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polySUMO2,3-CETN2 [nucleoplasm]
Stable Identifier
R-HSA-4570486
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Centrin-2, CETN2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
polySUMO2,3-CETN2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41208 CETN2
Gene Names
CETN2, CALT, CEN2
Chain
initiator methionine:, chain:2-172
Reference Genes
BioGPS Gene:1069 CETN2
COSMIC (genes):CETN2 CETN2
CTD Gene:1069 CETN2
dbSNP Gene:1069 CETN2
ENSEMBL:ENSG00000147400 CETN2
ENSEMBL_homo_sapiens_GENE:ENSG00000147400.10 CETN2
ENSEMBL_homo_sapiens_GENE:ENSG00000292191.1 CETN2
HGNC:1867 CETN2
KEGG Gene (Homo sapiens):1069 CETN2
Monarch:1069 CETN2
NCBI Gene:1069 CETN2
OMIM:300006 CETN2
UCSC:P41208 CETN2
Reference Transcript
RefSeq:NM_004344.1 CETN2
Other Identifiers
1069
11731436_at
17115077
209194_PM_at
209194_at
38410_at
4026260
4026262
4026264
4026265
4026266
4026267
4026268
4026270
4026273
8175755
A_23_P73493
GE81384
GO:0000278
GO:0000910
GO:0005509
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0005929
GO:0006281
GO:0006289
GO:0006974
GO:0007010
GO:0007049
GO:0007099
GO:0007283
GO:0008017
GO:0008092
GO:0015031
GO:0022414
GO:0031683
GO:0032391
GO:0032465
GO:0032795
GO:0036064
GO:0043226
GO:0044615
GO:0045177
GO:0046872
GO:0051028
GO:0051301
GO:0070390
GO:0071942
GO:0097729
HMNXSV003030971
ILMN_1695645
PH_hs_0004737
PH_hs_0035479
TC0X001506.hg
X72964_at
g13529121_3p_at
Participates
as an output of
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
Other forms of this molecule
CETN2 [cytosol]
CETN2 [nucleoplasm]
Inferred To
Dmel\CG17493 [nucleoplasm]
(Drosophila melanogaster)
cetn2 [nucleoplasm]
(Xenopus tropicalis)
CETN1 [nucleoplasm]
(Gallus gallus)
Cetn2 [nucleoplasm]
(Rattus norvegicus)
CG15158 [nucleoplasm]
(Drosophila melanogaster)
Dmel\CG13526 [nucleoplasm]
(Drosophila melanogaster)
Homologues of polySUMO2,3-CETN2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of polySUMO2,3-CETN2 [nucleoplasm]
(Drosophila melanogaster)
Homologues of polySUMO2,3-CETN2 [nucleoplasm]
(Plasmodium falciparum)
polySUMO2,3-CETN2 [nucleoplasm]
(Bos taurus)
polySUMO2,3-CETN2 [nucleoplasm]
(Dictyostelium discoideum)
polySUMO2,3-CETN2 [nucleoplasm]
(Mus musculus)
polySUMO2,3-CETN2 [nucleoplasm]
(Plasmodium falciparum)
polySUMO2,3-CETN2 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at unknown position
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_004335.1
OpenTargets
ENSG00000147400
HPA
ENSG00000147400-CETN2
GeneCards
P41208
Ensembl
ENSP00000359300
,
ENST00000370277
,
ENSG00000147400
PRO
P41208
Pharos - Targets
P41208
HMDB Protein
HMDBP07583
PDB
8EBS
,
2OBH
,
2A4J
,
8J07
,
1ZMZ
,
8EBW
,
2GGM
,
2K2I
,
1M39
,
8EBT
,
8EBX
,
8EBV
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NA72 POC5
0.915
14
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.901
14
UniProt:A8K8P3 SFI1
1
SFI1 [cytosol]
(R-HSA-380265)
0.737
5
UniProt:Q2NKQ1-4 SGSM1
0.718
6
UniProt:Q9H0E7 USP44
1
USP44 [nucleoplasm]
(R-HSA-5696942)
0.688
3
UniProt:P54727 RAD23B
2
RAD23B [nucleoplasm]
(R-HSA-62590)
RAD23B [cytosol]
(R-HSA-8850589)
0.671
6
UniProt:Q8NA72-3 POC5
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
13
UniProt:O14874 BCKDK
5
BCKDK [mitochondrial matrix]
(R-HSA-5693129)
R224P BCKDK [mitochondrial matrix]
(R-HSA-9912466)
R174Gfs1* BCKDK [mitochondrial matrix]
(R-HSA-9912469)
L389P BCKDK [mitochondrial matrix]
(R-HSA-9912461)
R156* BCKDK [mitochondrial matrix]
(R-HSA-9912465)
0.643
3
UniProt:O43303 CCP110
2
CCP110 [cytosol]
(R-HSA-380261)
PolyUb-CCP110 [cytosol]
(R-HSA-6783044)
0.641
5
UniProt:Q16513 PKN2
2
p-T816-PKN2 [cytosol]
(R-HSA-5623652)
PKN2 [cytosol]
(R-HSA-5623612)
0.604
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:Q8IW19 APLF
0.527
2
UniProt:Q5VW00 DC122
0.527
2
UniProt:Q9BQ69 MACD1
0.527
2
UniProt:Q70CQ1 USP49
1
USP49 [nucleoplasm]
(R-HSA-5696973)
0.527
2
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
3
UniProt:Q2NKQ1 SGSM1
0.527
4
UniProt:Q12798 CETN1
7
PolyUb-Misfolded CETN1 [late endosome lumen]
(R-HSA-9659982)
CETN1 [cilium]
(R-HSA-9639700)
Misfolded CETN1 [cilium]
(R-HSA-9639714)
Misfolded CETN1 [cytosol]
(R-HSA-9640113)
Ub-Misfolded CETN1 [cytosol]
(R-HSA-9641110)
PolyUb-Misfolded CETN1 [cytosol]
(R-HSA-9641126)
PolyUb-Misfolded CETN1 [lysosomal lumen]
(R-HSA-9659990)
0.527
4
UniProt:Q6ZNE5 ATG14
3
ATG14 [phagophore assembly site membrane]
(R-HSA-5682389)
ATG14 [endoplasmic reticulum membrane]
(R-HSA-5679263)
ATG14 [cytosol]
(R-HSA-5668893)
0.527
2
UniProt:P16104 H2AFX
7
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
0.527
3
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