Reactome | polySUMO2-K422-HNRNPK [nucleoplasm]

polySUMO2-K422-HNRNPK [nucleoplasm]

Stable Identifier

R-HSA-4570532

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterogeneous nuclear ribonucleoprotein K, HNRPK_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014

External Reference Information

External Reference

UniProt:P61978 HNRNPK

Gene Names

HNRNPK, HNRPK

Chain

chain:1-463

Reference Genes

BioGPS Gene:3190 HNRNPK

COSMIC (genes):HNRNPK HNRNPK

CTD Gene:3190 HNRNPK

dbSNP Gene:3190 HNRNPK

ENSEMBL:ENSG00000165119 HNRNPK

HGNC:5044 HNRNPK

KEGG Gene (Homo sapiens):3190 HNRNPK

Monarch:3190 HNRNPK

NCBI Gene:3190 HNRNPK

OMIM:600712 HNRNPK

UCSC:P61978 HNRNPK

Reference Transcript

Other Identifiers

0003610551

11726680_s_at

11726681_x_at

11739211_x_at

11742796_x_at

11749210_x_at

16651691

16651693

17095318

18670433

18670435

18670437

18670441

18670442

18670443

18670444

18670446

18670447

18670448

18670449

18670450

200097_PM_s_at

200097_s_at

200775_PM_s_at

200775_s_at

240762_PM_at

240762_at

2578077

2578086

2578092

2632704

2632706

2632707

2632709

2874166

2874167

2874170

3190

3212293

3212295

3212296

3212297

3212298

3212299

3212300

3212301

3212302

3212306

3212308

3212310

3212312

3212313

3212314

3212315

3212316

3212319

3212321

3212324

3212330

3212331

3212332

3212334

3212335

3212341

3212342

39415_at

7893218

7893662

7894402

7894433

7894535

7894540

7894638

7894642

7895055

7895057

7895082

7895122

7895227

7895272

7895312

7895778

7895944

7896283

7896345

7896385

7896616

8162047

91973_at

A_24_P380919

A_24_P389517

GE81124

GE905840

GO:0000398

GO:0000785

GO:0002102

GO:0003674

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005694

GO:0005737

GO:0005856

GO:0005925

GO:0006357

GO:0006396

GO:0006397

GO:0006810

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0008380

GO:0009058

GO:0010468

GO:0010494

GO:0010988

GO:0016020

GO:0016192

GO:0019904

GO:0030054

GO:0032991

GO:0034641

GO:0042802

GO:0042995

GO:0043066

GO:0043226

GO:0045296

GO:0045892

GO:0045944

GO:0048024

GO:0048025

GO:0048260

GO:0070062

GO:0071013

GO:1902165

GO:1905599

GO:1990904

HMNXSV003040386

Hs.129548.1.A1_3p_a_at

Hs.170719.0.A1_3p_at

ILMN_1712357

ILMN_2378048

ILMN_3179371

ILMN_3260017

PH_hs_0023670

TC09001284.hg

X72727_at

g12653174_3p_a_at

Participates

as an output of

CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)

Other forms of this molecule

HNRNPK [nucleoplasm]

Inferred To

HnRNP-K [nucleoplasm] (Drosophila melanogaster)

hnrpkl [nucleoplasm] (Danio rerio)

Homologues of polySUMO2-K422-HNRNPK [nucleoplasm] (Gallus gallus)

hnrnpk [nucleoplasm] (Xenopus tropicalis)

HNRNPKL [nucleoplasm] (Gallus gallus)

Hnrnpk [nucleoplasm] (Mus musculus)

Hnrnpk [nucleoplasm] (Rattus norvegicus)

HNRNPK [nucleoplasm] (Bos taurus)

HNRNPK [nucleoplasm] (Gallus gallus)

Modified Residues

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 422

Coordinate

422

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_005252017.1, NP_112553.1, XP_005252020.1, XP_005252022.1, NP_002131.2, NP_001305115.1, NP_112552.1, XP_016870157.1, NP_001305116.1, NP_001305117.1

OpenTargets

ENSG00000165119

GeneCards

P61978

HPA

ENSG00000165119-HNRNPK

Ensembl

ENST00000360384, ENSP00000365458, ENST00000351839, ENSP00000353552, ENSP00000317788, ENST00000376281, ENSP00000365439, ENST00000376263, ENSG00000165119

PRO

P61978

Pharos - Targets

P61978

Orphanet

23740

PDB

1KHM, 1ZZJ, 1ZZI, 1ZZK, 1J5K

Interactors (65)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.848	10
UniProt:Q96PU8 QKI	2	QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466) QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546)	0.821	7
UniProt:Q14011 CIRBP			0.8	9
UniProt:P38159 RBMX	2	RBMX [nucleoplasm] (R-HSA-71939) RBMX [cytosol] (R-HSA-9715135)	0.8	11
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.747	4
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.668	3
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.668	3
UniProt:Q8WVV9 HNRLL			0.666	9
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.666	4
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.666	6
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.666	4
UniProt:Q5I0X4 CF226			0.666	7
UniProt:Q66K41 Z385C			0.666	7
UniProt:P79522 PRR3			0.666	7
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.666	4
UniProt:P43243 MATR3			0.666	4
UniProt:Q15415 RBY1F			0.666	4
UniProt:Q96MU7 YTDC1			0.666	4
UniProt:P29597 TYK2	5	p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.666	4
UniProt:P29846-PRO_0000037666			0.639	9
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.602	3
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y416-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.593	6
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.589	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.589	2
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.556	3
UniProt:Q5D0E6 DALD3			0.556	3
UniProt:P98179 RBM3			0.556	6
IntAct:EBI-16428938 CCSB ISOFORM ID			0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q6IPE9 Q6IPE9			0.556	6
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	6
UniProt:P29474 NOS3	7	2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) NOS3 [cytosol] (R-HSA-202114)	0.556	3
UniProt:Q96D16 Q96D16			0.556	6
UniProt:Q13148 TADBP			0.556	3
UniProt:Q9Y272 RASD1			0.556	6
UniProt:A0A0S2Z5X4 A0A0S2Z5X4			0.556	3
UniProt:P0DJD3 RBY1A			0.556	3
UniProt:Q9Y5E9 PCDBE			0.556	6
UniProt:P09172 DBH	1	DBH(40-617) [secretory granule lumen] (R-HSA-209790)	0.556	3
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:Q8N9J2 Q8N9J2			0.556	6
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P55064 AQP5	1	AQP5 [plasma membrane] (R-HSA-431738)	0.556	3
UniProt:Q9UQ90 SPG7	1	SPG7 [mitochondrial inner membrane] (R-HSA-8953712)	0.556	6
UniProt:G3V1X1 G3V1X1			0.556	3
IntAct:EBI-10171584 80125			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.556	3
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.556	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9Y580 RBM7			0.553	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.553	2
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.553	2
UniProt:Q8V1E7 Q8V1E7			0.543	5
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.537	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) AURKA [nucleoplasm] (R-HSA-4655443) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.524	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:P07550 ADRB2	5	pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) ADRB2 [endosome membrane] (R-HSA-6783036) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	2
UniProt:O43809 NUDT21	1	NUDT21 [nucleoplasm] (R-HSA-72010)	0.462	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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