Reactome | polySUMO2,3-K744-SATB1 [nucleoplasm]

polySUMO2,3-K744-SATB1 [nucleoplasm]

Stable Identifier

R-HSA-4615978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA-binding protein SATB1, SATB1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20351170	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1 Chen, Y, Song, J, Durrin, LK, Tan, JA	Mol. Cell. Biol.	2010
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
18408014	SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage Chen, Y, Sun, Y, Krontiris, TG, Song, J, Durrin, LK, Tan, JA	J. Biol. Chem.	2008

External Reference Information

External Reference

UniProt:Q01826 SATB1

Gene Names

SATB1

Chain

chain:1-763

Reference Genes

BioGPS Gene:6304 SATB1

COSMIC (genes):SATB1 SATB1

CTD Gene:6304 SATB1

dbSNP Gene:6304 SATB1

ENSEMBL:ENSG00000182568.17 SATB1

HGNC:10541 SATB1

KEGG Gene (Homo sapiens):6304 SATB1

Monarch:6304 SATB1

NCBI Gene:6304 SATB1

OMIM:602075 SATB1

UCSC:Q01826 SATB1

Reference Transcript

Other Identifiers

0002900021

11741058_a_at

11741059_s_at

11754725_x_at

16951409

203408_PM_s_at

203408_s_at

241365_PM_at

241365_at

2665197

2665198

2665200

2665201

2665202

2665203

2665205

2665207

2665225

2665227

2665231

2665233

2665241

2665242

2665243

2665252

2665256

2665257

2665258

2665259

2665260

2665261

2665267

35667_at

36899_at

46768_r_at

53365_f_at

6304

73870_at

8085716

87288_at

A_23_P259741

GE624984

GE78977

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0003677

GO:0003690

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0016363

GO:0016604

GO:0016605

GO:0043226

GO:0043565

HMNXSV003048348

Hs.33024.0.A1_3p_at

ILMN_1690646

ILMN_1882495

M97287_at

PH_hs_0002783

PH_hs_0040811

TC03003338.hg

U33920_at

g4506790_3p_a_at

g4759089_3p_at

Participates

as an output of

PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K744-SATB1 [nucleoplasm]

SATB1(255-763) [nucleoplasm]

SATB1(1-254) [nucleoplasm]

SATB1 [nucleoplasm]

Inferred To

Satb1 [nucleoplasm] (Rattus norvegicus)

dve [nucleoplasm] (Drosophila melanogaster)

SATB1 [nucleoplasm] (Bos taurus)

SATB1 [nucleoplasm] (Gallus gallus)

satb1 [nucleoplasm] (Xenopus tropicalis)

polySUMO2,3-K744-SATB1 [nucleoplasm] (Canis familiaris)

polySUMO2,3-K744-SATB1 [nucleoplasm] (Danio rerio)

polySUMO2,3-K744-SATB1 [nucleoplasm] (Mus musculus)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 744

Coordinate

744

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_011532291.1, NP_001309800.1, NP_001309802.1, NP_001124482.1, XP_011532290.1, NP_001309804.1, NP_001182399.1, NP_001309801.1, NP_002962.1, NP_001309803.1

OpenTargets

ENSG00000182568

HPA

ENSG00000182568-SATB1

GeneCards

Q01826

Ensembl

ENSP00000341024, ENSP00000399708, ENST00000417717, ENSP00000399518, ENSG00000182568, ENST00000338745, ENST00000454909

PRO

Q01826

Pharos - Targets

Q01826

Orphanet

28533

PDB

2O4A, 3NZL, 3TUO, 2L1P, 2MW8, 1YSE, 6LFF, 2O49

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.66	9
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P63279 UBE2I	8	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.553	2
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.508	2
UniProt:Q12952 FOXL1			0.483	2

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