Reactome: A Curated Pathway Database

SUMOylation of MDC1 with SUMO1

Stable Identifier
R-HSA-4570554
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MDC1 is SUMOylated at lysine-1840 with SUMO1. SUMOyation of MDC1 is required for its degradation, which is thought to be directed by ubiquitinylation by RNF4 (Luo et al. 2012).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm] SUMO1:C93-UBE2I [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events