Reactome | SUMO1-K250-HNRNPC [nucleoplasm]

SUMO1-K250-HNRNPC [nucleoplasm]

Stable Identifier

R-HSA-4570543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Heterogeneous nuclear ribonucleoproteins C1/C2, HNRPC_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07910 HNRNPC

Gene Names

HNRNPC, HNRPC

Chain

initiator methionine:1, chain:2-306

Reference Genes

BioGPS Gene:3183 HNRNPC

COSMIC (genes):HNRNPC HNRNPC

CTD Gene:3183 HNRNPC

dbSNP Gene:3183 HNRNPC

ENSEMBL:ENSG00000092199 HNRNPC

HGNC:5035 HNRNPC

KEGG Gene (Homo sapiens):3183 HNRNPC

Monarch:3183 HNRNPC

NCBI Gene:3183 HNRNPC

OMIM:164020 HNRNPC

UCSC:P07910 HNRNPC

Reference Transcript

Other Identifiers

0002480044

11732246_a_at

11732247_s_at

11756337_x_at

11758144_x_at

1568941_3p_a_at

1568941_PM_a_at

1568941_a_at

16653739

16653741

16653743

16653745

16653747

18671138

18671144

18671145

18671146

18671147

18671148

18671149

200014_PM_s_at

200014_s_at

200751_PM_s_at

200751_s_at

212626_PM_x_at

212626_x_at

214737_3p_x_at

214737_PM_x_at

214737_x_at

227110_PM_at

227110_at

2520052

2520055

2520056

2520057

3183

32408_s_at

3343617

33666_at

3384883

3555883

3555884

3555885

3555886

3555887

3555888

3555889

3555891

3555893

3555896

3555897

3555898

3555903

3555905

3555906

3555907

3555908

3555909

3555922

3555923

3555924

3555925

3555926

3555927

3555928

3555932

3556310

3556312

3556314

3556316

3556318

3556320

3556322

3648218

723_s_at

7892621

7892865

7892979

7893081

7893196

7893325

7893460

7894042

7894045

7894107

7894110

7894294

7894404

7894439

7894595

7894914

7894953

7895062

7895404

7895571

7895574

7896007

7896256

7896423

7977657

8047059

A_23_P163006

A_32_P142028

A_33_P3294017

GE61328

GO:0000398

GO:0000785

GO:0001649

GO:0003674

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005681

GO:0005694

GO:0005697

GO:0005737

GO:0005829

GO:0005856

GO:0006259

GO:0006338

GO:0006397

GO:0008150

GO:0008266

GO:0008380

GO:0009056

GO:0009058

GO:0015629

GO:0016020

GO:0030154

GO:0031492

GO:0032211

GO:0032991

GO:0034641

GO:0034655

GO:0042802

GO:0043226

GO:0051276

GO:0070034

GO:0070062

GO:0070935

GO:0071013

GO:1990247

HMNXSV003005460

Hs.182447.0.A1_3p_a_at

Hs.182447.0.A1_3p_x_at

Hs.182447.1.A1_3p_x_at

Hs.182447.2.A1_3p_at

Hs.182447.3.A1_3p_a_at

Hs2.250158.1.S1_3p_at

Hs2.250158.1.S1_3p_s_at

ILMN_1799634

ILMN_2334587

M16342_at

PH_hs_0030525

TC14000915.hg

g4758543_3p_a_at

Participates

as an output of

RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)

Other forms of this molecule

HNRNPC [cytosol]

HNRNPC [nucleoplasm]

Inferred To

SUMO1-K250-HNRNPC [nucleoplasm] (Danio rerio)

SUMO1-K250-HNRNPC [nucleoplasm] (Schizosaccharomyces pombe)

Hnrnpc [nucleoplasm] (Mus musculus)

Hnrnpc [nucleoplasm] (Rattus norvegicus)

NAB3 [nucleoplasm] (Saccharomyces cerevisiae)

HNRPC [nucleoplasm] (Bos taurus)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 250

Coordinate

250

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_004491.2, XP_011535010.1, XP_011535012.1, XP_016876742.1, NP_001070910.1, XP_016876741.1, XP_011535014.1, NP_001070911.1, NP_112604.2, XP_011535011.1, XP_006720188.1, XP_011535013.1

OpenTargets

ENSG00000092199

HPA

ENSG00000092199-HNRNPC

GeneCards

P07910

Ensembl

ENSP00000404848, ENSG00000092199, ENSP00000451291, ENSP00000450544, ENST00000556897, ENSP00000451652, ENST00000556628, ENSP00000450629, ENSP00000452276, ENSP00000451176, ENSP00000450725, ENSP00000442816, ENST00000430246, ENST00000554455, ENST00000555883, ENST00000554969, ENST00000553300, ENST00000557201, ENST00000420743

PRO

P07910

Pharos - Targets

P07910

PDB

2MZ1, 2MXY, 3LN4, 1TXP, 1WF2

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.863	8
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.816	9
UniProt:Q86SE5 RALYL			0.742	7
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.742	5
UniProt:Q96IZ5 RBM41			0.742	5
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.718	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	7
UniProt:P09651 HNRNPA1	1	HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.669	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.666	4
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.589	3
UniProt:Q9UKM9 RALY			0.573	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.564	2
UniProt:Q9NQR1 KMT5A	1	SETD8 [nucleoplasm] (R-HSA-417142)	0.564	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:O60812 HNRC1			0.556	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q68DK2-5 ZFYVE26			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
IntAct:EBI-22370853 CCSB ORF ID			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:B2RXH8 HNRC2			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q86SE5-3 RALYL			0.556	3
UniProt:Q13148 TADBP			0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	6
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.525	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3

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