CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3

Stable Identifier
R-HSA-4570463
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CBX4 (Pc2) in the PRC1 complex SUMOylates CETN2 at an unknown residue with SUMO2,3 (Klein and Nigg 2009). SUMOylation of CETN2 enhances its nuclear localization. Interaction with XPC is also required for nuclear localization of CETN2.

Literature References
PubMed ID Title Journal Year
19706679 SUMO-dependent regulation of centrin-2 J. Cell. Sci. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events