SUMOylation of DNA replication proteins

Stable Identifier
R-HSA-4615885
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-strand breaks and inappropriate recombination (reviewed in Watts 2006, Watts 2007, Dieckman et al. 2012, Gazy and Kupiec 2012). SUMOylation of Aurora-A, Aurora-B, and Borealin is necessary for proper chromosome segregation. SUMOylation of topoisomerases is observed in response to damage caused by inhibitors of topoisomerases.

Literature References
PubMed ID Title Journal Year
22918591 PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA

Dieckman, LM, Freudenthal, BD, Washington, MT

Subcell. Biochem. 2012
22732495 The importance of being modified: PCNA modification and DNA damage response

Gazy, I, Kupiec, M

Cell Cycle 2012
22812528 SUMOylation in control of accurate chromosome segregation during mitosis

Wan, J, Subramonian, D, Zhang, XD

Curr. Protein Pept. Sci. 2012
17031663 The role of SUMO in chromosome segregation

Watts, FZ

Chromosoma 2007
16368276 Sumoylation of PCNA: Wrestling with recombination at stalled replication forks

Watts, FZ

DNA Repair (Amst.) 2006
Participants
Participant Of
Orthologous Events
Authored
Reviewed