SUMOylation of HDAC1 with SUMO1

Stable Identifier
R-HSA-4615889
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HDAC1 is SUMOylated at lysine-444 and lysine-476 with SUMO1 (Kirsh et al. 2002, David et al. 2002, Cheng et al. 2004, Citro et al. 2013). SUMOylation with SUMO1 enhances transcription repression by HDAC1 and promotes degradation of HDAC1 (Citro et al. 2013). HDAC1 can also be SUMOylated with SUMO2, which enhances stability of HDAC1 (Citro et al. 2013).

Literature References
PubMed ID Title Journal Year
15199155 SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1

Cheng, J, Wang, D, Wang, Z, Yeh, ET

Mol. Cell. Biol. 2004
24068740 A role for paralog-specific sumoylation in histone deacetylase 1 stability

Citro, S, Jaffray, E, Hay, RT, Seiser, C, Chiocca, S

J Mol Cell Biol 2013
11960997 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities

David, G, Neptune, MA, DePinho, RA

J. Biol. Chem. 2002
12032081 The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

Kirsh, O, Seeler, JS, Pichler, A, Gast, A, Müller, S, Miska, E, Mathieu, M, Harel-Bellan, A, Kouzarides, T, Melchior, F, Dejean, A

EMBO J. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created