CBX4 (Pc2) SUMOylates HNRNPK with SUMO2

Stable Identifier
R-HSA-4570499
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CBX4 (Pc2) SUMOylates HNRNPK at lysine-422 with SUMO2 (Li et al. 2004, Lee et al. 2012, Pelisch et al. 2012, Hendriks et al. 2014, Impens et al. 2014, Tammsalu et al. 2014). (Two molecules of SUMO2 are shown in the reaction in order to represent the oligomeric chains of SUMO2 that are attached to a target protein.) PIAS3 also SUMOylates HNRNPK predominantly with SUMO1 (Lee et al. 2012). HNRNPK is SUMOylated in response to DNA damage and SUMOylation is regulated by HIPK2 and CBX4. SUMOylation of HNRNPK is required for coactivation of TP53 (p53) activated transcription. SUMOylation increases the stability of HNRNPK, the nonSUMOylated form of which is normally ubiquinated by HDM2 (Lee et al. 2012).

Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
22825850 DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation

Pelisch, F, Pozzi, B, Risso, G, Muñoz, MJ, Srebrow, A

J. Biol. Chem. 2012
15161980 Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis

Li, T, Evdokimov, E, Shen, RF, Chao, CC, Tekle, E, Wang, T, Stadtman, ER, Yang, DC, Chock, PB

Proc. Natl. Acad. Sci. U.S.A. 2004
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

Lee, SW, Lee, MH, Park, JH, Kang, SH, Yoo, HM, Ka, SH, Oh, YM, Jeon, YJ, Chung, CH

EMBO J. 2012
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created