SUMOylation of MDC1 with SUMO1

Stable Identifier
R-HSA-4570554
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MDC1 is SUMOylated at lysine-1840 with SUMO1. SUMOyation of MDC1 is required for its degradation, which is thought to be directed by ubiquitinylation by RNF4 (Luo et al. 2012).

Literature References
PubMed ID Title Journal Year
22635276 Sumoylation of MDC1 is important for proper DNA damage response EMBO J. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed