SUMOylation of RNA binding proteins

Stable Identifier
R-HSA-4570464
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

SUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affinity for nucleic acid (ssDNA), SUMOylation of NOP58 is required for binding of snoRNAs. SUMOylation of HNRNPK is required for its coactivation of TP53-dependent transcription.

Literature References
PubMed ID Title Journal Year
15161980 Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis

Li, T, Evdokimov, E, Shen, RF, Chao, CC, Tekle, E, Wang, T, Stadtman, ER, Yang, DC, Chock, PB

Proc. Natl. Acad. Sci. U.S.A. 2004
23979992 Proteomics Strategies to Identify SUMO Targets and Acceptor Sites: A Survey of RNA-Binding Proteins SUMOylation

Filosa, G, Barabino, SM, Bachi, A

Neuromolecular Med. 2013
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