polySUMO2,3-K1840-MDC1 [nucleoplasm]

Stable Identifier
R-HSA-4570473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Mediator of DNA damage checkpoint protein 1, MDC1_HUMAN
polySUMO2,3-K1840-MDC1 [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
22635276 Sumoylation of MDC1 is important for proper DNA damage response

Lou, Z, Yuan, J, Luo, K, Wang, L, Zhang, H

EMBO J. 2012
External Reference Information
External Reference
Gene Names
MDC1, KIAA0170, NFBD1
Chain
chain:1-2089
Other Identifiers
0006200402
11748150_a_at
11748405_a_at
11751800_a_at
11758138_s_at
17016966
17026706
17028857
17031635
17034090
17036357
17039133
17041700
203061_PM_s_at
203061_s_at
203062_PM_s_at
203062_s_at
2948565
2948566
2948567
2948568
2948569
2948570
2948571
2948572
2948574
2948575
2948577
2948578
2948579
2948580
2948581
2948582
2948583
2948584
2948586
32661_s_at
32662_at
8124813
8178404
9656
A_23_P19455
D79992_at
GE87930
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005925
GO:0006259
GO:0006281
GO:0006950
GO:0006974
GO:0007049
GO:0007165
GO:0008022
GO:0008150
GO:0016604
GO:0031573
GO:0034641
GO:0043226
GO:0043229
GO:0070975
HMNXSV003044036
Hs.277585.0.A1_3p_a_at
ILMN_1814122
PH_hs_0020142
TC06001507.hg
TC6_apd_hap1000077.hg
TC6_cox_hap2000141.hg
TC6_dbb_hap3000130.hg
TC6_mann_hap4000119.hg
TC6_mcf_hap5000120.hg
TC6_qbl_hap6000131.hg
TC6_ssto_hap7000121.hg
g7661965_3p_a_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 1840
Coordinate
1840
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Interactors (14)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O60934 NBN  3 0.968 33
 UniProt:P16104 H2AX  7 0.965 21
 UniProt:O76064 RNF8  1 0.725 11
 UniProt:Q92878 RAD50  1 0.671 9
 UniProt:P49959 MRE11  2 0.671 9
 UniProt:P38398 BRCA1  20 0.629 4
 UniProt:Q13315 ATM  5 0.604 3
 UniProt:O96028-1 NSD2      0.602 3
 UniProt:O96028 NSD2  2 0.591 3
 UniProt:Q12888 TP53BP1  3 0.548 4
 UniProt:Q14676 MDC1  6 0.536 2
 UniProt:O76064-1 RNF8      0.524 2
 UniProt:Q06609 RAD51  2 0.524 3
 UniProt:Q9BXW9 FANCD2  3 0.483 2
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