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CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3
Stable Identifier
R-HSA-4570463
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CBX4 (Pc2) in the PRC1 complex SUMOylates CETN2 at an unknown residue with SUMO2,3 (Klein and Nigg 2009). SUMOylation of CETN2 enhances its nuclear localization. Interaction with XPC is also required for nuclear localization of CETN2.
Literature References
PubMed ID
Title
Journal
Year
19706679
SUMO-dependent regulation of centrin-2
Nigg, EA
,
Klein, UR
J. Cell. Sci.
2009
Participants
Input
CETN2 [nucleoplasm]
(Homo sapiens)
x 2
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
(Homo sapiens)
Output
polySUMO2,3-CETN2 [nucleoplasm]
(Homo sapiens)
x 2
UBE2I [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
Catalyst Activity
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
PRC1 complex [nucleoplasm]
(Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Bos taurus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Sus scrofa)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)
Authored
May, B (2013-09-19)
Reviewed
Ferrari, S (2015-02-21)
Created
May, B (2013-09-21)
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