2008, Ouyang et al. 2009, Ouyang et al. 2013, Hendriks et al. 2014). SUMOylation causes BLM to localize to PML bodies (Eladad et al. 2005). SUMOylated BLM recruits RAD51, which directly binds SUMO, and facilitates the substitution of RAD51 for RPA at stalled replication forks (Ouyang et al. 2009, 2013).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events