SMURF1/2 are recruited to the DVL2:PARD6A complex

Stable Identifier
R-HSA-4608854
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The E3 ubiquitin ligases SMURF1/2 are recruited to the DVL:PARD6A complex after WNT5A stimulation. Recruitment depends on DVL2 phosphorylation and is mediated by the DEP domain of DVL2 that is important for PCP signaling (Narimatsu et al, 2009; Boutros et al, 1998). Smurf1 and 2 mutant mice show defects in convergent extension and neural tube closure, as well as misorientation of sensory hairs in the inner ear, phenotypes consistent with a role for SMURFs in the PCP pathway (Narimatsu et al, 2009).

Literature References
PubMed ID Title Journal Year
9674432 Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling

Boutros, M, Paricio, N, Strutt, DI, Mlodzik, M

Cell 1998
19379695 Regulation of planar cell polarity by Smurf ubiquitin ligases

Narimatsu, M, Bose, R, Pye, M, Zhang, L, Miller, B, Ching, P, Sakuma, R, Luga, V, Roncari, L, Attisano, L, Wrana, JL

Cell 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created