Reactome: A Curated Pathway Database

SUMOylation of MDC1 with SUMO2,3

Stable Identifier
R-HSA-4570553
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MDC1 is SUMOylated at lysine-1840 with SUMO2,3 (Luo et al. 2012, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation is required for degradation of MDC1. SUMOylation of MDC1 is required for recruitment of RNF4 (Yin et al. 2012), which is believed to ubiquitinylate MDC1, resulting in degradation of MDC1.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events