SUMOylation of RNA binding proteins

Stable Identifier
R-HSA-4570464
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of RNA binding proteins
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SUMOylation of RNA-binding proteins (Li et al. 2004, reviewed in Filosa et al. 2013) alters their interactions with nucleic acids and with proteins. Whereas SUMOylation of HNRNPC decreases its affinity for nucleic acid (ssDNA), SUMOylation of NOP58 is required for binding of snoRNAs. SUMOylation of HNRNPK is required for its coactivation of TP53-dependent transcription.
Literature References
PubMed ID Title Journal Year
23979992 Proteomics Strategies to Identify SUMO Targets and Acceptor Sites: A Survey of RNA-Binding Proteins SUMOylation

Filosa, G, Barabino, SM, Bachi, A

Neuromolecular Med. 2013
15161980 Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis

Li, T, Evdokimov, E, Shen, RF, Chao, CC, Tekle, E, Wang, T, Stadtman, ER, Yang, DC, Chock, PB

Proc. Natl. Acad. Sci. U.S.A. 2004
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Orthologous Events
SUMOylation of RNA binding proteins (Bos taurus)
SUMOylation of RNA binding proteins (Caenorhabditis elegans)
SUMOylation of RNA binding proteins (Danio rerio)
SUMOylation of RNA binding proteins (Dictyostelium discoideum)
SUMOylation of RNA binding proteins (Drosophila melanogaster)
SUMOylation of RNA binding proteins (Gallus gallus)
SUMOylation of RNA binding proteins (Mus musculus)
SUMOylation of RNA binding proteins (Plasmodium falciparum)
SUMOylation of RNA binding proteins (Rattus norvegicus)
SUMOylation of RNA binding proteins (Saccharomyces cerevisiae)
SUMOylation of RNA binding proteins (Schizosaccharomyces pombe)
SUMOylation of RNA binding proteins (Sus scrofa)
SUMOylation of RNA binding proteins (Xenopus tropicalis)
Authored
May, B  (2013-09-19)
Reviewed
Filosa, G  (2015-10-17)
Bachi, A  (2015-10-17)
Created
May, B  (2013-09-21)
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