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monoSUMO1-K655-XPC [nucleoplasm]
Stable Identifier
R-HSA-4570458
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein complementing XP-C cells, XPC_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
SUMOylation of XPC with SUMO1 (Homo sapiens)
monoSUMO1-K655-XPC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01831 XPC
Gene Names
XPC, XPCC
Chain
initiator methionine:, chain:2-940
Reference Genes
BioGPS Gene:7508 XPC
COSMIC (genes):XPC XPC
CTD Gene:7508 XPC
dbSNP Gene:7508 XPC
ENSEMBL:ENSG00000154767 XPC
HGNC:12816 XPC
KEGG:hsa:7508 XPC
Monarch:7508 XPC
NCBI Gene:7508 XPC
OMIM:613208 XPC
UCSC:Q01831 XPC
Reference Transcript
RefSeq:NM_004628.4 XPC
Participates
as an output of
SUMOylation of XPC with SUMO1 (Homo sapiens)
Other forms of this molecule
XPC [nucleoplasm]
Ub-XPC [nucleoplasm]
Ub,SUMO-XPC [nucleoplasm]
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
Inferred To
XPC [nucleoplasm]
(Sus scrofa)
rad4 [nucleoplasm]
(Dictyostelium discoideum)
xpc-1 [nucleoplasm]
(Caenorhabditis elegans)
RAD34 [nucleoplasm]
(Saccharomyces cerevisiae)
Xpc [nucleoplasm]
(Mus musculus)
Xpc [nucleoplasm]
(Rattus norvegicus)
monoSUMO1-K655-XPC [nucleoplasm]
(Bos taurus)
monoSUMO1-K655-XPC [nucleoplasm]
(Gallus gallus)
monoSUMO1-K655-XPC [nucleoplasm]
(Plasmodium falciparum)
rhp42 [nucleoplasm]
(Schizosaccharomyces pombe)
xpc [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 655
Coordinate
655
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
OpenTargets
ENSG00000154767
ENSEMBL
ENSP00000424548
,
ENST00000476581
,
ENST00000285021
,
ENSP00000285021
,
ENSG00000154767
GeneCards
XPC
HPA
ENSG00000154767-XPC
PRO
Q01831
Pharos - Targets
Q01831
GlyGen
Q01831
Orphanet
XPC
HMDB Protein
HMDBP12797
PDB
8EBU
,
2RVB
,
2GGM
,
8EBW
,
8EBX
,
2A4J
,
8EBT
,
8EBS
,
2OBH
,
8EBY
,
8EBV
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41208 CETN2
3
CETN2 [cytosol]
(R-HSA-380298)
CETN2 [nucleoplasm]
(R-HSA-4570490)
polySUMO2,3-CETN2 [nucleoplasm]
(R-HSA-4570486)
0.901
14
UniProt:P54727 RAD23B
2
RAD23B [nucleoplasm]
(R-HSA-62590)
RAD23B [cytosol]
(R-HSA-8850589)
0.869
14
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.725
5
UniProt:O15182 CETN3
0.725
8
UniProt:P13288 KR2
0.645
9
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.643
4
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.643
6
UniProt:P12956 XRCC6
5
XRCC6 [nucleoplasm]
(R-HSA-58272)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
0.643
3
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.643
4
UniProt:Q9NRW3 APOBEC3C
1
APOBEC3C [nucleoplasm]
(R-HSA-8874997)
0.643
3
UniProt:P19447 ERCC3
1
ERCC3 [nucleoplasm]
(R-HSA-67439)
0.59
3
UniProt:P32780 GTF2H1
1
GTF2H1 [nucleoplasm]
(R-HSA-65912)
0.59
3
UniProt:Q9R1K9
3
polySUMO2,3-CETN2 [nucleoplasm]
(R-MMU-4570486)
CETN2 [nucleoplasm]
(R-MMU-4570490)
CETN2 [cytosol]
(R-MMU-380298)
0.564
2
UniProt:P67870 CSNK2B
5
CSNK2B [cytosol]
(R-HSA-201693)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
0.527
2
UniProt:P06746 POLB
2
POLB [nucleoplasm]
(R-HSA-53845)
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
0.527
2
UniProt:P23527 H2BC17
9
Ub-HIST1H2BO [nucleoplasm]
(R-HSA-6782549)
AcK-HIST1H2BO [nucleoplasm]
(R-HSA-4549268)
HIST1H2BO [extracellular region]
(R-HSA-977557)
AcK13-HIST1H2BO [nucleoplasm]
(R-HSA-4568712)
AcK21-HIST1H2BO [nucleoplasm]
(R-HSA-4568713)
AcK16-HIST1H2BO [nucleoplasm]
(R-HSA-4568681)
AcK6-HIST1H2BO [nucleoplasm]
(R-HSA-4568708)
Ub-121-HIST1H2BO [nucleoplasm]
(R-HSA-3364033)
HIST1H2BO [nucleoplasm]
(R-HSA-181910)
0.527
3
UniProt:Q12798 CETN1
7
PolyUb-Misfolded CETN1 [late endosome lumen]
(R-HSA-9659982)
CETN1 [cilium]
(R-HSA-9639700)
Misfolded CETN1 [cilium]
(R-HSA-9639714)
Misfolded CETN1 [cytosol]
(R-HSA-9640113)
Ub-Misfolded CETN1 [cytosol]
(R-HSA-9641110)
PolyUb-Misfolded CETN1 [cytosol]
(R-HSA-9641126)
PolyUb-Misfolded CETN1 [lysosomal lumen]
(R-HSA-9659990)
0.527
5
UniProt:P0C0S5 H2AZ1
1
H2AFZ [extracellular region]
(R-HSA-977575)
0.527
4
UniProt:O75367 H2AY
0.527
4
UniProt:Q9P0M6 H2AW
0.527
3
UniProt:P0C0S8 H2AC11
11
Ack-HIST1H2AG [nucleoplasm]
(R-HSA-4551311)
HIST1H2AG [nucleoplasm]
(R-HSA-212084)
MeR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229206)
Me2aR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229305)
MeR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244623)
Me2aR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244587)
MeR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244560)
Me2aR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244582)
Ack6-HIST1H2AG [nucleoplasm]
(R-HSA-4568595)
Ub-HIST1H2AG [nucleoplasm]
(R-HSA-6782508)
K63polyUb-HIST1H2AG [nucleoplasm]
(R-HSA-6783237)
0.527
4
UniProt:Q8IW19 APLF
0.527
2
UniProt:P58876 H2BC5
9
Ub-HIST1H2BD [nucleoplasm]
(R-HSA-6782546)
AcK-HIST1H2BD [nucleoplasm]
(R-HSA-4549255)
HIST1H2BD [extracellular region]
(R-HSA-977561)
AcK16-HIST1H2BD [nucleoplasm]
(R-HSA-4568633)
AcK6-HIST1H2BD [nucleoplasm]
(R-HSA-4568642)
AcK21-HIST1H2BD [nucleoplasm]
(R-HSA-4568627)
AcK13-HIST1H2BD [nucleoplasm]
(R-HSA-4568645)
Ub-121-HIST1H2BD [nucleoplasm]
(R-HSA-3364025)
HIST1H2BD [nucleoplasm]
(R-HSA-181912)
0.527
3
UniProt:P34741 SDC2
20
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
HS(3)-SDC2 [plasma membrane]
(R-HSA-2076631)
HS(5)-SDC2 [plasma membrane]
(R-HSA-2076665)
SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956741)
p-SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956945)
SDC2 [Golgi lumen]
(R-HSA-2054101)
XylS-SDC2 [Golgi lumen]
(R-HSA-2064109)
Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2064132)
Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063988)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
0.527
2
UniProt:Q9BPZ2 SPI2B
0.527
2
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.527
3
UniProt:Q86UY6 NAA40
0.527
2
UniProt:Q13156 RPA4
1
RPA4 [nucleoplasm]
(R-HSA-68566)
0.527
3
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
3
UniProt:Q9BQ69 MACD1
0.527
2
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
3
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
MeK80-HIST1H3A [nucleoplasm]
(R-HSA-5649791)
0.483
2
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