Reactome | SUMO2,3-K744-SATB1 [nucleoplasm]

SUMO2,3-K744-SATB1 [nucleoplasm]

Stable Identifier

R-HSA-4615978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA-binding protein SATB1, SATB1_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
18408014	SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage Chen, Y, Sun, Y, Krontiris, TG, Song, J, Durrin, LK, Tan, JA	J. Biol. Chem.	2008
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
20351170	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1 Chen, Y, Song, J, Durrin, LK, Tan, JA	Mol. Cell. Biol.	2010

External Reference Information

External Reference

UniProt:Q01826 SATB1

Gene Names

SATB1

Chain

chain:1-763

Reference Genes

BioGPS Gene:6304 SATB1

COSMIC (genes):SATB1 SATB1

CTD Gene:6304 SATB1

dbSNP Gene:6304 SATB1

ENSEMBL:ENSG00000182568 SATB1

HGNC:10541 SATB1

KEGG Gene (Homo sapiens):6304 SATB1

Monarch:6304 SATB1

NCBI Gene:6304 SATB1

OMIM:602075 SATB1

UCSC:Q01826 SATB1

Reference Transcript

Other Identifiers

0002900021

11741058_a_at

11741059_s_at

11754725_x_at

16951409

203408_s_at

241365_at

2665197

2665198

2665200

2665201

2665202

2665203

2665205

2665207

2665225

2665227

2665231

2665233

2665241

2665242

2665243

2665252

2665256

2665257

2665258

2665259

2665260

2665261

2665267

35667_at

36899_at

46768_r_at

53365_f_at

6304

73870_at

8085716

87288_at

A_23_P259741

GE624984

GE78977

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0003674

GO:0003677

GO:0003690

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006357

GO:0008150

GO:0009058

GO:0016032

GO:0016363

GO:0016604

GO:0016605

GO:0034641

GO:0043226

GO:0043565

GO:0044403

GO:0051276

HMNXSV003048348

Hs.33024.0.A1_3p_at

ILMN_1690646

ILMN_1882495

M97287_at

PH_hs_0002783

PH_hs_0040811

TC03003338.hg

U33920_at

g4506790_3p_a_at

g4759089_3p_at

Participates

as an output of

PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

SUMO1-K744-SATB1 [nucleoplasm]

SATB1(255-763) [nucleoplasm]

SATB1(1-254) [nucleoplasm]

SATB1 [nucleoplasm]

Inferred To

Satb1 [nucleoplasm] (Mus musculus)

Satb1 [nucleoplasm] (Rattus norvegicus)

satb1b [nucleoplasm] (Danio rerio)

SUMO2,3-K744-SATB1 [nucleoplasm] (Gallus gallus)

SUMO2,3-K744-SATB1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 744

Coordinate

744

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_011532290.1, NP_001309804.1, NP_001309800.1, NP_001309802.1, NP_001182399.1, NP_001124482.1, XP_011532291.1, NP_001309801.1, NP_001309803.1, NP_002962.1

OpenTargets

ENSG00000182568

HPA

ENSG00000182568-SATB1

GeneCards

Q01826

Ensembl

ENST00000454909, ENSP00000399708, ENST00000338745, ENSG00000182568, ENST00000417717, ENSP00000399518, ENSP00000341024

PRO

Q01826

Pharos - Targets

Q01826

GlyGen

Q01826

Orphanet

28533

PDB

2L1P, 3NZL, 3TUO, 6LFF, 1YSE, 2MW8, 2O49, 2O4A

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45P [cytosol] (R-HSA-4791272) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619)	0.66	9
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P63279 UBE2I	8	SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481)	0.553	2
UniProt:P63165 SUMO1	20	K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305)	0.508	2

Cite Us!