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monoSUMO1-K655-XPC [nucleoplasm]
Stable Identifier
R-HSA-4570458
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA repair protein complementing XP-C cells, XPC_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P32780 GTF2H1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
SUMOylation of XPC with SUMO1 (Homo sapiens)
monoSUMO1-K655-XPC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01831 XPC
Gene Names
XPC, XPCC
Chain
initiator methionine:, chain:2-940
Reference Genes
BioGPS Gene:7508 XPC
COSMIC (genes):XPC XPC
CTD Gene:7508 XPC
dbSNP Gene:7508 XPC
ENSEMBL:ENSG00000154767 XPC
ENSEMBL_homo_sapiens_GENE:ENSG00000154767.15 XPC
HGNC:12816 XPC
KEGG Gene (Homo sapiens):7508 XPC
Monarch:7508 XPC
NCBI Gene:7508 XPC
OMIM:613208 XPC
UCSC:Q01831 XPC
Reference Transcript
RefSeq:NM_004628.4 XPC
Other Identifiers
11728207_a_at
11740553_a_at
16951007
1873_at
209375_PM_at
209375_at
2663807
2663809
2663811
2663812
2663813
2663814
2663815
2663817
2663820
2663823
2663824
2663828
2663834
2663835
2663836
2663837
2663839
2663840
2663841
2663842
2663843
2663844
2663847
2663848
2663849
2663850
2663851
2663852
2663853
2663855
2663856
35647_at
7508
8085486
D21089_at
GE57108
GO:0000109
GO:0000111
GO:0000278
GO:0000404
GO:0000405
GO:0000720
GO:0000785
GO:0003677
GO:0003684
GO:0003697
GO:0003713
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006281
GO:0006289
GO:0006298
GO:0006351
GO:0006355
GO:0006974
GO:0009410
GO:0010224
GO:0010996
GO:0023052
GO:0031573
GO:0043226
GO:0043231
GO:0044877
GO:0045893
GO:0061629
GO:0070914
GO:0071942
GO:0090734
GO:0140110
GO:0140299
GO:0140612
GO:1901990
HMNXSV003012819
HMNXSV003019064
ILMN_1790807
PH_hs_0000038
PH_hs_0030850
TC03001194.hg
TC03002817.hg
g475156_3p_at
Participates
as an output of
SUMOylation of XPC with SUMO1 (Homo sapiens)
Other forms of this molecule
XPC [nucleoplasm]
Ub-XPC [nucleoplasm]
Ub,SUMO-XPC [nucleoplasm]
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
Inferred To
XPC [nucleoplasm]
(Sus scrofa)
rad4 [nucleoplasm]
(Dictyostelium discoideum)
xpc-1 [nucleoplasm]
(Caenorhabditis elegans)
RAD34 [nucleoplasm]
(Saccharomyces cerevisiae)
Xpc [nucleoplasm]
(Mus musculus)
Xpc [nucleoplasm]
(Rattus norvegicus)
monoSUMO1-K655-XPC [nucleoplasm]
(Bos taurus)
monoSUMO1-K655-XPC [nucleoplasm]
(Gallus gallus)
monoSUMO1-K655-XPC [nucleoplasm]
(Plasmodium falciparum)
rhp42 [nucleoplasm]
(Schizosaccharomyces pombe)
xpc [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 655
Coordinate
655
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_004619.3
OpenTargets
ENSG00000154767
GeneCards
Q01831
HPA
ENSG00000154767-XPC
Ensembl
ENST00000476581
,
ENSP00000424548
,
ENSP00000285021
,
ENST00000285021
,
ENSG00000154767
PRO
Q01831
Pharos - Targets
Q01831
Orphanet
15736
HMDB Protein
HMDBP12797
PDB
8EBW
,
8EBS
,
2OBH
,
2GGM
,
8EBY
,
8EBU
,
2RVB
,
8EBT
,
8EBV
,
2A4J
,
8EBX
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41208 CETN2
3
CETN2 [cytosol]
(R-HSA-380298)
CETN2 [nucleoplasm]
(R-HSA-4570490)
polySUMO2,3-CETN2 [nucleoplasm]
(R-HSA-4570486)
0.901
14
UniProt:P54727 RAD23B
2
RAD23B [nucleoplasm]
(R-HSA-62590)
RAD23B [cytosol]
(R-HSA-8850589)
0.869
14
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.725
5
UniProt:O15182 CETN3
0.725
8
UniProt:P13288 KR2
0.645
9
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.643
4
UniProt:Q9NRW3 APOBEC3C
1
APOBEC3C [nucleoplasm]
(R-HSA-8874997)
0.643
3
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.643
4
UniProt:P12956 XRCC6
5
XRCC6 [secretory granule lumen]
(R-HSA-6801312)
XRCC6 [extracellular region]
(R-HSA-6806444)
XRCC6 [ficolin-1-rich granule lumen]
(R-HSA-6801300)
XRCC6 [cytosol]
(R-HSA-3134813)
XRCC6 [nucleoplasm]
(R-HSA-58272)
0.643
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.643
6
UniProt:P32780 GTF2H1
1
GTF2H1 [nucleoplasm]
(R-HSA-65912)
0.59
3
UniProt:P19447 ERCC3
1
ERCC3 [nucleoplasm]
(R-HSA-67439)
0.59
3
UniProt:Q9R1K9
3
polySUMO2,3-CETN2 [nucleoplasm]
(R-MMU-4570486)
CETN2 [nucleoplasm]
(R-MMU-4570490)
CETN2 [cytosol]
(R-MMU-380298)
0.564
2
UniProt:P67870 CSNK2B
5
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [cytosol]
(R-HSA-201693)
0.527
2
UniProt:Q9BQ69 MACD1
0.527
2
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
3
UniProt:Q13156 RPA4
1
RPA4 [nucleoplasm]
(R-HSA-68566)
0.527
3
UniProt:Q86UY6 NAA40
0.527
2
UniProt:Q9BPZ2 SPI2B
0.527
2
UniProt:P58876 H2BC5
9
Ub-HIST1H2BD [nucleoplasm]
(R-HSA-6782546)
AcK-HIST1H2BD [nucleoplasm]
(R-HSA-4549255)
HIST1H2BD [extracellular region]
(R-HSA-977561)
AcK16-HIST1H2BD [nucleoplasm]
(R-HSA-4568633)
AcK6-HIST1H2BD [nucleoplasm]
(R-HSA-4568642)
AcK21-HIST1H2BD [nucleoplasm]
(R-HSA-4568627)
AcK13-HIST1H2BD [nucleoplasm]
(R-HSA-4568645)
Ub-121-HIST1H2BD [nucleoplasm]
(R-HSA-3364025)
HIST1H2BD [nucleoplasm]
(R-HSA-181912)
0.527
3
UniProt:Q8IW19 APLF
0.527
2
UniProt:P0C0S8 H2AC11
11
K63polyUb-HIST1H2AG [nucleoplasm]
(R-HSA-6783237)
Ub-HIST1H2AG [nucleoplasm]
(R-HSA-6782508)
Ack6-HIST1H2AG [nucleoplasm]
(R-HSA-4568595)
Me2aR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244582)
MeR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244560)
Me2aR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244587)
MeR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244623)
Me2aR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229305)
MeR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229206)
HIST1H2AG [nucleoplasm]
(R-HSA-212084)
Ack-HIST1H2AG [nucleoplasm]
(R-HSA-4551311)
0.527
4
UniProt:Q9P0M6 H2AW
0.527
3
UniProt:O75367 H2AY
0.527
4
UniProt:P0C0S5 H2AZ1
1
H2AFZ [extracellular region]
(R-HSA-977575)
0.527
4
UniProt:Q12798 CETN1
7
PolyUb-Misfolded CETN1 [late endosome lumen]
(R-HSA-9659982)
CETN1 [cilium]
(R-HSA-9639700)
Misfolded CETN1 [cilium]
(R-HSA-9639714)
Misfolded CETN1 [cytosol]
(R-HSA-9640113)
Ub-Misfolded CETN1 [cytosol]
(R-HSA-9641110)
PolyUb-Misfolded CETN1 [cytosol]
(R-HSA-9641126)
PolyUb-Misfolded CETN1 [lysosomal lumen]
(R-HSA-9659990)
0.527
5
UniProt:P23527 H2BC17
9
Ub-HIST1H2BO [nucleoplasm]
(R-HSA-6782549)
AcK-HIST1H2BO [nucleoplasm]
(R-HSA-4549268)
HIST1H2BO [extracellular region]
(R-HSA-977557)
AcK13-HIST1H2BO [nucleoplasm]
(R-HSA-4568712)
AcK21-HIST1H2BO [nucleoplasm]
(R-HSA-4568713)
AcK16-HIST1H2BO [nucleoplasm]
(R-HSA-4568681)
AcK6-HIST1H2BO [nucleoplasm]
(R-HSA-4568708)
Ub-121-HIST1H2BO [nucleoplasm]
(R-HSA-3364033)
HIST1H2BO [nucleoplasm]
(R-HSA-181910)
0.527
3
UniProt:P06746 POLB
2
PolyUb-POLB [nucleoplasm]
(R-HSA-6783152)
POLB [nucleoplasm]
(R-HSA-53845)
0.527
2
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.527
3
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
3
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.527
2
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.483
2
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