Reactome | SUMO1-K250-HNRNPC [nucleoplasm]

SUMO1-K250-HNRNPC [nucleoplasm]

Stable Identifier

R-HSA-4570543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterogeneous nuclear ribonucleoproteins C1/C2, HNRPC_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07910 HNRNPC

Gene Names

HNRNPC, HNRPC

Chain

initiator methionine:, chain:2-306

Reference Genes

BioGPS Gene:3183 HNRNPC

COSMIC (genes):HNRNPC HNRNPC

CTD Gene:3183 HNRNPC

dbSNP Gene:3183 HNRNPC

ENSEMBL:ENSG00000092199 HNRNPC

HGNC:5035 HNRNPC

KEGG:hsa:3183 HNRNPC

Monarch:3183 HNRNPC

NCBI Gene:3183 HNRNPC

OMIM:164020 HNRNPC

UCSC:P07910 HNRNPC

Reference Transcript

Participates

as an output of

RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)

Other forms of this molecule

HNRNPC [nucleoplasm]

HNRNPC [cytosol]

Inferred To

hnrnpc [nucleoplasm] (Xenopus tropicalis)

SUMO1-K250-HNRNPC [nucleoplasm] (Schizosaccharomyces pombe)

Hnrnpc [nucleoplasm] (Mus musculus)

Hnrnpc [nucleoplasm] (Rattus norvegicus)

HNRNPC [nucleoplasm] (Sus scrofa)

NAB3 [nucleoplasm] (Saccharomyces cerevisiae)

HNRPC [nucleoplasm] (Bos taurus)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 250

Coordinate

250

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

OpenTargets

ENSG00000092199

ENSEMBL

ENSG00000092199, ENSP00000442816, ENSP00000451291, ENST00000556628, ENST00000430246, ENST00000557201, ENSP00000451176, ENSP00000451652, ENSP00000404848, ENST00000556897, ENSP00000452276, ENSP00000450544, ENST00000555883, ENST00000554969, ENST00000553300, ENSP00000450629, ENST00000554455, ENST00000420743, ENSP00000450725

GeneCards

HNRNPC

HPA

ENSG00000092199-HNRNPC

PRO

P07910

Pharos - Targets

P07910

GlyGen

P07910

PDB

1WF2, 2MZ1, 3LN4, 1TXP, 2MXY

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.863	8
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.845	7
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.834	8
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.792	5
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.749	5
UniProt:Q96IZ5 RBM41			0.742	5
UniProt:Q9UKM9 RALY			0.742	5
UniProt:Q86SE5 RALYL			0.742	7
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.731	4
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.718	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.718	6
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.706	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	18
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	7
UniProt:O60812 HNRC1			0.666	6
UniProt:B2RXH8 HNRC2			0.666	4
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.666	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.65	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.643	5
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.64	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.615	6
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.615	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.615	3
UniProt:Q14151 SAFB2			0.615	3
UniProt:Q96SI9 STRBP			0.615	3
UniProt:Q96KR1 ZFR			0.615	3
UniProt:Q53F19 NCBP3			0.615	4
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.615	3
UniProt:Q9BZJ0 CRNKL1	1	CRNKL1 [nucleoplasm] (R-HSA-8867899)	0.615	3
UniProt:Q8IX01 SUGP2			0.615	3
UniProt:O60506 HNRPQ			0.615	3
UniProt:Q8IUH3 RBM45			0.597	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.597	4
UniProt:Q96QD9 FYTTD1	1	FYTTD1 [nucleoplasm] (R-HSA-8852176)	0.564	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:Q9NQR1 KMT5A	1	SETD8 [nucleoplasm] (R-HSA-417142)	0.564	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.564	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q86SE5-3 RALYL			0.556	3
UniProt:Q13148 TADBP			0.556	3
UniProt:O15131 KPNA5	2	KPNA5 [nucleoplasm] (R-HSA-1176068) KPNA5 [cytosol] (R-HSA-1176062)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q68DK2-5 ZFYVE26			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q14103 HNRNPD	1	HNRNPD [nucleoplasm] (R-HSA-71935)	0.547	3
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.536	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.536	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.536	3
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.536	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.527	3
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	3
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P79522 PRR3			0.527	3
UniProt:Q6ZN17 LN28B			0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.527	2
UniProt:Q7Z6E9 RBBP6	1	RBBP6 [cytosol] (R-HSA-8850895)	0.527	3
UniProt:Q9NX05 F120C			0.527	2
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:P49761 CLK3			0.527	2
UniProt:Q8WUD4 CCDC12	1	CCDC12 [nucleoplasm] (R-HSA-9769561)	0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.525	2
UniProt:Q92879 CELF1			0.519	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q9NYF8 BCLF1			0.483	2
UniProt:Q8WXF1 PSPC1			0.483	2
UniProt:O14979 HNRNPDL	1	HNRNPDL [cytosol] (R-HSA-8950323)	0.483	2
UniProt:Q13151 HNRNPA0	1	HNRNPA0 [nucleoplasm] (R-HSA-71925)	0.483	2
UniProt:Q1KMD3 HNRL2			0.483	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q8NEY8 PPHLN1	1	PPHLN1 [nucleoplasm] (R-HSA-9844032)	0.483	2
UniProt:Q9BQ04 RBM4B			0.483	2
UniProt:Q13595 TRA2A			0.483	2
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.483	2
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.483	2
UniProt:Q9NW64 RBM22	1	RBM22 [nucleoplasm] (R-HSA-5215975)	0.483	2
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.483	2
UniProt:O15226 NKRF			0.483	2
UniProt:O15504 NUP42	1	NUPL2 [cytosol] (R-HSA-157697)	0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.483	2
UniProt:Q15003 NCAPH	3	p-T-NCAPH [cytosol] (R-HSA-2517885) p-S570-NCAPH [cytosol] (R-HSA-2529017) NCAPH [cytosol] (R-HSA-1638139)	0.483	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.483	2
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.483	2
UniProt:Q96DF8 ESS2			0.483	2
UniProt:Q6PJT7 ZC3HE			0.483	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.483	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.483	2
UniProt:O95758 PTBP3			0.483	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.483	6
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.483	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.483	2

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