Reactome | SUMO1-K462-HDAC2 [nucleoplasm]

SUMO1-K462-HDAC2 [nucleoplasm]

Stable Identifier

R-HSA-4615958

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 2, HDAC2_HUMAN

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of chromatin organization proteins (Homo sapiens)
        
        SUMOylation of HDAC2 with SUMO1 (Homo sapiens)
        
        SUMO1:HDAC2 [nucleoplasm] (Homo sapiens)
        
        SUMO1-K462-HDAC2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92769 HDAC2

Gene Names

HDAC2

Chain

chain:1-488

Reference Genes

BioGPS Gene:3066 HDAC2

COSMIC (genes):HDAC2 HDAC2

CTD Gene:3066 HDAC2

dbSNP Gene:3066 HDAC2

ENSEMBL:ENSG00000196591 HDAC2

HGNC:4853 HDAC2

KEGG Gene (Homo sapiens):3066 HDAC2

Monarch:3066 HDAC2

NCBI Gene:3066 HDAC2

OMIM:605164 HDAC2

UCSC:Q92769 HDAC2

Reference Transcript

Other Identifiers

0003870377

0106510204

11727

11727379_at

11754781_a_at

201833_at

242141_at

2970534

2970535

2970536

2970537

2970538

2970539

2970540

2970541

2970542

2970543

2970544

2970545

2970546

2970548

2970549

2970550

2970551

2970552

2970553

2970556

2970557

2970562

2970566

2970567

2970571

2970573

2970575

2970577

2970578

2970579

2970580

2970581

2970582

2970583

3066

34368_at

3MAX

4LXZ

4LY1

5054

5IWG

5IX0

6G3O

8129045

A_23_P122304

A_33_P3309924

AAC50814

AAH31055

AK092156

AK296856

AL590398

AL671967

BAG52487

BAG59420

BC031055

CAB005054

CCDS43493

CH471051

E5RFI6

E5RFP9

E5RG37

E5RGV4

E5RH52

E5RHE7

E5RJ04

E5RK19

EAW48252

EAW48253

EAW48254

EAW48255

ENSG00000196591

ENSP00000357621

ENSP00000430008

ENSP00000430432

ENST00000368632

ENST00000368632.6

ENST00000519065

ENST00000519065.5

ENST00000519108

ENST00000519108.5

EntrezGene:3066

EntrezGene:HDAC2

FO393415

g4557640_3p_at

GE81034

GE860085

GO:0000003

GO:0000118

GO:0000122

GO:0000228

GO:0000785

GO:0000790

GO:0000978

GO:0000980

GO:0001103

GO:0001975

GO:0003300

GO:0003674

GO:0003677

GO:0003682

GO:0003723

GO:0004407

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006344

GO:0006464

GO:0006950

GO:0007165

GO:0007596

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009790

GO:0009913

GO:0010718

GO:0010870

GO:0010977

GO:0016358

GO:0016575

GO:0016580

GO:0016581

GO:0016787

GO:0016810

GO:0019213

GO:0019899

GO:0030154

GO:0031000

GO:0031072

GO:0031492

GO:0032041

GO:0032496

GO:0032732

GO:0032760

GO:0032922

GO:0032967

GO:0032991

GO:0033558

GO:0034605

GO:0034641

GO:0035094

GO:0035098

GO:0042220

GO:0042475

GO:0042493

GO:0042531

GO:0042733

GO:0042826

GO:0043044

GO:0043066

GO:0043226

GO:0043392

GO:0043433

GO:0043565

GO:0045347

GO:0045862

GO:0045892

GO:0045893

GO:0045944

GO:0048149

GO:0048511

GO:0048646

GO:0048714

GO:0048856

GO:0051059

GO:0051276

GO:0055093

GO:0060789

GO:0061000

GO:0061029

GO:0061198

GO:0070301

GO:0070822

GO:0070932

GO:0070933

GO:0071300

GO:0071560

GO:1901796

GO:1902437

GO:1903351

GO:1990841

GO:2000757

H3BM24

HDAC2

HDAC2-201

HDAC2-205

HDAC2-206

HGNC:4853

HPA011727

Hs.232662.0.A1_3p_at

Hs.232662.0.A1_3p_x_at

ILMN_1767747

ILMN_1915551

ILMN_3251283

IPR000286

IPR003084

IPR023696

IPR023801

IPR037138

MIM:605164

NM_001527

NP_001518

NR_033441

NR_073443

PF00850

PH_hs_0000406

PR01270

PR01271

TC06002035.hg

TC06003812.hg

U31814

U31814_at

UPI000013F764

UPI000020E11B

XM_017010799

XP_016866288

Participant Of

hasComponent

SUMO1:HDAC2 [nucleoplasm]

Other forms of this molecule

HDAC2 [nucleoplasm]

Inferred To

SUMO1-K462-HDAC2 [nucleoplasm] (Bos taurus)

SUMO1-K462-HDAC2 [nucleoplasm] (Caenorhabditis elegans)

SUMO1-K462-HDAC2 [nucleoplasm] (Canis familiaris)

SUMO1-K462-HDAC2 [nucleoplasm] (Dictyostelium discoideum)

SUMO1-K462-HDAC2 [nucleoplasm] (Mus musculus)

SUMO1-K462-HDAC2 [nucleoplasm] (Plasmodium falciparum)

SUMO1-K462-HDAC2 [nucleoplasm] (Rattus norvegicus)

SUMO1-K462-HDAC2 [nucleoplasm] (Saccharomyces cerevisiae)

SUMO1-K462-HDAC2 [nucleoplasm] (Schizosaccharomyces pombe)

SUMO1-K462-HDAC2 [nucleoplasm] (Sus scrofa)

SUMO1-K462-HDAC2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at 462 and 97

Coordinate

462

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_011534090.1, NP_001518.3, XP_016866288.1

ZINC - World Drugs

HDAC2_HUMAN

OpenTargets

ENSG00000196591

ZINC - FDA approved

HDAC2_HUMAN

ZINC - Substances

HDAC2_HUMAN

ZINC - Biogenic

HDAC2_HUMAN

ZINC target

Q92769

PRO

Q92769

PDB

5IX0, 6G3O, 5IWG, 4LY1, 4LXZ, 3MAX

ZINC - Investigational

HDAC2_HUMAN

ZINC - Metabolites

HDAC2_HUMAN

IntEnz

3.5.1.98

GeneCards

Q92769

ZINC - Predictions - Purchasable

HDAC2_HUMAN

Orphanet

24589

HMDB Protein

HMDBP09107

Interactors (55)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.929	13
UniProt:Q13330 MTA1	2	SUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537) MTA1 [nucleoplasm] (R-HSA-3465550)	0.802	5
UniProt:Q96ST3 SIN3A	2	SUMO1-SIN3A [nucleoplasm] (R-HSA-4086071) SIN3A [nucleoplasm] (R-HSA-351657)	0.793	5
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.725	5
UniProt:Q9NP66 HM20A			0.725	4
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.725	5
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.723	4
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.69	4
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.643	4
UniProt:Q8N108 MIER1			0.643	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.643	6
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.643	3
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.643	3
UniProt:O14519 CDKA1			0.643	3
UniProt:Q6PJG2 EMSA1			0.643	3
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.643	3
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	3
UniProt:Q9C0K0 BC11B			0.602	3
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.597	7
UniProt:Q9HD15 SRA1			0.589	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:Q2HR82 KBZIP			0.537	7
UniProt:Q8N5A5 ZGPAT			0.532	3
UniProt:Q96BD5 PHF21A	1	PHF21A [nucleoplasm] (R-HSA-996754)	0.527	2
UniProt:Q92766 RREB1			0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:Q8N344 MIER2			0.527	2
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.527	2
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.527	2
UniProt:Q8IZ40 RCOR2			0.527	2
UniProt:Q9UBW7 ZMYM2	2	ZMYM2-p-2Y-FGFR1 fusion [cytosol] (R-HSA-1839016) ZMYM2-FGFR1 fusion [cytosol] (R-HSA-1604544)	0.527	2
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	2
UniProt:Q14687 GSE1			0.527	2
UniProt:Q9H147 TDIF1			0.527	3
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	2
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.527	2
UniProt:Q9P2K3 RCOR3			0.527	2
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.527	2
UniProt:Q9Y232 CDYL			0.527	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.527	2
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.527	3
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.525	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.524	3
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) SUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.524	2
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.524	2
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.508	2
UniProt:Q17R98 ZN827			0.499	2
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.499	2
UniProt:P48382 RFX5			0.499	4
UniProt:O60315 ZEB2			0.462	4
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4
UniProt:Q9BSJ6 PIMRE			0.462	2
UniProt:A2A935	1	PRDM16 [cytosol] (R-MMU-5634812)	0.462	2
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.462	3