SUMO1-K462-HDAC2 [nucleoplasm]

Stable Identifier
R-HSA-4615958
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone deacetylase 2, HDAC2_HUMAN
Icon
SUMO1-K462-HDAC2 [nucleoplasm] icon
SUMO1-K462-HDAC2 [nucleoplasm] icon
Locations in the PathwayBrowser
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External Reference Information
External Reference
UniProt:Q92769 HDAC2
Gene Names
HDAC2
Chain
chain:1-488
Reference Genes
BioGPS Gene:3066 HDAC2
COSMIC (genes):HDAC2 HDAC2
CTD Gene:3066 HDAC2
dbSNP Gene:3066 HDAC2
ENSEMBL:ENSG00000196591 HDAC2
HGNC:4853 HDAC2
KEGG Gene (Homo sapiens):3066 HDAC2
Monarch:3066 HDAC2
NCBI Gene:3066 HDAC2
OMIM:605164 HDAC2
UCSC:Q92769 HDAC2
Reference Transcript
Other Identifiers
0003870377
0106510204
11727379_at
11754781_a_at
201833_at
242141_at
2970534
2970535
2970536
2970537
2970538
2970539
2970540
2970541
2970542
2970543
2970544
2970545
2970546
2970548
2970549
2970550
2970551
2970552
2970553
2970556
2970557
2970562
2970566
2970567
2970571
2970573
2970575
2970577
2970578
2970579
2970580
2970581
2970582
2970583
3066
34368_at
8129045
A_23_P122304
A_33_P3309924
GE81034
GE860085
GO:0000003
GO:0000118
GO:0000122
GO:0000228
GO:0000785
GO:0000790
GO:0000978
GO:0001103
GO:0001975
GO:0003300
GO:0003674
GO:0003677
GO:0003682
GO:0003723
GO:0004407
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006325
GO:0006338
GO:0006344
GO:0006464
GO:0006950
GO:0007165
GO:0007596
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0009790
GO:0009913
GO:0010718
GO:0010870
GO:0010977
GO:0016358
GO:0016575
GO:0016580
GO:0016581
GO:0016787
GO:0016810
GO:0019213
GO:0019899
GO:0030154
GO:0031000
GO:0031072
GO:0031492
GO:0032041
GO:0032496
GO:0032732
GO:0032760
GO:0032922
GO:0032967
GO:0032991
GO:0033558
GO:0034605
GO:0034641
GO:0035094
GO:0035098
GO:0042220
GO:0042475
GO:0042493
GO:0042531
GO:0042733
GO:0042826
GO:0043044
GO:0043066
GO:0043226
GO:0043392
GO:0043433
GO:0043565
GO:0045347
GO:0045862
GO:0045892
GO:0045893
GO:0045944
GO:0048149
GO:0048511
GO:0048646
GO:0048714
GO:0048856
GO:0051059
GO:0051276
GO:0055093
GO:0060789
GO:0061000
GO:0061029
GO:0061198
GO:0070301
GO:0070822
GO:0070932
GO:0070933
GO:0071300
GO:0071560
GO:1901796
GO:1902437
GO:1903351
GO:1990841
GO:2000757
Hs.232662.0.A1_3p_at
Hs.232662.0.A1_3p_x_at
ILMN_1767747
ILMN_1915551
ILMN_3251283
PH_hs_0000406
TC06002035.hg
TC06003812.hg
U31814_at
g4557640_3p_at
Participant Of
hasComponent
Other forms of this molecule
HDAC2 [nucleoplasm]
Inferred To
hdaA [nucleoplasm] (Dictyostelium discoideum)
hda-1 [nucleoplasm] (Caenorhabditis elegans)
clr6 [nucleoplasm] (Schizosaccharomyces pombe)
Hdac2 [nucleoplasm] (Mus musculus)
Hdac2 [nucleoplasm] (Rattus norvegicus)
SUMO1-K462-HDAC2 [nucleoplasm] (Bos taurus)
SUMO1-K462-HDAC2 [nucleoplasm] (Plasmodium falciparum)
SUMO1-K462-HDAC2 [nucleoplasm] (Sus scrofa)
RPD3 [nucleoplasm] (Saccharomyces cerevisiae)
HDAC2 [nucleoplasm] (Canis familiaris)
hdac2 [nucleoplasm] (Xenopus tropicalis)
Modified Residues
Name
Inter-chain Crosslink via sumoylated lysine at 462 and 97
Coordinate
462
Modification
glycyl group
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
IntEnz
HPA
GeneCards
Ensembl
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (55)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13547 HDAC1  2 0.929 13
 UniProt:Q13330 MTA1  2 0.802 5
 UniProt:Q96ST3 SIN3A  2 0.793 5
 UniProt:O94776 MTA2  1 0.788 7
 UniProt:Q9NP66 HM20A      0.725 4
 UniProt:Q9BTC8 MTA3  1 0.725 5
 UniProt:Q9HCU9 BRMS1  1 0.723 4
 UniProt:O95983 MBD3  1 0.69 4
 UniProt:Q8N108 MIER1      0.643 3
 UniProt:Q16576 RBBP7  1 0.643 3
 UniProt:Q9UKL0 RCOR1  1 0.643 3
 UniProt:O14519 CDKA1      0.643 3
 UniProt:Q6PJG2 MDEAS      0.643 3
 UniProt:Q8WXI9 GATAD2B  1 0.643 3
 UniProt:Q14839 CHD4  1 0.643 4
 UniProt:O60341 KDM1A  1 0.643 6
 UniProt:Q9UBB5 MBD2  1 0.643 3
 UniProt:Q9C0K0 BC11B      0.602 3
 UniProt:Q96KQ7 EHMT2  1 0.597 7
 UniProt:Q9HD15 SRA1      0.589 2
 UniProt:P01106 MYC  2 0.564 2
 UniProt:Q2HR82 KBZIP      0.537 7
 UniProt:Q8N5A5 ZGPAT      0.532 3
 UniProt:Q96BD5 PHF21A  1 0.527 2
 UniProt:Q92766 RREB1      0.527 2
 UniProt:P61964 WDR5  1 0.527 2
 UniProt:Q8N344 MIER2      0.527 2
 UniProt:O75182 SIN3B  1 0.527 2
 UniProt:Q86YP4 GATAD2A  1 0.527 2
 UniProt:Q8IZ40 RCOR2      0.527 2
 UniProt:Q9UKG1 APPL1  1 0.527 2
 UniProt:Q9UBW7 ZMYM2  2 0.527 2
 UniProt:Q14687 GSE1      0.527 2
 UniProt:Q9H147 TDIF1      0.527 3
 UniProt:Q9BYE7 PCGF6  1 0.527 2
 UniProt:O75446 SAP30  1 0.527 2
 UniProt:Q9P2K3 RCOR3      0.527 2
 UniProt:Q9P0W2 HMG20B  1 0.527 2
 UniProt:Q12873 CHD3  2 0.527 3
 UniProt:Q9Y232 CDYL      0.527 3
 UniProt:Q09028 RBBP4  1 0.527 2
 UniProt:O95863 SNAI1  1 0.525 2
 UniProt:Q9UER7 DAXX  2 0.524 2
 UniProt:O43463 SUV39H1  1 0.524 3
 UniProt:Q9UIS9 MBD1  2 0.524 2
 UniProt:P53350 PLK1  4 0.508 2
 UniProt:Q17R98 ZN827      0.499 2
 UniProt:P48382 RFX5      0.499 4
 UniProt:P51610 HCFC1  2 0.499 2
 UniProt:O60315 ZEB2      0.462 4
 UniProt:P23771 GATA3  2 0.462 4
 UniProt:Q9BSJ6 PIMRE      0.462 2
 UniProt:A2A935  1 0.462 2
 UniProt:P17542 TAL1  1 0.462 3
 UniProt:P03372 ESR1  8 0.462 2
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