Reactome: A Curated Pathway Database

SUMO2,3-K1840-MDC1

Stable Identifier
R-HSA-4570473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Mediator of DNA damage checkpoint protein 1, MDC1_HUMAN
Locations in the PathwayBrowser
Literature References
External Reference Information
External Reference
Gene Names
MDC1, KIAA0170, NFBD1
Chain
chain:1-2089
Reference Genes
Reference Transcript
Other Identifiers
 0006200402  11748150_a_at  11748405_a_at  11751800_a_at  11758138_s_at
 17016966  17026706  17028857  17031635  17034090
 17036357  17039133  17041700  203061_s_at  203062_s_at
 2948565  2948566  2948567  2948568  2948569
 2948570  2948571  2948572  2948574  2948575
 2948577  2948578  2948579  2948580  2948581
 2948582  2948583  2948584  2948586  2ADO
 2AZM  2ETX  32661_s_at  32662_at  3K05
 3UEO  3UMZ  3UN0  3UNM  3UNN
 3UOT  6915  8124813  8178404  9656
 A0A1U9XBC1  A0A1U9XBE3  A0A1U9XBF2  A_23_P19455  AAI10646
 AAI52557  AB088099  AB103605  AB202097  AL662797
 AL662848  AL845353  AQY78598  AQY78600  AQY78604
 AQY78607  AQY78609  BA000025  BAA11487  BAB63322
 BAC54931  BAE78617  BAF31266  BC110645  BC152556
 BX248307  BX927283  CAH18685  CAI17440  CAI18195
 CAI41890  CAI41891  CAM24847  CAM25512  CAM25928
 CAM25929  CAQ06769  CAQ06770  CAQ06813  CAQ06814
 CAQ07571  CAQ07572  CAQ08690  CAQ08691  CCDS34384
 CH471081  CR749828  CR759873  CR788240  CR936878
 D79992  D79992_at  EAX03321  ENSG00000137337  ENSG00000206481
 ENSG00000224587  ENSG00000225589  ENSG00000228575  ENSG00000231135  ENSG00000234012
 ENSG00000237095  ENSP00000365588  ENSP00000373060  ENSP00000387429  ENSP00000396484
 ENSP00000404318  ENSP00000409167  ENSP00000415212  ENSP00000416511  ENST00000376406
 ENST00000383566  ENST00000420019  ENST00000420320  ENST00000427406  ENST00000435664
 ENST00000440369  ENST00000449153  EntrezGene:9656  g7661965_3p_a_at  GE87930
 GO:0000278  GO:0003674  GO:0005515  GO:0005575  GO:0005622
 GO:0005623  GO:0005634  GO:0005654  GO:0005694  GO:0005925
 GO:0006259  GO:0006281  GO:0006303  GO:0006950  GO:0006974
 GO:0007049  GO:0008022  GO:0008150  GO:0016604  GO:0031573
 GO:0034641  GO:0043226  GO:0070975  HGNC:21163  HPA006915
 Hs.277585.0.A1_3p_a_at  Hs.653495  ILMN_1814122  IPR000253  IPR001357
 IPR008984  KY500445  KY500447  KY500451  KY500454
 KY500456  MDC1  MDC1-201  MDC1-210  MDC1-219
 MDC1-228  MDC1-240  MDC1-248  MDC1-255  MDC1-266
 MIM:607593  NM_014641  NP_055456  PF00498  PF16770
 PH_hs_0020142  SM00240  TC06001507.hg  TC6_apd_hap1000077.hg  TC6_cox_hap2000141.hg
 TC6_dbb_hap3000130.hg  TC6_mann_hap4000119.hg  TC6_mcf_hap5000120.hg  TC6_qbl_hap6000131.hg  TC6_ssto_hap7000121.hg
 uc003nrg.5  UPI00001AF453  UPI00004A3B34  UPI0000EE070F  XM_005249492
 XM_005249493  XM_005249494  XM_005249497  XM_005249498  XM_011515001
 XM_011515003  XM_011515004  XM_017011519  XM_017011520  XM_017011521
 XM_017011522  XP_005249549  XP_005249550  XP_005249551  XP_005249554
 XP_005249555  XP_011513303  XP_011513305  XP_011513306  XP_016867008
 XP_016867009  XP_016867010  XP_016867011
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name Coordinate Modification PsiMod
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 1840 1840 polySUMO2,3 [nucleoplasm]
sumoylated lysine A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
UCSC human
GeneCards
DOCK Blaster
PRO
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.909 O60934 NBN_HUMAN 26
0.9 P16104 H2AX_HUMAN 16
0.725 O76064 RNF8_HUMAN 11
0.597 Q92878 RAD50_HUMAN 8
0.597 P49959 MRE11_HUMAN 8
0.528 P38398 BRCA1_HUMAN 2
0.499 Q13315 ATM_HUMAN 2