Reactome | SUMOylation of HDAC2 with SUMO1

SUMOylation of HDAC2 with SUMO1

Stable Identifier

R-HSA-4616015

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HDAC2 is SUMOylated at lysine-462 with SUMO1 (Brandl et al. 2012). SUMOylation of HDAC2 blocks TP53-dependent (p53-dependent) expression of genes but is required for induction of NF-kB-dependent gene expression (Wagner et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
22493095	Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress Brandl, A, Wagner, T, Uhlig, KM, Knauer, SK, Stauber, RH, Melchior, F, Schneider, G, Heinzel, T, Krämer, OH	J Mol Cell Biol	2012
25704882	Sumoylation of HDAC2 promotes NF-κB-dependent gene expression Wagner, T, Kiweler, N, Wolff, K, Knauer, SK, Brandl, A, Hemmerich, P, Dannenberg, JH, Heinzel, T, Schneider, G, Krämer, OH	Oncotarget	2015